Kana cholesterol yave iri dambudziko kwauri, chiremba wako angave akakuudza pamusoro peZetia (ezetimibe) kana kuti Vytorin (ezetimibe plus simvastatin). Vytorin yakagadzirwa sekubatanidza Zetia uye Zocor (simvastatin), iyo yakanga yakagadzirirwa kuwedzera nzvimbo dzeZocor yekurwa.
Kuvhiringidza? Ingoyeuka kuti Zocor inongova statin - rudzi rwemishonga inoshanda muchiropa kuti kudzivirira cholesterol kusagadzikana.
Zetia mishonga mitsva, yakagadzirirwa kudzivisa kubatwa kweklesterolori kubva pakudya mumatumbo. Vytorin inobatanidza zvose Zocor uye Zetia.
Vytorin akaudzwa kuvanhu vose muna 2004 kuburikidza nemashamba eTV anonzi Vytorin aigona kurwisa zvinhu zviviri zveku cholesterol: zvokudya uye majini. Vytorin akabatana nemishonga yehushutera yeklesterori yakanga yava kutowanika pamusika, asi nemutengo wakaderera. Zvisinei, kutengesa kwakanyanya kweZetia, uye gare gare, Vytorin, vakakurumidza kuisa mishonga yeCholesterol yeUnited States yemishonga iyi.
Clinical Trials Have Mixed Results for Zetia and Vytorin
Zetia naVivtorin vakatanga kubvumidzwa neDFA muna 2002 uye 2004, pamwe chete, pamusana pekugona kwavo kuderedza "yakaipa cholesterol" ( LDL ). I "cholesterol yakaipa" inofungidzirwa kuti inokonzera kugadzirwa kwepakisi pamasvingo ekugadzirisa zvinogona kutungamirira kurwara kana kushaya mwoyo.
MunaJanuary 2008 , Merck / Schering Plow Pharmaceuticals - muiti weZetie naVivtorin-vakabudisa migumisiro yekudzidza pamusoro pemigumisiro yekubatanidzwa kwe ezetimibe uye nepamusoro-dose simvastatin nekuenzanisa simvastatisi bedzi pane chirongwa che atherosclerotic muvarwere vane heterozygous mhuri ye hypercholesterolemia , inonzi CHIDZIDZO.
Ichi chidzidzo chakafananidza varwere 720 vanotora vaVivtorin kana kuti Zocor chete. Nokushandisa ultrasound kuti iongorore mishonga yemitsipa yevarwere ava kubva kumapoka acho ose, vatsvakurudzi vaitarisira kuongorora kana kusanganiswa kwemishonga, Vytorin, kwakaderedza chiitiko cheplate buildup mumishonga yavo.
Mutarisiro ndewokuti avo vanotora vaVytorin vaizoonekwa kuti vane zviduku zvishoma pamasvingo avo ekugadzira kune avo vakatora Zocor oga.
Pane kudaro, kugadzirisa kwechidzidzo chacho kwakaratidza kuti varwere veVivtorin vakanga vasina zvichemo zvishoma mumishonga yavo kupfuura avo vanotora Zocor chete. Kutaura zvazviri, avo vaitora vaKvtorin zvechokwadi vakanga vaine zvinyorwa zvishoma.
Mashoko Akanaka MuChidzidzo cheChipiri
Chidzidzo chechipiri, chinonzi "Improved Reduction Results": Vytorin Efficacy International Trial (IMPROVE-IT), zviyero zvakaenzana mune vanopfuura 18 000 varwere vakange vambove nekurwadziwa kwepfungwa. Migumisiro yenyaya iyi, yakashumwa muna 2014, yakanyanya kuwedzera varwere paVivtorin ezetimibe / simvastatin regimen vakazadzisa zvinangwa zvavo zvose zveLDL-C uye hs-CRP kupfuura avo vari simvastatin chete. Vaiva nemigumisiro yehutano huri nani kana vakawana zvinangwa zviviri, sekuenzaniswa nehutano hwepfungwa, chiitiko chikuru chegoni, kana kurohwa. Dambudziko ravo rekudzoka kwepfungwa yemwoyo kana kuti kurohwa kwakaderedzwa ne 6%. Chirwere ichi chakabatana hachina kuratidza zvikanganiso zvakashata, kunyanya pangozi yekenza.
Izvi zvakaramba zvichiita kukakavara - zvakakosha here kutora mishonga inoita kuti mabhiza ako aoneke zviri nani, asi ane zvishoma zvishoma nezvehutano hwako, kana pane?
Vytorin akanga ane nyevero uye zvidziviriro zvakawedzerwa muna 2010 uye zvakarongedzerwa nguva dzose kuti nyevero pamusoro pehuwandu hwekushaya myopathy / rhabdomyolysis. Izvi zvinosanganisira nyevero dzeizvi mumubatanidzwa neaiacin uye fibrates.
Ndinofanira Kusiya Kutora Zetia kana Vytorin?
