Nicotine inokonzera chirwere kana kukonzera kenza mhiri kupararira here? Nicotin inobatsira sei pamishonga yekenza? Sezvo vazhinji uye vakawanda vachirega kusvuta zvinodhaka zvine nicotine zviripo, izvi zvinowedzera mibvunzo inokosha. Pane imwe nhema dzinonyanya kubatsirwe nicotine kubatsiridza-therapy-inogona kubatsira vanhu kukanda tsika inozivikanwa kuti inokonzera kenza (nezvimwe zvirwere zvizhinji.) Kune rimwezve zvakanyanya ndevamwe vanhu vanotaura kuti nicotine inogona kuuraya uye yakatoshandiswa pakutanga semushonga.
Migumisiro yeNikotini paCancer
Kuti tipindure mubvunzo uyu-basa reicicinine pamusoro pekenza-mubvunzo unofanirwa kuputsika muzvikamu zvakasiyana. Sezvo zvakadaro, tinofanira kuongorora basa reicicin inotevera:
- Kumhanyira Kutanga kana Mutagenicity - Izvi zvinoreva kukwanisa kwezvinhu zvinokonzera kukanganisa (kushanduka kweDNA) kunofanirwa kushandura sero rinowanzova mune kenza yekenza .
- Tumor Promotion / Tumor Progression - Izvi zvinoreva kukwanisa kwechimwe chinhu kuita kuti tumarara inenge yavapo kuti ikure nokukurumidza uye / kana kupararira (metastasize) kune dzimwe nzvimbo dzomuviri nokukurumidza.
- Migumisiro yechirwere chekenza - Izvi zvinoreva kuitika kwezvinhu zvinogona kuve nokurapa kenza, somuenzaniso, kana chinhu chinodzivisa kana kudzivirira chiito chemhemotherapy mishonga.
Basa Rinoitwa Nicotine Inotamba muCancer
Kunyange zvazvo zvidzidzo zvisati zvamboitwa pamigumisiro yese inokonzera nicotine pamarariya ose. Uye, dzakawanda zvekudzidza kusvika nhasi zvakagadzirwa pamakonzo, makonzo, kana pamasero emakemikari akakurira mubasa, tinoziva zvinotevera:
- Migumisiro yeNikotini Pamusana Pamuviri Kutanga kana Mutagenicity - Zvidzidzo zvenguva pfupi zvakaratidza kuti nicotine ine mabasa emuviri uye zvinokurudzira matumbo. Panewo humwe uchapupu hwokuti nicotine inogona kukonzera DNA kukuvadza-rudzi rwekukuvadza kunogona kukonzera kenza. Panewo uchapupu hwokuti nicotine inotanga chirongwa checarcinogenesis-zvinoreva kuti kushandiswa kwesero kuve nekenza mune chimwe chinhu kunowedzera. Izvi hazvireve kuti hazvisi ngozi kune avo vasina kenza. Migumisiro iri pasi inogona kuitika kana kenza iripo asi ichigere kuonekwa.
- Migumisiro Pamusana Pakukudziridza uye Kubudirira - Kunyange zvazvo nicotine isingave iri iyo inokonzera masero okutanga ari mumaronda achiva nekenza, zvidzidzo zvakawanda zvekare zvakaratidza kuti kana imwe kenza inowedzera, nicotine inogona kukurudzira kukura kwemarara. Semuenzaniso, nicotine yakawanikwa ichikurudzira kushungurudzika kwekenza yepancreatic mumakonzo. Yakave iwanikwewo kukurudzira kupararira, kupindira, uye kubuda kwemarara mumasero muchechi asiri maduku emukenza wemapapu.
- Migumisiro Yezvipinduri Kurapa Kurapa - Nicotine yakawanikwa ichivhiringidza kune zvimwe zverapa yekenza, izvo zvinogona kureva kuti nicotine inogona kuderedza kuponeswa kwemaronda kubva pamukenza. Somuenzaniso, nicotine inogona kukurudzira kupikisa chemotherapy drug Platinol (cisplatin) mumasero emukenza emapapu.
