Paunofunga nezvenguva refu yekuguma kwekusvuta, iwe unowanzofunga nezvemapapu nekenza. Zvisinei, kusvuta kunogona kukanganisa zvimwe zvehutano hwako kusanganisira moyo wako wehutano.
Kana zvasvika kune cholesterol , hazvisi izvo zvinopinda mudumbu; iyo zvakare pamusoro pezvinoenda mumapapu. Kunyange zvazvo zvingava zviri nyore kunzwisisa kuti kusvuta kunogona kutongwa sei nemamiriro ezvinhu akaita sekenza yemuromo, kenza yemapapu, uye emphysema, utsi hwefodya hunokonzera sei cholesterol uye chirwere chemwoyo?
Ngarave dzine inokonzera yehupfu, kusanganisira yakanyanya kushandiswa kwemakemikari inonzi acrolein. Acrolein isimbi, inonhuwira inonhuwira inogadzirwa nemiti inopisa, sefodya. Ikowo yakagadzirwa nevanhu uye inonyangadza zvokuti inoshandiswa mune zvose zvinouraya uye makemikari zvombo. Acrolein iri nyore kupinda muropa mumapapu, uye masayendisiti anotenda kuti inobatsira kuti chirwere chemwoyo chive nechinokanganisa nzira iyo muviri inoshandiswa nayo inogadzirisa cholesterol.
Cholesterol Basics
Pasinei nemazita aro asina kunaka, cholesterol inowanzoitika, mafuta muviri yedu inobudiswa nechiropa uye inobatsira nekutakura kwehomoni uye kudya kudya. Cholesterol inofamba neropa mukati meviri mapuroteni akasiyana akashanda.
Low-density lipoprotein (LDL), iyo inonzi "yakaipa cholesterol," inopa cholesterol mumuviri wose uye yakakura-density lipoprotein (HDL), inozivikanwa se "yakanaka cholesterol," inounganidza mafuta uye inodzorera kuropa.
Kuti uchengetedze mwoyo wakagadzikana, American Heart Association inorayira kuchengeta maLDL mazasi pasi pe 100 mg / dL, HDL mazinga ari pamusoro pe 40 mg / dL, uye akabatana nemazinga ari pasi pe 200 mg / dL.
Kudya zvakawanda zvekudya zvakanyanya-mafuta zvinogona kukwanisa kuita izvi, uye kutsvakurudza kwemazuva ano kunoratidza kuti kusvuta kunogonawo. Acrolein inopesana nekukwanisa kuchenesa HDL nekurwisa mapuroteni.
Mugumisiro: Mafuta akawanda anowedzera muropa uye mukati mimwe yose yomuviri.
Maitiro eAcrolein muCigaretti Anokanganisa Cholesterol
Acrolein inopindirawo neLDL nekudzivisa enzyme inodzivirira inobatsira kuchengetedza LDL yakasimba. Pasina iyi enzyme, iLDL inowanzosvibiswa nekusanganiswa, inyanzvi yemakemikari inoshandura inoshandura maitiro ayo. Nokuda kwekushanduka uku mugadziriro, maitiro ezvirwere zvekuzvidzivirira pasi haakwanisi kuziva LDL. Mukupindura kweizvi, maitiro ezvirwere zvemusununguko anosunungura masero machena eropa nemamwe zvirwere-kurwisa zvinhu zvinosungira munzvimbo inobatwa, zvichikonzera kuvhiringidza nekuwedzera kuvaka panzvimbo. Chimwe chidzidzo chakawana kuti iyo yakawanda yeLDL yakasanganiswa iri muropa, iyo inowedzera chiitiko chekurwadziwa kwepfungwa kana chirwere.
Genetic Predisposition for Disease In Smokers
Kunyange zvazvo tsvina inotanga mumapapu inenge yakafanana kune munhu wose anoputa, kuti inokanganisa sei muviri inogona kusiyana zvikuru pakati pevanhu ava. Chidzidzo che2007 chinoratidza kuti zvizvarwa zvepabonde zvinoita basa rinokosha muhutano hwepfungwa kune ngozi kune vamwe vanoputa.
