Ezetimibe mishonga inoderedza cholesterol mazinga . Ive yava FDA yakagamuchirwa kubvira muna 2002, uye inotengeswa semuiti-oga mishonga (Zeta) pamwe chete ne simvastatin ( statin drug) sezvakaitwa Vytorin. Zvisinei, ezetimibe yakave ichikakavadzana kubvira pakatanga kushandiswa, uye nyanzvi dzichiri kukakavadzana pamusoro penzvimbo yayo yakakodzera mukurapa kwezvinetso zvemapidhi.
Ezetimibe
Ezetimibe inoshanda nekudzivirira kuvhara kweku cholesterol kubva mumatumbu.
Kazhinji, cholesterol yakabatwa kubva mumatumbo inotakurwa nema chylomicrons kuchiropa, umo inoshandiswa kwezviitiko zvakakosha zvinoita. Apo chiyero che cholesterol chakakodzwa chinoderedzwa ne ezetimibe, chiropa chinofanira kupiwa kwayo cholesterol nokuchibvisa kubva pamapoproteins ari kubuda muropa. Nokudaro, huwandu hwehushuga hwehushutera hunoderedzwa.
Kazhinji, ezetimibe pamwe pachayo kana kusanganiswa nesiminono inoderedza kuwanda kweLDL cholesterol muropa ne inenge 15%.
Migumisiro Yakaipa yeEzetimibe
Kazhinji, ezetimibe inobvumirwa zvakanaka. Nausea, chirwere chemahara, uye zvinokonzerwa nezvinokonzera zvinogona kuitika. Kunyange zvazvo myopathy (musimba migumisiro) yakave ichitaurirwa ne ezetimibe, yakafanana neyemyopathy inowanikwa nemasimoni , chiitiko chechinetso ichi chinoratidzika se chakanyanya kudarika pane mitemo. Kutaura zvazviri, ezetimibe inogona kuwedzerwa kumutsetse wepamusoro-dose kuitira kuti uwane cholesterol yakakosha kuderedza pasina myopathy dzimwe nguva inoonekwa nepamusoro-dose mitemo.
Kurwisana neEzetimibe
Apo ezuvamibe yakatanga kugamuchirwa, yakatengeswa zvikuru seVotorin (ezetimibe uye simvastatin), uye kutengesa kwaive kwakashata. Iwe unogona kuyeuka zvikwereti zvinowanzoitika panguva iyo uchifananidza sweet sweet, rotund Amainini Suzie kune chikamu chiduku cheswiberi shoka la mode. Icho chainzi Vytorin.
Izvi zvinosvika kuti, apo izvo zviziviso zvaive zvichimhanya uye apo Merck aitengesa mabhiriyoni emadhora eVytorin, bhuku rakange rakanonoka (kunyunyuta, vamwe vakati) rwechirongwa cheMerck-chakatsigirwa chirongwa chinonzi ENHANCE kudzidza. KUSUNGWA kwaiva nechinangwa chekuratidza kuti Vytorin akavandudza atherosclerotic plaques kupfuura simvastatin chete. Apo migumisiro yakazobudiswa muna 2008, yakadzidziswa kuti vanhu vakabata naVaVittorin vakaita zvishoma nezvishoma (kwete nani) kune avo vanogamuchira simvastatin chete.
Nokuda kwemigumisiro iyi isina kunaka (uye kuti vakawanda vanofunga kuti kunonoka pakuzivisa izvo zvigumisiro zvinenge zvisiri izvo zvisingaitiki), kutengesa kwe ezetimibe tanked. Uye zvikwereti zvakanyangarika zvachose.
Kufarira ku ezetimibe kwave kwakadzoka kusvika pamwero kubva muna 2014, apo migumisiro yeIPRPR-T IT yakazobudiswa. Muchiitiko ichi, varwere vane acon coronary syndrome (ACS) vakashandurwa kuti vawane kana Vytorin kana simvastatin chete. Mushure memakore matanhatu, varwere vakagamuchira Vytorin vakanga vachinatsa zvishoma nezvishoma zvikwereti zvemakiriniki (zvishomanana kuverengwa nokuda kweAACS, uye zvishoma zvaidiwa zvekuzovhiyiwa kwepamusoro kana kupisa ), asi pakanga pasina mutsauko mukupona.
Chikamu chekuongororwa kweICHINHU-Chiitiko chakaratidza kuti zvinenge zvose zvakabatsirwa muboka reViktorin zvingaverengerwa nevarwere vane chirwere cheshuga.
Muvanhu vasina chirwere cheshuga, hapana kubatsirwa kubva kuwedzera ezetimibe kunogona kuratidzwa.
Ezuvamibe Inofanira Kuitwa Rini?
Muzhinji, kushandiswa kwe ezetimibe kunofanira kunge kwakanyanya. Mirayiridzo yakabudiswa mugore ra2013 pamusoro pekushongedzwa kweklesterol haifaniri kukurudzira kubata kune chero ipi zvayo inokonzera cholesterol level. Pane kudaro, vanoisa pfungwa pakusarudza kana kushandisa sriminachirwere kana kwete. Saka "chipiri" cholesterol-kuderedza zvinodhaka se ezetimibe zvine nzvimbo shoma pasi pemitemo iyi. Vanachiremba dzimwe nguva vanopa ezetimibe uye pasi-dose mitemo muvanhu vanofanirwa kunge vari pamusoro-dose mitemo, asi havagoni kushivirira mizinga yakakwirira.
Uyezve, ezetimibe dzimwe nguva inoshandiswa panzvimbo yezvimiso muvarwere vanongokwanisa kutora statines pane chero muroti.
Pakupedzisira, pamusana peIPRPRESS-IT, vazhinji vanoona nezvemapurisa vanoona zvakanakira kushandisa ezetimibe pamwe nemufananidzo wevarwere vane chirwere cheshuga avo vane ACS yemazuva ano.
Kunze kwezviitiko izvi zvishoma zvemakiriniki, pane ikozvino haisi chikonzero chikuru chekutora ezetimibe.
> Sources:
> Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Yakawedzerwa kuStatin Therapy pashure peActute Coronary Syndromes. N Engl J Med 2015; 372: 2387.
> Kastelein JJ, Akdim F, Stroes ES et al .; KUBATSIRA Vatsvakurudzi: Simvastatin Nayo kana kuti Pasina Ezetimibe muHome Hypercholesterolemia. N. Engl. J. Med. 358, 1431-1443 (2008).