Sarudza Dambudziko Rako Rokukura Dambudziko reCeliac
Chirwere cheCeliac chinobatanidza nekuzvarwa, zvichireva kuti iwe unogona kukura celiac kana iwe uine majee anowanzosimudzira iwe. Nokudaro, vanachiremba vanowedzera vari kushandisa chirwere chechiliac chirwere chekuongorora kuongorora kana mumwe munhu ane chigadziro chekuvandudza mamiriro acho.
Munenge wose munhu wese anodya gluten, puroteni inowanikwa muzviyo zvegorosi, nebhari uye rye.
Zvisinei, kune vanhu vane maitiro echokwadi, gluten ingestion ingaguma ichitungamirira kune chirwere chechiliac, chimiro chemoto chinokonzera kuti zvirwere zvako zvichirwa nemasero eropa zvirwere kurwisa rwonzi rwemukati mako.
Haasi munhu wose anotakura chirwere checalyac genes pakupedzisira achakura chirwere chechiliac-chaizvoizvo, nepo kusvika ku40% yevanhu vane imwe kana kuti maviri emajini anodikanwa, 1% chete yevanhu vechokwadi vane chirwere chechiliac. Saka kuva nehutano hwemazwi hazvirevi kuti uchazoonekwa nechirwere cheecliac uye unoda kurega gluten; muzvokwadi, maitiro akaiswa pairi.
Zvisinei, kuongororwa kwemazwi echirwere chechiliac kunogona kupa chimwe chikamu kune chipikicha chekuongorora, kunyanya mumamiriro ezvinhu apo kuongororwa kwako hakusi pachena-kutema kana kuti uri kuedza kutsvaga zvido zvekuuya mune ramangwana.
Dambudziko reCeliac Genetic Testing Rinotarisa Zviratidzo zviviri
Ita neni-izvi zvinowanzooma.
Majini anowanzoita kuti uve nechirwere chechiliac ari panzvimbo yeHLA-class II yakaoma yeDNA yedu, uye inonzi inozivikanwa sejena reDQ.
Munhu wose ane makopi maviri eDQ gene-imwe kubva kuna amai vavo uye imwe kubva kuna baba vavo. Kune marudzi mazhinji emagetsi eDQ, asi kune maviri ayo anobatanidzwa muhuwandu hwezvirwere zvechiliac: HLA-DQ2 uye HLA-DQ8 .
Pakati peizvi, HLA-DQ2 ndiyo inonyanya kupararira muhuwandu hwevanhu, zvikurukuru pakati pevanhu vane European heritage-vanenge 30% kana kupfuura yevanhu avo madzitateguru avo vakadzingwa kubva kune chikamu chenyika vanotakura HLA-DQ2.
HLA-DQ8 inofungidzirwa isingawanzoviki, inoonekwa inenge 10% yehuwandu hwehuwandu hwevanhu, kunyange ihwo hunozivikanwa zvikuru kuvanhu vanobva kuCentral neSouth America.
Dzidzo dzakaratidza kuti inenge 96 muzana yevanhu vanorwara nehupsy vane chirwere chechiliac inotakura DQ2, DQ8 kana kusanganiswa kwemaviri. Sezvo iwe uwana DQ gene kubva kuna amai vako uye imwe kubva kuna baba vako, zvinokwanisika kuti uve nemakopi maviri eDQ2, makopi maviri eDQ8, kopi imwe yeDQ2 uye imwe yeDQ8, kana imwe kopi yeDQ2 kana DQ8 yakabatana imwe DQ gene.
Chero chiitiko chipi zvacho, kana iwe wakatakura imwe kopi yeDQ2 kana DQ8, iwe unofungidzirwa kuva nehuwandu hwepamusoro hwezvirwere zvechiliac. Pane humwe uchapupu hwokuti kutakura makopi maviri eimwe majini (zvichida DQ2 kana DQ8) inogona kuwedzera dambudziko rako kunyanya.
Kunyanya kuongororwa kumwe kwakaratidza kuti imwe geni chaiyo, HLA-DQ7 , inotungamirirawo vanhu kune chirwere chechiliac. Mukati, mune izvo zvidzidzo, 2 muzana yevanhu vane chirwere chinonzi biopsy-chinoratidzwa neecliac yakatakura HLA-DQ7, asi kwete DQ2 kana DQ8. Zvisinei, pane mhirizhonga pamusoro pokuti kana DQ7 inonyanya kukonzera kuti uwane chirwere chechiliac, uye kuongorora mazita eUnited States hazvizivikanwe DQ7 se "chirwere chechiliac gene".
Mukuwedzera, tsvakurudzo itsva inokuratidza kuti haufaniri kutakura HLA-DQ2 kana HLA-DQ8 kuitira kukudziridza kusagadzikana kwekunyepa kwekubata .
Panogona kunge kune mamwe mazita eHLA-DQ anobatanidzwa muhutano hwe gluten; verenga zvakawanda muUno unoda magweta chaiwo kuti uwedzere kugunun'una kwe gluten?
Celiac Gene Test inosanganisira Screen Yakajeka
Kuongororwa kwechirwere chechiliac mazamu haisi kuparadza zvachose. Iwe unogona kugovera laboratori nemuenzaniso weropa rako, shandisa swab kuti uunganidze mashoma emasero kubva mukati musaya rako, kana shandisa siriniti kana kuti vial kuti uunganidze mamwe emapapiro ako. Ropa rako, masama masero kana salivha zvino zvinongororwa ne laboratori; imwe yenzira idzi inobereka zvakajeka zvakafanana.
Vanhu vazhinji vane zviratidzo zvekuberekwa zvakaitwa pamwe pamwe nezvimwe zviedzo zvakarayirwa nachiremba wavo.
Zvisinei, zvinogona (kunyange zvazvo zvinodhura) kuwana muedzo pasina chiremba achibatanidzwa.
Kune nzvimbo mbiri iwe unogona kuve nokuedzwa kunoitwa pasina urongwa hwechiremba: Enterolab, rimwe laboratory inowanikwa muDallas ( Enterolab inoitawo kuongororwa kwekukudzwa kwe gluten ), uye kuwanikwa kwekuberekwa kwemajini 23andMe.com.
Nekukomberedza $ 150 (yakabhadharwa panguva yaunoisa urongwa), Enterolab achaongorora majeni ako uye akuudzei maitiro aHLA-DQ aunotakura, kusanganisira kana iwe wakatakura chimwe chezvinhu zviviri zvakakosha zvechirwere chetachiona. Muedzo unoitwa nemasero akaunganidzwa neshubhu mukati mebama rako, saka hapana kutevedza kweropa kunobatanidzwa. Kana ukangoputira tsama rako uye chikepe kubva pane samuenzaniso yako, zvigumisiro zvinotumirwa kwauri mukati memavhiki matatu.
Ne 23Me.com, panguva iyoyo, iwe uchapfira mumoto uye utumidze chigadziko kuti uedzwe. Kambani inopa chirwere chechiliac chirwere kuburikidza ne "Health and Ancestry" chisarudzo, icho chinodhura madhora mazana maviri. Mharidzo yako zvakare ichapa ruzivo rwakanyatsonaka pamusoro pemadzitateguru ako, uye nhoroondo pamusoro peiyo genetic hama.
Genetic Testing Haisi Kuenzana Kuongororwa
Sezvo isiri munhu wese anotakura mhepo yemhepo yakawanda inowanikwa nechirwere checliac (vanhu vakawanda havanzwisisi mamiriro ezvinhu kunyange nejeni, chaizvoizvo), chimiro chakanaka chekuberekwa hachikwanisi kuongororwa. (Onai: Ndakaedzwa mukati mangu mucheri wangu.
Zvose rako rakanaka chirwere chechiliac chiedza chinowanikwa iwe pane izvo vanachiremba vanofunga seboka "risina ngozi" rechirwere chechiliac. Nokudaro, chirwere chechiliac chirwere chemajini chinonyanya kubatsira kutonga kunze kwechirwere chechiliac mune zviitiko apo zviratidzo zvechiliac iripo. Mune zvimwe zviitiko, munhu angave akave nemigumisiro yeecliac yechiratidzo isiri pachena-yakatemwa, uye kuongorora kwejena kunogona kubatsira chiremba kuti aongorore zvakakodzera.
Gene kuongororwa zvakare kunobatsira kutonga kunze kwechirwere chechiliac mumhuri yemhuri yeiyiiiiii celiacs. Chirwere cheCeliac kuongororwa nehama chinokurudzirwa kana mumwe munhu mumhuri yako achiongororwa, asi kana iwe uchiziva kuti unotakura chirwere cheliacac gene, unofanira kuteverwa zvakanyanya.
Pakupedzisira, zvinobvira kushandisa kuedza kwejeni kuona kana chirwere chechiliac chikaitika kune mumwe munhu ari kutotora kudya kusina gluten .
Iwe unofanirwa kunge uchidya gluten kuongororwa kwechirwere chechiliac inowanzove yakarurama. Zvisinei, vamwe vanhu vanoziva kuti kudya gluten-kusina kuita kuti vanzwe vari nani, uye bvisa mapuroteni a gluten kubva pane kudya kwavo vasati vasangana nekuedzwa kwechirwere ichi. Kana mushure mekunge vachisarudza kuti vanoda kuongororwa, vane zvisarudzo zviviri: kuedza dambudziko re gluten , kana kuti vanoedza kuongororwa kwemajini.
Iwe haufaniri kunge uri kudya gluten kune chirwere chechiliac chirwere-zvakare, muedzo unongoronga chete kana iwe unogona kukudziridza chirwere ichi, kwete kana iwe uine. Nokudaro, kunyange zvazvo mazita ekuedza maitiro asingakwanisi kupa mhinduro dzakakwana pamusoro pekuti iwe unotova nechirwere cheecliac, vanhu vakawanda vanochifarira kuva dambudziko re gluten nokuti hazvidi kuti vadzoke zvakare pane gluten kuti vawane mamwe mashoko pamusoro pemamiriro avo.
Pane zvakawanda zvatisati taziva pamusoro pezvirwere zvechiliac, uye hazvisi pachena kuti nei vamwe vanhu vane chirwere chechiliac vachikudziridza asi vamwe vasingaiti. Zvisinei, chirwere chechiliac chirwere chekuberekwa chinogona kubatsira kuongorora njodzi yemamiriro ezvinhu mumhuri, uye mumamiriro ezvinhu asina kunyatsojeka-akacheka.
Sources:
Celiac Disease Center ku Columbia University. Serologic uye Genetic Testing. Yakasvika muna Jan. 5, 2012.
National Institutes of Health. NIH Conform Development Conference pamusoro peCeliac Disease. Yakasvika muna Jan. 5, 2012.
Sacchetti L. et al. Kusarura pakati peCeliac uye Zvimwe Zvekugadzikana Kwemakumbo muhuduku neRupid Human Lymphocyte Antigen Typing. Clinical Chemistry. Aug. 1998, Vol. 44, Nha. 8, p. 1755-1757.
University of Chicago Celiac Disease Center. Genetic Testing . Yakasvika muna Jan. 5, 2012 ..