Zvakakosha kucherechedza kuti, mune dzakawanda zvezviongorori izvi, nicotine inoongororwa zvakasiyana neyekuputa fodya kuitira kuti ave nechokwadi chokuti zvinokonzerwa neicotine pachako pane pane zvimwe zvinhu zviripo mune fodya.
Iyo Nicotine Inoshanda Sei Kukurudzira Kanzera Kukura nekupararira nekuderedza kubudirira kweUrapa
Kune nzira dzakawanda dzakasiyana-siyana iyo nicotine yakawanikwa inogadzirisa kukura nekupararira kwekenza.
Izvi zvinosanganisira:
- Kuvandudza kutanga kwekenza (sezvakataurwa pamusoro apa).
- Kukurudzira tumor kukura (kuburikidza nekukurudzira mapuroteni anokonzera kupatsanurwa kwesero nekukura).
- Kukurudzira kenza kunopararira (somuenzaniso, kuburikidza nekuvandudza kushandiswa kwemasero emukenza (sezvataurwa pasi apa).
- Kuvandudza angiogenesis - Nicotine inogona kuwedzera kukwanisa kwekenza kubudisa mishonga yeropa itsva inoda kukura uye kudzivirira kufa kwechisikwa kwemasero anenge akwegura kana asina kujairika (apoptosis.)
- Zvinokonzera kushungurudza chemiresres - kuburikidza nekukurudzira nzira dzakasiyana-siyana, nicotine inogona kuita kuti mutezo usanyanya kunyatsoziva chemotherapy agents.
Kunyangwe kutsanangura nzira dzakanyatsogadziriswa zvakanyanyisa uye zvisingasviki pakukura kwechinyorwa chino, mienzaniso shomanana yenzira iyo nicotine yakawanikwa kukurudzira kukura nekupararira kwekenza kunosanganisira:
- Nicotine inogona kushanda nekusunga nematafura anonzi nicotinic acetylcholine receptors (nAChRs.) Zvechokwadi, iyi ndiyo nzira iyo nicotine inodhaka. Nokuita izvi zvinogamuchirwa nicotine zvinogona kukurudzira kukura kwemakumbo, kukurudzira kuumbwa kwemitsipa yeropa itsva inodiwa kuti kanzira ikure ( angiogenesis ) uye inodzivisa kufa (apoptosis) yekenza masero. Kubva pane kune kusiyana kwe nicotinic acetylcholine receptors pakati pevanhu vakasiyana, izvi zvinogonawo kuchinja pakati pevanhu vakasiyana. (Zvinonakidza, kuti nicotine yakanyanya kukanganisa inokonzerwa nehuwandu hwemukenza wemapapu.)
- Nicotine inosimudzira puroteni inozivikanwa se beta-arrestin-1. Iyi proteiniti, inobatsirawo, inowedzera kufamba kwemamwe mapepa emapapu emapapu achivabvumira kuti vapararire uye vapinde nyore nyore.
Cancers Inobatanidzwa KuNikotini mune imwe nzira
Izvo zvinokonzera nicotine pakuvamba, kufambira mberi, uye kupindura kurapwa hazvina kuongororwa kumarariya ose, asi kune uchapupu hwokuti nicotine inogona kuita zvinokuvadza munzira imwe chete yeiyi yerukari inotevera:
- Mukomana muduku wekenza yemapapu
- Chero-duku kenza yemukenza yemapapu
- Musoro nemutsipa makondombera
- Chirwere chepamuviri (kenza yemuviri)
- Kenza yepancreatic
- Gallbladder kanzera
- Chirwere cheropa
- Kanononi yeColon
- Kansa yepabonde
- Chirwere chemukomuzha
- Chirwere chechirwere
- Mukenza wepoyo (mutsara wesero renal)
Sources:
Catassi, A. et al. Nhamba dzakawanda dze nicotine pamasero ekuwedzera uye kusadzivirira apoptosis: zvinoreva pamapapu carcinogenesis. Mutation Research . 2008. 659 (3): 221-31.