Kwete nekukurumidza. Arterial plaque parutivi, varwere veVivtorin vakaita zvakanaka chaizvo mune imwe chiyero, kureva kuti, kuderedza maitiro e "cholesterol yakaipa," iyo ndiyo mhinduro yakafanana iyo yakakunda FDA kubvumidzwa pakutanga. Kuenzaniswa nevarwere veZocor, varwere vaViktorin vakaona kudonha kwe "cholesterol yakaipa". Nekuda kweivo vaVittorin varwere mukudzidza vakave nechepasi "zvakaipa cholesterol" mazinga asina kuvandudzwa mu arterial plaque haisati yanyatsonzwisiswa. I-FDA iri kuramba ichitsvaga uchapupu huno.
NezveZetia, zvidzidzo zvekare zvave zvaratidza kuti ichi chirwere chinobatawo zvishoma kuderera kwe "cholesterol yakaipa".
Kunyange kana isingasanganiswi neZocor, avo varwere vachitora Zetia vakaita seva nemigumisiro iyo yakadzivisa kubatwa kweklesterolori kubva kune zvokudya zvinopfuura mumatumbo.
IAmerican Heart Association yakayera panyaya iyi kuburikidza nevarwere vanotora Vytorin kuti vasarega kurapwa nekuda kwedambudziko rehuwandu hwehutano hwehutano kubva pakurumidza kupedza cholesterol kurapwa. Kunyange kutengesa kune imwe mishonga inogona kunge isingakoshi kune zvikonzero zvinoverengeka:
- Kunyange nemigumisiro inogumbura yekudzidza kwokutanga, Vytorin haana kuratidzwa kuti haana ngozi.
- Izvo zvinyorwa zviri muVivtorin zvine mazano akawanda anoratidza kwenguva refu ekurwisa cholesterol.
- Vytorin kana Zetia vangave vakagadzirirwa kune vamwe varwere nokuti Zocor kana imwe sarimeni pachaga yakanga isingakwanisi kuderedza "yakaipa" cholesterol. "
- Mamwe mishonga ingangodaro isina kubatsira kune vamwe varwere, nekuda kwemamiriro ekurapa asina kukodzera.
Zvaunofanira Kuita
Sezvenguva dzose, unofanira kutarisa nachiremba wako. Bvunza kana kune mamiriro ezvinhu anofanira kukuchengetedza pane nzira yezvino yekurapa kana iwe unofanira kutanga kutarisa dzimwe nzira.
Kana chiremba wako akakurudzira kuti iwe ugare mukana naVa Vytorin kana Zetia, iwe unofanirwa:
- Ramba uchichitevera mararamiro anoraramisa mararamiro ekudya , kuita muviri uye kusvuta kusachengeta kuchengetedza cholesterol yako.
- Chengeta zvawakagadzirisa uye ucherechedze chero kuchinja kwepanepa yako yemapurisa kuti uone kana mushonga wako wemishonga uri kushanda sezvaunotarisirwa.
- Chengetedza zviratidzo zvezuva nezuva uye udzoke chero mimwe migumisiro yaungangodaro uchitarisana nachiremba wako.
Heano zvimwe zvingava nemigumisiro yekutarisa paunenge uchitora Vytorin:
- headache
- musuru kana kurwadziwa
- zvose zvinokonzera kugadzikana, kusanganisira rashes kana kutuka
- zviratidzo zvechiropa kana kuti gallbladder kuputika, kusanganisira kurwadziwa kwepamuviri uye muto usina kukodzera marara nezvigaro
I-FDA iri kuramba ichiongorora zvitsva zveongororo kuti ione kana chiito chipi zvacho chakakodzera. Kana iwe uchidavira kuti wakatambudzwa nemigumisiro, kana iwe wakamboona chiitiko chakaipa chakadai sechirwere chemwoyo kana chirwere, paunenge uchitora Vytorin kana Zetia, unokumbirwa kuudza iyo kuDWW's MedWatch Adverse Event Reporting program online.
Sources:
American Heart Association Staff. "Kurapa Kwemishonga yeCholesterol." AmericanHeart.org . 4/21/2014. American Heart Association. February 11, 2016.
American Heart Association Staff. "Nyaya inobva kuAmerican Heart Association pamusoro pekudzidza ENHANCE mhinduro." AmericanHeart.org . 15 Jan. 2008. American Heart Association. 29 Mar. 2008
Jackevicius, Cynthia. "Kushandisa Ezetimibe muUnited States uye kuKanada." New England Journal of Medicine . 28 Mar. 2008. New England Journal of Medicine. 3 Apr. 2008.
US Food and Drug Administration Staff, "Kukurukurirana Kwepakutanga pamusoro peChirwere Chekuongorora Dhiyabhorosi yeEzetimibe / Simvastatin (inotengeswa seVytorin), Ezetimibe (inotengeswa seZetia), uye Simvastatin (inotengeswa seZocor)." FDA.gov . 25 Jan. 2008. US Food and Drug Administration. 29 Mar. 2008.
US Food and Drug Administration Staff, "Inside Clinical Trials: Kuedza Kurapa Mishonga Muvanhu." FDA.gov . 1 Sep. 2003. US Food and Drug Administration. 3 Apr 2008
US Food and Drug Administration Staff, "Vytorin (ezetimibe / simvastatin) tablet." FDA.gov . February 2014. US Food and Drug Administration. February 11, 2016.
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