Vatsvakurudzi veYunivhesiti yeRochester vakawana kuti 60% kusvika ku70% yehuwandu yevanhu vane ruzivo rwemajeni muhutachiwana hunenge huine chikamu cheHDL kuLDL.
Izvi zvinonzi cholesterl ester transfer protein (CETP). Kunyange zvazvo kushanda kwaro kusina kunyatsonzwisiswa, masayendisiti anotenda kuti CETP inobatanidza kutumirwa kweHDL kuLDL cholesterol.
Chiremera chemajini chinokonzera CETP kushanda mukudarika, kurwisa HDL nekuiputsa iyo zvikamu zvinogona kubviswa nyore nyore kubva muropa. Izvi zvinoderedza huwandu hweHDL.
Nokuti kusvuta kunozivikanwa nekuderedza huwandu hweHDL, vanyori vekudzidza vanocherechedza kuti kuwedzerwa kwekufuta kwevose kusvuta uye chiremera chemajini kunowedzera dambudziko rekudzivirira chirwere chemwoyo. Chidzidzo chacho chakawana kuti vanosvuta neine genetic defect "vanogona kutambura nepfungwa yekuora mwoyo makore gumi nemaviri apfuura kupfuura munhu asiri kusvuta." Vakasvuta vasina kutakura zvinokonzerwa nehutachiona hwemajini vane mukana mumwechete wekushaya chirwere chemwoyo sevasingafungi.
Mabheji akavharwa Anotungamirira Kuhutano Hwepfungwa
Pasinei nokuti zvinoitika sei, cholesterol buildup mumutumbi inzira yehutano hwemwoyo.
Zvose zvinokonzerwa necholesterol uye maLDL zvinowedzera dambudziko rekuputika uye mutsvuku weropa rekudzivirira hunozivikanwa seplate (kwete zvakafanana neketani pameno ako). Pakutanga, arterial plaque buildup inoramba iri nyore. Nokufamba kwenguva, zvisinei, zvinogona kuoma uye kunyange kuputika, zvichiita kuti ropa rivhare.
Iyo yakanyanya kuiswa uye kuvhara mukati mumiririro, zvakaoma kuti ropa rifambe mumuviri wose, kumanikidza mwoyo kushanda zvakaoma kuwana oxygen nemuviri kumuviri. Sezvo mitsetse yakavharidzirwa-chiitiko chinonzi atherosclerosis - kufambira mberi, zvikamu zvemuviri zvinogona kutapudzwa kuderera kweropa.
Kuwedzerwa kweropa kunopfuurira kusvika pamwoyo, inozivikanwa segononary artery disease , ndicho chinokonzera rufu rwekuAmerica. Stroke, chimwe chikonzero chinowanzokonzera rufu, chinokonzerwa nekuderera kweropa kuderera kuuropi.
Kunyange zvazvo kusvuta tsika kunobatsira mukutengesa kweklesterol uye chirwere chemwoyo chinokonzera njodzi, kudya uye basa rekuitawo chimwe chinhu. Vanhu vari kutsvaga mazano ekurega kurega kusvuta kana kuderedza cholesterol mazinga vanofanira kutaura nevanopa utano hwavo.
Sources:
> Goldenberg I, Moss AJ, Block R, Ryan D, Corsetti JP, McNitt S, Eberly SW, Zareba W .. "Polymorphism mu cholesterl ester kutumira protein gene uye pangozi yekutanga myocardial infarction pakati pezvinoputa fodya." Ann Noninvasive Electrocardiol. 2007 Oct; 12 (4): 364-74.
Lifestyle Changes uye Cholesterol. American Heart Association, Gumiguru 26, 2015.
> Yang H, Mohamed AS, Zhou SH. "Oxidized > low density > lipoprotein, masero emasero, uye atherosclerosis." Lipids Health Health Dis. 2012 Jul 2; 11: 85. doi: 10.1186 / 1476-511X-11-85.