Statin zvinodhaka, zvinoshandiswa pakuderedza cholesterol , ndezvimwe mishonga inowanzonzi yakagadzirirwa munyika yakagadzirwa. Kunyange zvazvo statins inowanzove yakanyatsobvumirwa, migumisiro yakaipisisa yakawanda inowanzobatana nemakumbo emakumbo, chiitiko chinonzi "statin myopathy".
Ndezvipi Zviratidzo zveStatin Myopathy?
Statin myopathy inowanzoita imwe yemhando mitatu:
- Myalgia - kurwadziwa kwemisungo - inowanikwa ne2% kusvika ku10% yevanhu vanotora mitemo. Statin-induced myalgia inowanzoonekwa sekuneta, kazhinji mumapfudzi nemaoko, kana mahudyu nemahudyu. Inowanzowirirana nekuneta zvishoma.
- Myositis - kusuruvara kwechiremera - kunoitika munenge mune imwe vanhu 200 vanotora mazita. Myositis inokonzera marwadzo ekurwadziwa, pamwe nekukwirira kweCK mazinga muropa. CK inyenzi yeutema, uye kuvapo kwayo muropa kunoratidza kuti kunyanya musimba kunokonzerwa.
- Rhabdomyolysis inokonzera kukuvadzwa kwemisimba - kunyanya kuparara kukuru kwemashuga emuviri - zvichiita kuti kusununguka kukuru kwemapuroteni emuviri muropa, izvo zvinogona kuunza kukanganisa kwakakomba kwetsvo uye rufu. Rhabdomyolysis inokonzerwa nemasimoni, nerufaro, inonyanya kuwanikwa, ine nyaya imwe chete inowanikwa kune mamiriyoni gumi emitemo yakanyorwa yakanyorwa.
Kana zvipingamupinyi zvematumbo zvichiitika, zvinowanzotanga mukati memavhiki mashomanana kusvika kumwedzi mishomanana mushure mekutanga statin therapy.
Statin-related myalgia uye myositis zvose zvichagadzirisa mukati memavhiki mashomanana kana chirwere cheteminini chiri kubviswa. Rhabdomyolysis ichagadzirisa zvakare mushure mokunge statin imiswa, asi kukanganisa kunokonzera kungave kusingagoneki.
Nepo kune mazano mazhinji, hapana anoziva nechokwadi nei zvipfeko zvinogona kuunza matambudziko emasumbu.
Statin myopathy zvichida ine chokuita nekushandurwa kwekuti masumbu anogadzira sei kana kushandisa simba. Kusvika ikozvino, vatsvakurudzi havana kukwanisa kuitora zvakanyanya kupfuura izvozvo nehupi hupi hwekuvimba.
Dzidziso iyo yakagadziriswa zvikuru nevanhu vakawanda ndeyekuti mitemo inogona kupindira nekugadzirwa kweCQ10, coenzyme mumasumbu. CoQ10 inobatsira masumbu kushandisa simba ravanoda kuti riite. Zvimwe zvidzidzo zvishomanana zvakaratidza kuti kutora CoQ10 zvinowedzera kunogona kuderedza kusangana kwematambudziko emasimoni anokonzerwa nemasitemu, asi data (zvose zviri zviviri kana zvinyorwa zvichitadzisa maQQQ10 uye kana CoQ10 kuwedzera kuibatsira) yakanyanya kusimba.
Zvidzidzo zvenguva pfupi zvakaratidza kuti matambudziko emasumbu ane statins anonyanya kuitika kuvanhu vane vitamin D inoshaya . Vamwe vakaona kuti kutungamirira vitamini D kune vanhu ava kunobatsira kugadzirisa zviratidzo zvemasimoni zvine chokuita nemasimoni.
Zvinokonzerwa Nengozi Nokuda Kwematambudziko Matambudziko
Matambudziko emasumbu nemasimoni akawandisa kune vanhu vari kutorawo Lopid (gemfibrozil) , steroid, cyclosporine, kana niacin.
Vanhu vane chirwere chisingaperi chepfungwa, chirwere chechiropa, kuderedza mavhitamini D mazinga, kana hypothyroidism zvinowanzosangana nematambudziko emasumbu nemasimoni, sezvakaita vanhu vane chirwere chemasumbu chinokanganisa seamyotrophic lateral sclerosis (ALS) .
Mimwe mitemo inowanzoita sokuti inokonzera zvinetso zvemasumbu kune vamwe. Kunyanya, zviitiko zvematambudziko emasumbu zvinogona kunge zvakakwirira nepamusoro-dose simvastatin (zita rezita Zocor) kupfuura mamwe maitiro emishonga.
Nokuda kwechikonzero ichi, munaJune 2011, Kudya uye Drug Administration yakakurudzira kuti mukana wekufananidzirwa uwane 40 mg pazuva. Pachiitiko ichi, chiitiko chematambudziko emasumbu ne simvastatin hachiratiki sechinyanya kukwirira.
Ngozi yematambudziko emuviri inoita sokuti haina zvishoma ne Lescol (fluvastatin), Pravachol (pravastatin) uye pamwe Crestor (rosuvastatin). Kana unyoro-hunoenderana nemigumisiro yakaipa inowanikwa nedzimwe mitemo, kushanduka kune rimwe remishonga iyi rinogona kugadzirisa dambudziko racho.
Statin myopathy ingangove yakanyanya kuitika kune vanhu vanoita basa guru, kunyanya kana vachidaro vasina kuvaka kwariri zvishoma nezvishoma.
Ndezvipi Matambudziko Anosangana neSatani-Matambudziko Anotariswa?
Kazhinji, kana dambudziko rehutano rinosangana nemafungiro rinofungidzirwa, vanachiremba vachamira mutemo wemishonga, zvichida kusvikira dambudziko remasumbu rinogadzirisa. Chirongwa chinofanirwa kuitwa nokuda kwekushaya kwevhitamisi D uye hypothyroidism, pamwe chete nekubatana kwezvinodhaka izvo zvinogona kuwedzera matambudziko anokonzerwa nemasitemu. Chero chezviitiko izvi zvinopisa zvinowanikwa zvinofanira kuongororwa.
Kana zviratidzo zvakasangana nemasumbu zvinosanganisira marwadzo uye zvichida kukwirira kuduku mumakirwe eropa, uye kana kupfuurirwa kwetachiona rematoriko kuchionekwa sekukosha, kune nzira shomanana dzingabvumira kubudirira zvakare kwechimiro.
Chokutanga, kuchinja kune chimiro chinonyanya kusakonzera kukonzera matambudziko (musingazivikanwi ne pravastatin kana fluvastatin) kanowanzobvumira munhu ane dambudziko rematambudziko kuti atore statin kubudirira. Uyewo, kurondedzera chimiro chemishonga zuva rimwe nerimwe, panzvimbo yezuva rimwe nerimwe, kwakabatsira kune vamwe vanhu vasingakwanisi kubvumira zuva rega rerapi. Pakupedzisira, nepo nyanzvi dzakawanda dzisingatendi kuti CoQ10 kubatsiridza kunobatsira mukugonesa patsva remutemo wetemineni, pane mharidzo dzakapararira kuti izvi zvinogona kubatsira.
Shoko Rinobva
Kunyange zvazvo mishonga yechipfuva iri dambudziko rinowanzoonekwa nemasimoni, izvi zvinokonzerwa nemigumisiro yakawandisa kune vanhu vasina mari yakawanda yezvikonzero. Uyezve, uye pavanenge vachiitika, zvinetso zvematumbo zvinenge zvichishandurwa nguva dzose. Zvinetso zvinotyisa zvemasumbu kubva kune zvinyorwa hazvishamisi zvakanyanya.
Kunyange zvakadaro, kana iwe uri kutora mutemo wemishonga iwe unofanirwa kuziva kuti iwe unogona kuwedzera kurwadziwa kwemasisita kana utera, uye kana zviratidzo izvi zvichiitika iwe unofanira kuzviunza kune chiremba wako.
> Sources:
> Gupta A, Thompson PD. Ukama hweVhitamin D Kukwana kuStatin Myopathy. Atherosclerosis 2011; 215: 23.
> Rosenson RS, Baker SK, Jacobson TA, et al. Chiongorori neStatin Muscle Safety Task Force: 2014 update. J Clinic Lipidol 2014; 8: S58. T
> Stroes ES, Thompson PD, Corsini A, et al. Statin-Inosanganiswa Mumuviri Symptoms: Impact pa Statin Therapy-European Atherosclerosis Society Consensus Panel Statement pamusoro pekuongorora, Aetiology uye Management. Eur Heart J 2015; 36: 1012.
> Thompson PD, Clarkson PM, Rosenson RS, National Lipid Association Statin Mushonga Wekuchengetedza Mushonga Wezvokuchengetedza Mushonga Wezvikamu Panzvimbo. Chiongorori Chekuchengeteka kweStatin neMashamba Nyanzvi. Am J Cardiol 2006; 97: 69C.