Pane chekubatana pakati pemukenza weserogen uye mapapu here? Tinoziva kuti kune kusiyana kukuru pakati pemukenza wemapapu muvakadzi nekenza yemapapu mune varume. Isuwo tinoziva kuti masero emukenza emapapu ane estergen receptors, ndiko kuti, nzvimbo dziri pamusoro penhare iyo inogona kusunga neserogen. Kunyange zvazvo ruzivo rwedu rusingakwanisi kupera panguva ino, izvi zvinorevei kune vakadzi vane kenza yemapapu nhasi, kana kuti pangozi yemukenza wemapapu munguva yemberi?
Usati wataura pamusoro pezvidzidzo, zvinobatsira kutsanangura kuti sei zvimwe zvingaguma zvingave zvakavhiringidza zvikuru. Pano pane dzimwe nzira dzakasiyana-siyana (nzira) iyo isrogen inobatsira mukenza yemapapu. Zvakakoshawo kuratidza kuti vazhinji vezviongorori izvi varikutaura nezvezvinhu zviviri zvakasiyana kwazvo. Chimwe chinhu chinokonzera-ingave yepamusoro kana yepamusoro yeestrogen ine simba kune mumwe munhu angava nekenza yemapapu pakutanga? Icho chimwe chiri kufambira mberi-ingava isrogen inokonzera kenza yemapapu inenge yavapo iko kukura nokukurumidza kana kuti inonoka?
History Reproductive
Kunyangwe tichiziva kuti kenza yemazamu inowanzoonekwa kune vakadzi vanotanga kuva nenguva panguva duku, zvidzidzo hazviwani kuti izvi ndizvo zvinoitika nekenza yemapapu. Kanzera yemaperembudzi yaifungidzirwa kuti haina kunyanya kuonekwa kune vakadzi vakambova nevana vakawanda kupinda kune avo vakave nevana vashomanana kana zvachose, kunyanya kuvakadzi vasina kumbosvuta.
Chimwe chiitiko chekuongorora chekuongorora kusvika nhasi chinoratidzira kuti kwete chemadiki chekenza yemapapu emapapu , asi kwete chekenza yemukenza yemapapu , inogona kunge isina kunyanya kufanana kune vakadzi vane vana vakawanda. Chimwe chidzidzo chakawana kuti, kusiyana nekenza yemazamu, kenza yemukenza yemapapu yaiva shoma apo vakadzi vakaberekwa pane imwe nguva yemakore.
(Mukuenzanidza, nekenza yepazamu ingozi inoderedzwa nokuva nemwana wekutanga muhupenyu (asati asvika 30) asi ngozi yekenza yemapapu inopera zvishoma nekuva nemwana gare gare muupenyu.)
Kuongororwa kwemazuva ano kunoratidza kuti vakadzi vane mazai avo maviri mavari ("chirwere chokuvhiya") inogona kuva nenjodzi yakakwirira yokuva nekenza yemapapu. Zvimwe zvidzidzo zvakare zvakaratidza kuwirirana kuduku pakati pekuenda kumwedzi nekutanga kwekenza yemapapu.
Animal Studies
Chimwe chekudzidza pamakonzo chakataura kuti estrogen inogona kukurudzira kukura kwekenza yemukenza. Muchidzidzo ichocho, mbeve dzevakadzi dzakange dzine mazai dzakawedzera mapfupa emapapu akawanda kupfuura mhuru dzevakadzi dzaive dzakabviswa mazai avo. Mukuwedzera, apo mhete dzisina mazai dzakarapwa ne estrogen, mvere dzavo dzakakura nokukurumidza kupfuura mhando dzisina kubatwa ne estrogen.
Hormone Replacement Therapy
Kusanganiswa kweHonmone replacement therapy , kana kuti HRT (estrogen uye progesterone) nokuda kwechiratidzo chemarumeopausal inogona kuwedzera kungozi yekufa nemukenza wemapapu, kunyanya kune vanhu vanosvuta. Muchidzidzo chevakadzi vane zviuru zvitanhatu nevana vasati vashoma kanzera yemapapu emapapu, avo avo vaishandisa kusanganiswa kwehomoni inotsiviwa nehutachiona vaiva 60 muzana yehuwandu hwekufa nehosha. Zvakakosha kuziva kuti muchidzidzo ichi, kusangana kweHRT kwakakonzera njodzi yekufa kubva pamukenza wemapapu kana vakatova nayo, asi kwete mukana wokuti mumwe munhu ave nekenza yemapapu.
Kakawanda, zvidzidzo zvakatarisa kuenzaniswa sechikonzero chekenza yemapapu zvakasanganiswa, nezvimwe zvichiratidza kuwedzera, zvimwe zvisingaratidzi kushamwaridzana, uye zvimwe zvidzidzo zvitsva zvinoratidza kuderera kwechirwere chemapapu emapapu.
A Recent PLoS review yakarisa basa reestrogen therapy (pasina progesterone) chete pangozi yekenza yemapapu muvakadzi sechikamu cheCalifornia Teachers kudzidza. Muchidzidzo ichi, pakanga pasina kushamwaridzana (hapana kuwedzera kana kuderera) pakati pekushandiswa kwemajoini ekubatanidza (estrogen plus progesterone) uye ngozi yekenza yemapapu. Zvisinei, kune vakadzi vakashandisa isrogen therapy chete, avo vekare vashandisi veestrogen vane nguva shomanana yekushandiswa (pasi pemakore mashanu) vaiva nehuwandu hwekufa nemukenza wemapapu (46 muzana shoma), uye vashandisi vepanguva yeestrogen vane nguva yakareba nguva yekushandiswa (yakapfuura makore gumi nemashanu) yakavewo nehuwandu hwekufa nechirwere (40 muzana zvishoma).