Dasqupta, P. et al. ARRB1-murairidzi wehutano hweE2F hunotarisa majeni mu nicotine-inoita kukura kwemamapu emapapu. Zvinyorwa zveNational Cancer Institute . 2011. 103 (4): 317-33.
Dinicola, S. et al. Nicotine inowedzera kupona mumasero ekenza evanhu anobatwa nekemotherapeutic zvinodhaka. Toxicology In Vitro . 2013. 27 (8): 2256-63.
Gemenetzidis, E. et al. FOXM1 Kukwidziridzwa Ndiyo Chiitiko Chekutanga Mudare Revanhu Rinosemesa Carcinoma uye RINOsimbiswa neNicotine munguva yeMalignant Transformation. PLOS One . Yakabudiswa March 16, 2009.
Grando, S. Kubatana kwekicinine kune kenza. Nature Reviews. Cancer . 2014. 14 (6): 419-29.
Grozio, A. et al. Nicotine, mapapu nemukenza. Anticancer Agents muMedicine Chemistry . 2007. 7 (4): 461-6.
Guha, P., et al. Nicotine inokurudzira apoptosis kusagadzikana kwemasero epabonde emvere uye kuwedzerwa kwemasero evanhu vanoverengeka vane kenza stem-sezvivako zvakadai kuburikidza nechiratidzo chekudzivirira chinosanganisira galectin-3, a9 nicotinic acetylcholine receptor uye STAT3. Chirwere Chepabonde Research and Treatment . 2014. 145 (1): 5-22.
Hermann, P., et al. Nicotine Inokurudzira Kutangira uye Kuwedzera kweKRAS-Induced Pancreatic Cancer kuburikidza neGata6-Dedifferentiation yeAcinar Cells muMice. Gastroenterology . 2014. 147 (5): 1119-1133.
Medjber, K. et al. Basa re nicotinic acetylcholine receptors mu cell proliferation uye chirwere chinopinda mu bronch0-pulmonary carcinomas. Lung Cancer . 2015 Jan 15. (Epub mberi kwekudhinda).
Nair, S., Bora-Singhal, N., Perumal, D., uye S. Chellappan. Kurwisa kweNikotini-kupindirana uye kutama kwemasero mashoma emapapu memascitoma nekugadzirisa zvirwere zve STMN3 neGSPT1 nenzira yakatarisana neDI1. Molecular Cancer . 2014. 13: 173.
Nishioka, T., et al. Sensitization ye epithelial kukura kwezvinhu zvakagadziriswa neicotine kuwedzerwa kukurudzira kenza yemazamu kukura. Chirwere Chepabvu Ongororo > 2011. 13 (6): R113.
Petros, W., Younis, I., Ford, J., uye S. Weed. Migumisiro yekutsvuta fodya uye nicotine pamakirini ekurapa. Pharmacotherapy . 2012. 32 (10): 920-31.
Pillall, S. et al. B-arrestin-1 anopindira nicotin-induced metastasis kuburikidza neE2F1 chinangwa chemasvikiro anogadzirisa epithelial-mesenchymal shanduko. Cancer Research . Yakabudiswa paIndaneti Chekutanga January 19, 2015.
Printz, C. Yakasimba nicotine inodhaka yekubatwa nehuwandu hwemapapu emapapu. Cancer . 2014. 120 (23): 391.
Schaal, C., uye S. Chellappan. Nicotine-mediated cell proliferation uye kufambira mberi kwechirwere mumakemikari anokonzera kusvuta. Molecular Cancer Research . 2014. 12 (1): 14-23.