Angiogenesis uye Inhibitors muCcercer Treatment
Tsanangudzo: Angiogenesis
Angiogenesis inoreva kuumbwa kwemidziyo yeropa mumutumbi. Iro chirongwa chemuviri chepanyama chekuporesa asiwo chinotora basa mukukura kwekenza.
Angiogenesis mu Health uye Healing
Angiogenesis inzira inowanzoitika mumutumbi mune chero mamiriro ezvinhu umo kukura kwemidziyo yeropa inoshandiswa.
Sezvo zvakadaro, zvakakosha kuti vana vakure, nokuti uterine mbatya kukura mwedzi mumwe nomumwe mumadzimai e-premenopausal, uye nemaronda kuti apore.
Angiogenesis muCancer uye Metastasis
Angiogenesis inofarira mukenza nokuti mishonga inoda kuti kuumbwa kwemidziyo mutsva yeropa kuwedzere uye kukura. Kuti zvirwere zvekenza zvikure uye zvive zvakakura kupfuura imwe mamita (1 mm) angiogenesis inofanira kuitika. Cancers anoita izvi nokuvhara zvinhu zvinokurudzira angiogenesis, uye naizvozvo, kukura kwekenza.
Mukuwedzera pakuva chirongwa chinodiwa chekenza kuti ikure uye inopinda muvakidzani mechipoteredza, zvinokosha kuti metastasis iite . Kuti zvirwere zvekenza zvifambe uye dzigadzirire musha mutsva pane imwe nzvimbo kunze kwekubva kwadzo, masero aya anoda kuunza mitsva yeropa itsva mukutsigira kukura munzvimbo dzavo idzva.
Angiogenesis uye Vascular Endothelial Growth Factor (VEGF)
Mishonga yeropa inoumbwa nemasero anonzi endothelial cells mukati memidziyo.
Zvimwe zvinozivikanwa sevascular endothelial kukura zvinhu, VEGF kwenguva pfupi, zvinoshanda sezviratidzo zvinoita kuti magetsi endothelial akure uye agadzire misha midzi yeropa. Mune mamwe mazwi, ivo vashanduri. Ropa mudziyo wakaumbwa mumuviri, semabasa akawanda, ndeyekuyera kwekuita uye kuvhara migumisiro.
Angiogenesis Inhibitors
Angiogenesis inhibitors vane maitiro ezvokurapa , izvo zvinoreva kuti vanonyatsotarisa masero emukenza kana masero anodiwa pakukura kana kupararira kwekenza.
Iyi mishonga inogona kukanganisa kushandiswa kwemangiogenesis pamatunhu akasiyana-siyana. Zvimwe zvezvinhu izvi zvinorambidzwa nekusunga kumapapiro ekupedzisira ekukura (VEGF) kuitira kuti irege kugona kuratidza kuti endothelial cells dzinokura, uye saka dzinomisa kuumbwa kwemidziyo mitsva yeropa.
Mienzaniso yeAngiogenesis Inhibitors
Dzimwe angiogenesis inhibitors izvo zvino zviripo pakurapa kenza dzinosanganisira:
- Avastin (bevacizumab)
- Nexavar (sorafenib)
- Sutent (sunitinib)
- Vavengi (pazopanib)
- Afinitor (everolimus)
Dzidza zvakawanda pamusoro pekudzivirira muviri uye kuti angiogenesis inhibitors inoshanda sei kubata chirwere.
Angiogenesis Inhibitors Plus Chemotherapy
Mubvunzo wakawanda ndewokuti vanhu vangada chemotherapi kunze kweangiogenesis inhibitors. Kutarisa nzira iyo angiogenesis inhibitors inoshanda inobatsira kutsanangura izvi. Angiogenesis inhibitors haiti kuuraya kanzira, vanongoshanda kuti vadzivirire kukura nekukura (metastasizing), saka kuitira kuti vabvise chirwere, chemotherapy inofanira kushandiswa pamwe chete neangiogenesis inhibitors.
Migumisiro Yechechi yeAngiogenesis Inhibitors
Apo angiogenesis inhibitors yakatanga kuwanikwa sekurapa kwekenza, vaifungidzirwa kuti vaizova nemigumisiro shoma.
Izvozvo zvakanga zvisina kudaro. Kungofanana nekemotherapy inokonzera migumisiro yemaitiro nezviito zvayo pamasero mashoma (somuenzaniso, nekumira kusabatanidzwa kwemasero mumapfupa emvere, mapfupa emapfupa, uye maitiro emuviri) angiogenesis inhibitorswo zvinogona kukonzera migumisiro yechiratidzo maererano nemabasa avo mumasero ane utano nemaviri. Zvimwe zvinowanzovhiringidza zvinokonzerwa ne:
- Kurapa kwakakuvara kurapwa kubva kune angiogenesis inhibitors hakungopindi kukanganisa nekwaniso yemasero ekenza kuita mishonga yeropa idzva asiwo inopindira nekwanisi yemasikirwo akachengetedza kuita mishonga yeropa idzodzo kutsiva kukuvara.
- Kuvhara mumatricu, izvo zvinogona kutungamirira kumarwadzo emoyo nekurova.
- High blood pressure.
The Future / Clinical Trials
Mishonga yakawanda iri muchikwata ichi iri kuongororwa mumakiriniki, uye kune tariro yokuti kurwisa kenza pamusana pekupindira neangiogenesis ichava chikamu chemamwe mararamiro ekurapa kenza munguva yemberi.
Sources:
American Society of Clinical Oncology. Cancer.Net. Angiogenesis uye Angiogenesis Inhibitors Kurapa Kanza. 07/2014. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer
National Cancer Institute. Angiogenesis Inhibitors. Updated 10/07/11. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet