Mimwe yemishonga yauri kutora kune zvimwe zvirwere, zvakadai sekumusoro kwehutano weropa kana kuti zvirwere zvehomoni - zvinogona kukuvadza hutachiona hwehutachiona. Izvi zvinogona kusanganisira kuwedzera yako LDL uye triglyceride levels kana kuderedza yako HDL cholesterol. Izvi zvinogona kuva zvinotambudza kana iwe usati wambototanga kunetseka pamusoro peholesterol yakakura kare. Uyezve, kana iwe uri mishonga yekuderedza cholesterol yako, ungaona kuti kurapa kwako kunogona kuchinjwa.
Kunyangwe ichi hachisi urongwa hunosanganisa, mishonga inorongwa pasi apa ndiyo inowanzoshandiswa mishonga inogona kuchinja mazinga ako echidimbu. Iwe unofanirwa kuzivisa nguva dzose kune wako wehutano wehutano mishonga yauri kutora, saka iye anogona kutonga kunze kana pasina mishonga kana zvigadzirwa zvepanyika zvinokanganisa utano hwako:
Prednisone
Prednisone glucocorticoid iyo inoshandiswa kuderedza kusuruvara, shungu, uye unyoro zvinosangana nemamiriro akawanda ekuputika. Pasinei nokuzorodzwa kwavanogona kukupa, vanogona kusimudza triglycerides, LDL cholesterol mazinga, uye HDL cholesterol mazinga. Hazvisi kutora kwenguva yakareba kuona kuwedzera kwakanyanya kwehushutoriol: Dzimwe tsvakurudzo dzakaratidza kuti varwere vaiva nehuwandu hwecholesterol mukati memavhiki maviri ekurapa.
Beta Blockers
Beta blockers mishonga inowanzogadziriswa kurapa kukwirira kweropa. Pasinei nezvipo zvinokosha, vanopa mukurapa maitiro akasiyana ezvirwere zvepfungwa, beta blockers zvakare akaonekwa kuti anoderedza mazinga eHDL uye anokwidziridza hutachiona hwemarglyceride.
Muzviitiko zvakawanda, zvisinei, kuchinja kwepachiviriro kwave kwakanyanya kuduku. Zvakakosha kuziva kuti havasi vose beta blockers vane izvi. Izvozvo zvinotevera beta-blockers zvakaonekwa kuti zvichishandura zvinyorwa zvepidid:
- Atenolol (Tenormin®)
- Bisoprolol (Zebeta®)
- Metoprolol (Toprol®, Lopressor®)
- Nadolol (Corgard ®)
- Propanolol (Inderal ®)
Beta-blockers havangobatsiri kuderedza kuwedzera kweropa, ivo vanobatsirawo kuwedzera kupona kwevanhu vane chirwere chemwoyo chinoshingaira (zvakadai sokupererwa kwemwoyo mwoyo uye kusangana kwemoyo kare). Saka, kunyange kana kushanduka kuduku kwezamu yako kuchicherechedza, zvakakosha kuti beta blockers haisi kurega.
Amiodarone
Amiodarone imishonga inoshandiswa kurapa maitiro akasiyana-siyana emukati uye inosanganiswa nemhando dzakawanda dzemigumisiro. Chimwe chezvikamu zviduku zvinokonzerwa nehoteestol yakakwirira . Amiodarone inonyanya kukwidza LDL cholesterol maitiro asi haisi kuve neine simba kune HDL cholesterol kana kuti triglyceride mazinga.
Estrogen
Estrogen inhengo yevakadzi inokonzerwa nekodhi inowanikwa mumadzimai ekuberekwa kwehomoni uye mune mamwe maitiro ehomoni inotsiviwa. Kwemakore mazhinji, estrogen yakanga yave ichinzi "chirwere chekuvadza," nekusimudzira mwoyo wakachena . Izvi zvinonyanya kukosha nekukwanisa kwayo kukwidziridza mazinga eHDL. Izvi zvakakonzera vakadzi vazhinji vanotevera-menopausal vachitora hormone replacement therapy kuti vabatsire mwoyo yavo. Zvisinei, zvidzidzo zvenguva pfupi zvakawana kuti hazvidziviriri kurwisa chirwere chemwoyo mushure mokunge apera. Iyo nzira iyo inokonzera kusangana kwemwoyo isingazikamwi.
Uyezve, isrogens inogonawo kuwedzera triglyceride mazinga.
Progestin
Progestin inzira yeprogesterone, imwe mukadzi weshure hormone, iyo inoshandiswa mumuromo wekudzivirira pamuviri uye hormone replacement therapy chete kana inosanganiswa ne estrogen. Nhamba dzakakwirira dze progestin dzave dzichibatanidzwa nechepasi peHDL levels. Mukubatana ne estrogen, progestin inogona kubvisa mararamiro ane utano estrogen inokura HDL mazinga.
Anabolic Steroids
Anabolic steroids inosanganisira testosterone, mukono weshurume wekono unoshandiswa kurapa kunonoka kwezera muvakomana uye mamwe maitiro ekushaya simba. Inoshandiswa zvakare kusina mvumo yekuvaka musimba mashoma.
Iyi mishonga inosimudza mazinga eLDL uye inowedzera maCDL. Zvinokanganisa zvinokonzerwa nemishonga iyi kune cholesterol mazinga anowanikwa zvakajeka mumuromo wemishonga pakuenzanisa nemishonga inoshandiswa.
Cyclosporine
Cyclosporine (Sandimmune ®, Neoral®, Gengraf®) chirwere chinoshandiswa kupedza masimba ezvirwere. Inowanzoshandiswa mushure mekugadzirwa kwechirongwa kuitira kudzivisa kurambwa. Zvisinei, inogona kushandiswawo kubata rheumatoid arthritis uye psoriasis. Dzidzo dzakaratidza kuti cyclosporine inomutsa LDL cholesterol mazinga.
Protease Inhibitors
Protease inhibitors inoshandiswa kurapa hutachiona hwehutachiona hwe HIV (HIV). Kunyange zvazvo mishonga iyo mishonga iyi inokwidza cholesterol maitiro isingazikamwi, inowanzoita kuti iwedzere huwandu hwemarglyceride uye huwandu hweHDL cholesterol. Fibrate uye zvigaro dzimwe nguva zvinoshandiswa kuderedza triglycerides uye kuwedzera huwandu hweHDL mumunhu anotora mishonga iyi.
Diuretics
Diuretics inoshandiswa kuporesa kukwirira kweropa uye kuchengetedza mvura. Kune marudzi maviri e diuretics anokonzera kuwedzerwa kwehushutoriki:
- Thiazide diuretics (kusanganisira hydrochlorothiazide, chlorothiazide, metolazone)
- Loop diuretics (kusanganisira furosemide, torsemide, bumetanide)
Thiazide diuretics inokonzera kuwedzera kwenguva pfupi muoklesterol yose, mazinga e triglyceride, uye LDL cholesterol mazinga. HDL yeCholesterol mazinga haawanzobatwa. Iko kukura kunogona kutarisa pakati pemamiriyoni mashanu kusvika ku10 pa deciliter. Pari zvino, indapamide ndiyo chete thiazide diuretic iyo isina kuratidzirwa kuti inogona kukanganisa mazinga. Loop diuretics inoshandisa muenzaniso wakafanana neye thiazide diuretics; zvisinei, mamwe emishonga iyi akaratidza kuderera kuduku muHDL cholesterol. Sezvo diuretics yakakosha zvikuru mukurapa kwekuderedza ropa, mutapi wako wehutano anogonawo kukuisa pane zvokudya zvakaderera-mafuta paunenge uri pamushonga uyu.
Kana uine cholesterol yakakura uye uri kutora mishonga inogona kukwanisa kukwidziridza zvirwere zvako zvinowedzera, mutapi wako wehutano angada kuongorora ropa rako nguva nenguva kuti ave nechokwadi chekuti mapidhi ako haasi akakwirira. Mune zvimwe zviitiko, kukanganisa kwakaipa pa lipids kunogona kuva kwenguva pfupi. Zvisinei, kana vakaramba vachikwirira mushure mekunge mushonga watanga, mutapi wehutano wako angasarudza kuwedzera kana kugadzirisa cholesterol-kuderedza chirwere.
Sources:
Dipiro JT, Talbert RL. Pharmacotherapy: A Pathophysiological Approach, 9th, 2014.
> Gwaro Rechitatu reNational Cholesterol Education Program (NCEP) Gweta reVadzidzisi paKutsvaga, Kuongorora, uye Kuchengetedzwa kweHurumende yeHood Cholesterol muVakuru (PDF), July 2004, National Institutes of Health: The National Heart, Lung, uye Blood Institute.
Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. Http://www.micromedexsolutions.com.