Immunohistochemistry (IHC) chirwere chakakosha chinoshandiswa nevanodzidza pathologist kuti vaone mahwendefa chaiwo pamasero.
Apo mhando yemaziso yakadai seyymph nodes biopsy inopfuudzwa kubhii rinofanira kuongororwa nokuda kwezvirwere, pane zvinhu zvakawanda zvisingagoni kutsanangurwa nyore nyore.
Zvirwere zvakasiyana-siyana kana zvirwere zvakasiyana-siyana zvinogona kutarisa zvakafanana kana kuti zvinoita seine masero akaenzana akafanana pasi pemakroscope asi ane maitiro akasiyana uye mishonga yakasiyana.
Imwe nzira yekuvatsanangurira ndeyekuona mahwendefa chaiwo pane aya masero anoshanda sezvikwangwani.
Immunohistochemistry inyanzvi inoshandisa zvirwere -kuchengetedza mamolekemu-iyo inogona kutsvaga, kuziva uye kuzvibatanidza kune idzi zviratidzo pamasero. Zvirwere zvepachiviriro pachavo zvakagadzirirwa kushanda nematekisi anogona kuonekwa kana kuonekwa pasi pemaikroscope, zvakadai sedhizirescent stain, iyo inobatsira kuita chisarudzo chaiyo.
IHC yakawana maitiro akawanda emishonga, kunyanya mukenza kuongororwa. Lymphomas ndevamwe vemakirini anonyanya kutarisana neHC yekutsoropodza kwakarurama uye kurapwa kwemishonga.
Zvimwe pane Immunohistochemistry
Zvimwe zvikamu zvehutano zvinogona kuonekwa nyore nyore nekudzidza masero ega ega uye maitiro avo, kusanganisira kuonekwa kwechikamu, mamwe mapuroteni emasero, uye chimiro kana "chimiro chechimiro" chesekeri, iyo inonzi s cell's morphology. Zvimwe zvikamu zvechirwere zvinomira kune uyo anotarisa chete apo mashungu anenge achifungidzirwa ari kuonekwa mumamiriro ezvinhu e "nzvimbo yose" yemasero.
Zvimwe zvinhu zvinoda mamwe maitiro ekuongororwa pamaseroti-mune mamwe mazwi, vanachiremba vanofanira kuziva nezvemamwe magadzirwa emagetsi-kushandiswa kweimwe majeni mumapuroteni, kana zviratidzo zvinogona kuonekwa nemasikirini.
Dzimwe nguva immunohistochemistry inobatsira kwete kungoziva rudzi rwemhando ye lymphoma asiwo kubatsira kubatsira kugadzirisa maitiro, zvichienderana nemararamiro anobatanidzwa nekunonoka-kukura mufambiro nehuwandu hunotyisa.
IHC yeLymphomas
Lymphomas inonzi inoratidzirwa ye lymphocytes iyo yakamira mumatanho akasiyana ekugadzirwa kana kusiyanisa, uye kushandiswa kweHC ine zvirwere zvakasiyana-siyana mu "panel" inobatsira kuziva mutsara chaiwo uye nhanho yekukura ye lymphoma.
Rimwe boka rezvirwere zvakasiyana-siyana rinoshandiswa kuona kuti ndezvipi zviratidzo zviripo pane lymphocytes. Izvi zvinowanzotanga netsamba dzeCD. Semuenzaniso, B-cell markers (CD20 neCD79a), T-cell markers (CD3 neCD5), uye mamwe mazita akaita seCD23, bcl-2, CD10, cyclinD1, CD15, CD30, ALK-1, CD138 inogona kushandiswa zvirwere zvakasiyana-siyana zvekenza kana hematologic malignancies.
Chimbofunga follicular lymphoma (FL) mune zvishoma zvakadzama sechimwe chezvinhu zvimwe zvinogona kuitwa neHCC. FL ndiyo yechipiri inonyanya kuiswa pasi ye -non-Hodgkin's lymphoma- yakakura huru B-cell lymphoma (DLBCL) ndiyo yakawanda kwazvo. FL ihwowo muenzaniso weiyo inozivikanwa se indolent lymphoma, zvinoreva kuti kanaya inoratidzika nekukura kwekukura uye kwenguva refu yekupona, kunyange pasina mushonga. Pane zvakawanda zvakasiyana-siyana zvakasiyana siyana zvekurapa kweFF, asi chirwere chinogona nenzira dzakasiyana chisingaenderani kubva kumunhu kumunhu.
Kune zvirevo zvekufananidzira, zvakadai seInternational Prognostic Index uye, kunyanya, Follicular Lymphoma International Prognostic Index (FLIPI) iyo inogona kubatsira kupa mifananidzo yemhando ipi yeFL iwe uri kutarisana nawo, uye kuti ingaita sei.
Pane imwe nguva, IHC kuongorora ye lymphoma uye "microenvironment" yayo yakadzidzwa kuona kana zviwanikwa zvingawirirana nemakiriniki akasiyana-siyana, maererano nekuongorora kwe2006 kwakabudiswa mu "Journal of Clinical Oncology."
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Alvaro T, Lejeune M, Salvadó MT, et al. Immunohistochemical patterns of reactive microenvironment zvinosanganiswa neklinikibiologic maitiro mu follicular lymphoma varwere. J Clin Oncol. 2006; 24 (34): 5350-7.
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