Anaplastic Large Cell Lymphoma (ALCL) rudzi rusingawanzwisisiki rweHodgkin's lymphoma (NHL) runobva kuT-cells. T-masero ndiwo rudzi rwemasiviri emuviri anodzivirira muviri kubva kune utachiona. Kune mhando mbiri dzeplastiki yakakura masero lymphoma, nyanzvi yemutambo, uye yemhando yekutanga.
- Rudzi rwemuitiro runobata lymph nodes nedzimwe nhengo.
- Rudzi rwakaoma runobata kunyanya ganda
Primary Systemic Type
Rudzi rwemagetsi rweAllig runoita vose vana nevakuru. Muvanhu vakuru, inenge isingawanzovi lymphoma, asi muvana, ALCL inobata chikamu chimwe muzvikamu gumi zvema-lymphomas ose. Vanhu vakawanda vane lymphoma iyi vanotanga kunyunyuta nezvemakondomu akawedzerwa , zvisinei kuti hazviwanzovhiringidza matumbo kana pfupa risina kubatanidza lymph nodes.
Kuongororwa kunogadzirwa ne biopsy kubva kuma-lymph nodes kana nhengo dzakagadzirirwa. Icho chinopisa chinoratidzira zvakanakira kuplastic muenzaniso weiyi lymphoma pasi pe microscope. Muongorori wezvirwere anowanzotarisa mhuka yebiopsy ine mhando dzakakosha dzemazuva ano dzinogona kutora molecule inonzi CD30 pamusoro pekenza masero muAlCL. Kuvapo kweiyo CD30 molecule kunoritsanangurira kune mamwe marudzi eNHL .
Chimwe chikwangwani chekuedzwa kweprotheni chaiyo, inonzi ALK protein, inoitwawo. Havasi vanhu vose vane ALCL vane mazano kune ALK.
Avo vane ALK protein fare zviri nani mushure mehutano kupfuura avo vasina. Vana vanowanzova neprotein yeAlk kupfuura vanhu vakuru.
Kamwe kuongororwa kweAlCL kunosimbiswa, mhando dzeongororo dzinoitwa kuti dziwane lymphoma .
Systemic ALCL inorapwa ne chemotherapy. Mishonga yekurapa inowanzova yakanaka, kunyanya kune avo vari ALK-positive.
Rituximab , anonochenal monoclonal, inoshandiswa mune dzimwe nzira dzakawanda dzeNHL haina kushandiswa muAlCL nokuti haishandisi T-cell lymphomas. Pane kudaro, Brentuximab vedotin (Adcetris) inotarisa CD30 molecule uye yakagamuchirwa neDDA muna 2011 kuti inorapwa neAlCL kune avo vane zvirwere zvakasara mushure mekurapa kana kuti avo vane chirwere chakadzoka mushure mekubudirira kwekurapa.
Tsika Yokutanga Yakakosha
Rudzi rweAlCL rwakakanganisika runonyanya kunyanya ganda. Iyo ndiyo yechipiri inonyanyosiyana yeutachiona isiri Hodgkin lymphoma inobata ganda - mushure mekucheka T-cell lymphoma (CTCL) . ALCL yeganda achiri chiitiko chisina kujairika, zvikurukuru chinokanganisa vanhu vakuru.
Vanhu vakavhiringidzika vanotanga kuona kuvhara kana zvipembenene paganda. Kushanyira chiremba kunowanzokonzera chigadzirwa cheganda, icho chinotsigira kuongororwa. Zvidzidzo zvekucherechedza kune imwe molecule CD30 dzinodiwa kutora chirwere ichi seAALCL.
Vanenge 1 pa4 vanhu vane ALCL yeganda vashandura lymph nodes pedyo nehuputi hweganda kana maronda. Miedzo inogona kuitwa kuti itonge kunze kwechirwere mumapfupa uye mumimba. Chiyero chemapfupa emapfupa chinogona kuitwa sechikamu chekuongorora zvese.
ALCL yeganda rine maitiro akanaka kwazvo. Icho chirwere chinokurumidza kukura chisingatauri kutyisa upenyu.
Mune vamwe varwere, inogona kutopera kunyange pasina mushonga. Kune avo vane zvikopa zveganda zvishoma kunzvimbo duku, therapy inonzi radiation ndiyo kurapa kusarudzwa. Vaya vane ruvara rukuru rweganda vanogona kurapwa nehana shoma yezvinodhaka zvinonzi methotrexate, nenzira yemapiritsi emuromo kana injikisi.
Sources:
FDA Chibvumirano cheBrentuximab Vedotin, National Cancer Institute, July 1, 2013.
Childhood Hasi-Hodgkin Lymphoma Kuchengetedza-kune vashandi vehutano (PDQ®), National Cancer Institute, yakagadziridzwa 1/26/2016.
Munhu Mukuru Ari-Hodgkin Lymphoma Treatment-yevashandi vehutano (PDQ®). National Cancer Institute. yakarongedzwa 1/15/2016.