Targeted Therapy for Leukemia uye Lymphoma
Zvirwere zvemuviri wako zvinowanzobereka zvirwere zvinopesana nemasikirwo e 'tags' kune vanoparadza. Aya mavara ayo anowanikwa anonzi antigens. Zvirwere zvemuviri zvinogona kuziva maitiro ekurwisa mabhakitiriya nemaantijeni pamasero ako-kana vakave vane utachiwana hwehutachiona kana kenza, somuenzaniso. Apo an anti-antibody anosunga kune antigen yayo, inogona kuunganidza masimba ezvirwere kuti aparadze chinangwa.
Monoclonal antibodies, kana mAbs, anoshandiswa kurapa zvirwere zvakasiyana-siyana, kusanganisira mamwe marudzi ekenza. Pane zvakawanda zvekushandira pamusoro peAAbs uye zvingaita kuti vasarudze zvinokonzera kenza masero. Ichishandiswa pamwe chete nekemotherapy, mamwe maAbs akawedzerwa nguva yokupona.
Ko Monoclonal Inorevei?
Monoclonal zvinoreva 'clone imwe chete,' inoda kutsanangurwa. Kazhinji, apo muviri wako wechirwere chekuzvidzivirira uchiona muvengi, huchava nehutano hwakasiyana-siyana hwemishonga-dzose dzakasiyana-siyana, kutarisa mhando dzose dzakasiyana dzakasiyana-siyana pamusana pemuvengi. Izvi zvinopesana nemaprotyclonal antibodies, zvinoreva kuti 'maoneshoni' akasiyana-siyana kana mhuri dzemasero emumune anosanganisira kuedza kuita kuti muviri wose wezvirwere unorwisa varwi.
Masayendisiti ava kunyanya kunyanya kurwisana nekenza, uye kutarisa boka rezvinyorwa zvakasiyana-siyana , mazana nemakiti pamusana wekenza zvinogona kunzwa zvakanaka, asi hazvirevi chaizvo.
Somuenzaniso, zvakadini kana imwe yezvinangwa zvechirwere chekenza ichibuda kuti ivepo muhuwandu pane dzose dzakanaka, masero ane utano zvakare?
Monoclonal antibodies, ikozvino, inopesana nemaitiro anokonzerwa nebasa nemasayendisiti - masero anogadzirirwa kutarisa kune imwe chete, inozivikanwa antigen inofarira - kazhinji puroteni iri pamusoro pekenza masero.
Mienzaniso yemishonga yemabhadhi yekenza yeropa inosanganisira Rituxan (rituximab), uye Gazyva (obinutuzumab) , iyo yose inotarisa CD20 antigen. CD20 ndeimwe yezvinangwa zvakasiyana-siyana pamusoro peB-seli, kana B-lymphocytes, iyo inokonzera vakawanda lymphomas.
MaMonoclonal Antibodies Anoshanda Sei?
MAB anogona kushanda semabheoni, kana kuti zviratidzo, kuti aone maitiro ezvirwere zvekuzvidzivirira:
- Kusvibiswa kana kusagadzikana mAbs kusangana kune antigens pane kenza yekenza, kuita sechiratidzo chemuviri wechirwere chemuviri kutsva nekuparadza.
- Rituximab uye obinutuzumab mienzaniso yemhando iyi yeMAb. Vanoshandisa zvirwere zvemuviri wenyu kuti vauraye masero emukenza. Vanodzikisawo nhamba yehutano B-seli, dzine tereti yeCD20, asi utano hwema-B hunogona kugadziriswa.
MAB anogonawo kugadzirirwa kupa chinotyisa chebhadha pavanowana chinangwa chavo:
- Kugadziriswa mAbs kusungirirwa kune zvinokonzera sevana vasina kubata, asi vanopa zvinodhaka, chepfu , kana kuti rayation zvakananga kune kenza yesero.
- Muenzaniso weMAB conjugated ndeye Zevalin (ibritumomab tiuxetan). Zevalin inonzi CD20-inonzi radiotherapeutic mAb yekudzoka zvakare kana kukanganisa pasi-grade follicular B-cell kwete Hodgkin's lymphoma (NHL) . Iyo inoshandiswa zvakare kune yekare isati yashandurwa follicular NHL ine chikamu chisina kukwana kana chakakwana kumakemikirasiro epakutanga.
Ndezvipi Zvinonzi Monoclonal Antibodies Zvichipiwa?
Monoclonal antibodies inopiwa mukati, kuburikidza nemuviri, muchipatara kana kuchipatara. Mimwe mishonga inogona kupiwa nguva isati yasvika kuderedza mikana yekugadzirisa uye migumisiro.
Zvinonyanya kukosha, kana yakashandiswa sechirapa yeukweemia kana lymphoma, ma- antiocidal monoclonal anowanzopiwa pamwe chete nemasikirasiro evanhu. Nhamba yezviitiko zvakarongerwa, kana maitiro, ayo mAb anopiwa munguva yekurapa inobva kune zvakasiyana-siyana zvezvinhu zvakasiyana, kusanganisira zvimwe zvinhu zvingave zvakananga kwauri uye kurwara kwako.
Migumisiro Yechemu yeMococalal Antibodies
Kunyange zvazvo migumisiro yechirwere chemAbrapira haina kufanana neye chemotherapy, inoitika.
Dzimwe mimwe migumisiro inogona kunge yakangofanana nemagetsi e-type. Zvinosvibisa zvinogona kuvimba nemumwe mAb akapiwa, murwere mumwe nomumwe uye mamiriro ake ehutano huripo, rudzi rwekuvhiringidza uye zvimwe zvinhu zvakawanda. Mamwe maitiro anowanzobatanidzwa nemigumisiro anosanganisira zvinotevera:
- Mafivha, chills, zviratidzo zvinoputika
- Utsi husina simba kana kurwadziwa
- Headaches
- Nausea, kurutsa, uye chirwere
- Allergic reactions like rashes kana mikoko
- Sero rega rega rinotarisa , kunyanya iyo maAbs ayo akabatanidzwa nemirairo
- Matambudziko emwoyo, kudzvinyirirwa kweropa
Yashandurwa TI.
Sources:
> Abernathy, E. (1997). Biotherapy. MuVarricchio, C. (Mupepeti) A Kanzura Bhuku Revanamukoti -7th. (pp.379-390). Atlanta, Georgia: The American Cancer Society Inc.
> Battiato, L. uye Wheeler, V. (2000). Biotherapy. Mu Yarbro, C., Frogge, M., Goodman, M., et al (Eds.) Mazano eUkuchengetedza Kanzera uye Maitiro-5th ed. (pp. 1244-1269). London, England: Jones uye Bartlett Publishers International
> Iarocci, Thomas. Gazyva yeLin-Hodgkin's Lymphoma
> Iarocci, Thomas. Ropa Kanzi uye Anemia.
> NCCN. Murwere uye Mutevedzeri Resources. Targeted Therapies.
> RS Cvetkovic naCym Perry "Rituximab: A Review of Its Use in Non-Hodgkin's Lymphoma uye Chronic Lymphocytic Leukemia." Zvinodhaka 2006 66 (6): 791-820.