T-masero inhengo ye masero eropa eropa anoita basa rinokosha mumuviri wekudzivirira muviri uye kurwisa kenza. Ngatishandise masimba ezvirwere mumuviri kuti zvive nyore kunzwisisa.
Pane 2 mapoka makuru emasero machena (leukocytes): lymphocytes uye granulocytes.
Lymphocytes, zvakare, inoputsika mukati:
Type of Immunity
Mitumbi yedu ine 2 mazamu emhando yehutachiona hunowanikwa :
- Cell mediated immunity
- Kuzvidzivirira kwoutsinye
T masero ari chikamu chekuchengetedzwa kwemasero emumuviri, chikamu chemuviri wechirwere chemuviri iwe unogona kufungidzira sokuuraya zvakananga mabhakitiriya, mavairasi, uye kenza masero. Chimwe chimiro-hutachiona hunosunungura-hunodzivirira miviri yedu kubva kune avo vanopesana nekuita zvirwere.
Mhando dzeT-Cells
Kune marudzi mazhinji emasero eT, anosanganisira zvinotevera:
- Cytotoxic T masero - Cytotoxic T masero anowana uye anorwisa zvakananga vatorwa vakadai sebhakitiriya, mavairasi, uye kenza masero.
- Masero anobatsira T - Masero anonzi T anobata mamwe masero ezvirwere uye anoronga mhinduro dzomuviri.
- Masero ekudzivirira T - Masero Ekutungamirira anofungidzirwa kuti adzivirire masimba ezvirwere kuitira kuti arege kunyanyisa (sezvaanoita muzvirwere zvisingagumi), zvisinei kuti zvikamu zvepamusoro zve biology zvemasero aya zvinoramba zvakasvibiswa uye zvinoramba zvichirwisana.
- Muurayi wepanyama T - Maseru anouraya T (NKT) masero haasi chinhu chakafanana nemasero ekuuraya, asi ane zvimwe zvakafanana. NKT masero e-cytotoxic T masero anodikanwa kuti agadziriswe uye aparadzanise kuita basa ravo. Muurayi wechisikigo (NK) masero uye NKT masero ari mazana e-lymphocytes anogovera nzvimbo yakafanana. Vose vari vaviri vanokwanisa kukurumidza kupindura kuvepo kwemaitiro emarara uye vanobatanidzwa mukurwisa-tumoror immune response.
- Masero okuyeuka T - Masero eMemori T anoyeuka zviratidzo pamusoro pebhakitiriya, mavairasi, kana masero emukenza avakaona kare.
Kugadzira, kuchengetedza, nekuwanikwa
Mushure mekunge vabudiswa mumapfupa emasese , masero eT anotora nguva yakareba uye ichikura munhengo mubhokisi inonzi thymus-ichi ndicho chikonzero ivo vanonzi T-seli, izvo zvinomirira masemus e-derived. Mushure mokutsvaira, T-masero aripo muropa uye mune lymph nodes .
T-Cell Function muCcercer
T masero eT anobata basa guru mukurwa kwedu nekenza. Zvinogona kuvhiringidza kutaura nezvemasero eT, kunyanya kana tichitaura nezvekenza serymymia, saka tichaona nzira dzekuti T masero anoshanda kurwisana nekenza uye kuti angave akanganiswa nekenza sei. Kuti abvise kenza, kunyange kana pane maT cells akakwana, ivo vanofanira kutanga "kuona" kenza.
Nzira Mairi Memajira T Anoshandira Kurwisa Kanzera
Masero eT anoshanda nenzira mbiri uye nzira dzisinganzwisisi kurwisa kenza.
- Muurayi T masero anouraya masero emukenza zvakananga - Aya masero anotanga kuwana kenza yemukenza uye anogonawo kukurudzirwa kuuraya masero emukenza.
- Masero anobatsira T anorwisa kanzera pasina - Masero aya anoronga uye anoronga kurwisana nekenza.
Nzira Maitiro Api T Makero Anopindwa neKenza
- Kurumidza kubatanidzwa mukenza - Mukenza seT-cell lymphoma , maT cells anenge ane kenza.
- Bhoora marrow takeover - Lymphomas nedzimwe kenza zvinopararira kumapfupa emapfupa zvinokonzera masero ane utano mumashonga emafuta (zvirevo zvemasero eT) zvichiguma nekuderera kwemasero eT.
- Kuparadzwa nekuda kwechemotherapy - Chemotherapy inogona kukanganisa zvakananga T-masero nemamwe masero machena eropa.
Immunotherapy
Imwe nzira ichangobva kubuda inotsvakurudza tsananguro inosanganisira kugadzirazve unyanzvi hweT-seli dzemurwere kuitira kuti vaone uye vauraye masero ekenza. Rudzi urwu rwehutachiona rwakaratidza kuvimbisa kutanga kwekutanga mu lymphoma.
Kanzera-Kusachengetedzwa Kwemhepo
T masero ari chikamu chezvinozivikanwa sekenza-immunity cycle.
Sezvo kenza yemasera kufa, inosunungura antigens, zvinhu zvinogona kuzivikanwa nemusununguko wemuviri.
Antigens kubva mumasero emukenza anobva atorwa uye anounzwa pachitokisi chemasero ezvirwere anonzi immgen-presenting cells (APCs) kuitira kuti mamwe masero ezvirwere anokwanisa "kuona" antigens anofarira. Mune lymph nodes, APCs inobatsira T-masero uye inovadzidzisa kuti vaone tumarara masero. I-T-cell zvino inofamba nemidziyo yeropa kusvika padumbu, inopinda mukati, inoziva masero emukenza uye inovauraya.
> Sources:
> America Cancer Society. Chii Chitsva muCancer Immunotherapy Research? 11/05/15.
> Chen, D., uye I. Mellman. Oncology Inosangana Immunology: Cancer Immunity Cycle. Kusurukirwa . 2013. 39 (1): 1-10,25.
> Chen, D., Irving, B., uye F. Hodi. Molecular Pathways: Next Generation Immunotherapy - Inhibiting Yakarongwa Kufa-Ligand 1 uye Yakarongwa Kufa-1. Clinical Research Cancer . 2012. Itai: 10.1158 / 1078-0432.CCR-12-1362.