Chimwe chidzidzo chakawana mucheche wemapapu mudiki pakati pevakadzi vakanga vashandisa mapiritsi emishonga ekurapa.
Phytoestrogens
Kudya kwesrogen-based estrogen (phytoestrogens), yakadai seye inowanikwa mu soy, yakatariswa mune zvidzidzo zvishomanana nemukenza wemapapu. Mune zvimwe zveizvi, zvakaonekwa kuti vakadzi vanodya kudya kwakanyanya mu phytoestrogens vane kamuviri kemukenza wemapapu, zvikurukuru pakati pevakadzi vasina kumboputa.
Pasi Pasi
Sezvo mutachiona wemapapu, nenzira dzakawanda, chirwere chakasiyana nevakadzi, zvinokosha kutarisa zvinogona kuitwa zve estrogen. Asi sezvakataurwa pamusoro apa, zvatinonzwisisa nezvekenza yeserogen uye mapapu zvichiri mumakore ekutanga.
Nechinangwa chipi nechipi kana mishonga, zvakakosha zvikuru kuongorora zvikwerero zvekurapa zvinopesana nezviitiko zvinogona kuitika. Somuenzaniso, kana chiremba wako akakurudzira kuti iwe uine mazai ako akabviswa nokuda kwechimwe chikonzero, kubatsirwa kwemuitiro wacho kungave kwakanyanya kudarika kukura kunogona kuitika mumukana wekenza yemapapu.
Nokuti ikozvino, zvidzidzo izvi zvakanaka kukuyeuchidza kutaura nechiremba wako kana uri pane hormone replacement therapy, zvikurukuru kana iwe utsi, uye kubvunza mibvunzo. Iwe unoda kutora mishonga here? Pane imwe nzira here? Pane zvikomborero zvinopfuura kudarika ngozi inogona kuitika yekufa kwepamusoro kubva pamukenza wemapapu (kana kenza yemazamu) here?
Pamusoro pekupedzisira, kunzwisisa kuti masero emapapu emapapu ane eestrogen receptor inozarura mikova iyo zvichida imwe yemishonga inoshandiswa kare kare nokuda kwekenza yemazamu inogona kuita basa mukurapa kenza yemapapu mune ramangwana.
Sources:
Chlebowski, R. et al. Chirwere Chechirwere Pakati Pevanhu VaMenopopaopausal Vanotarisana neEstrogen Chete muHome's Health Initiative Randomized Trial. Zvinyorwa zveNational Cancer Institute . 2010 Aug 13 (Epub mberi kwechinyorwa).
Chlebowski, R. et al. Estrogen pamwe nemukenza wepresinin uye mapapu mumadzimai emasopaopausal (Women's Health Initiative muedzo): kuongorora kwemashure kwekuongorora kwakaitwa randomized. Lancet . 2009. 374 (9697): 1243-51.
Clague, J., Reynolds, P., Henderson, K. et al. Menopausal Hormone Therapy uye Chirwere cheKenza-Inonyanya Kufa Kuchitevera Kuziva: The California Teachers Study. 2014. doi.org/10.1371/journal.pone.0103735.
Hammoud, Z. et al. Estrogen inokurudzira kufambira mberi kwechirwere muine genetically inotsanangurwa mhando yemapapu adenocarcinoma. Kanzerano Inoenderana neCidocrine . 2008. 15 (2): 475-83.
Koushik, A. et al. Zviratidzo zvekuenda kumwedzi uye pamuviri uye njodzi yemukenza wemapapu muvakadzi. International Journal of Cancer . 2009. 125 (10): 2428-33.
Meinhold, C. et al. Kubereka uye hutoni zvinhu uye njodzi yemusana wemukenza wemapapu emapapu. International Journal of Cancer . 2011. 128 (6): 1404-13.
Pesatori, A. et al. Kushandiswa kweHormone uye mungozi wekenza yemapapu: kuongororwa kwakaitwa kubva kune International Lung Cancer Consortium (ILCCO). British Journal of Cancer . 2013 Sep 3. (Epub mberi kwekudhinda).
Pesatori, A. et al. Kubereka uye hutoni zvinhu uye njodzi yemukenza wemapapu: EAGLE Chidzidzo. International Journal of Cancer . 2012 Nov 6. (Epub mberi kwekudhinda).
Rodriquez, C. et al. Postmenopausal hormone therapy uye mutsa wemapapu wemapapu muchechi yekudzivirira chirwere chechipiri II nutrition cohort. Cancer Epidemiology Biomarkers uye Kudzivirira . 2008. 17 (3): 655-60.
Seow, A. et al. Zvimwe zvinokonzera kubereka, kudya kweyerosi, uye kenza yemukenza yemapapu pakati pevakadzi vasina kufanira muSingapore Chinese Health Study. Cancer Epidemiology Biomarkers uye Kudzivirira . 2009. 18 (3): 821-7.
Shimazu, T. et al. Isoflavone kudya uye mungozi wekenza yemapapu: anotarisira boka rekuJapan. American Journal of Clinical Nutrition . 2010. 91 (3): 722-8.
Siegfried, J. Kubva kuchinja kwemazwi emapurmoni kuratidza kufanana kwefodya kunojekesa basa reestrogen metabolism mu lung lung carcinogenesis. Cancer Prevention Research (Philadelphia, Pa) . 2010. 3 (6): 692-5.
Slatore, C. et al. Kenza yemapapiro uye hormone kudzokera kunorapwa: kusangana muvhithamini nekudzidza mararamiro. Nyaya yeCliniki Oncology . 2010. 28 (9): 1540-6.
Yao, Y. et al. IHormone replacement therapy in vakadzi inogona kuderedza dambudziko rekenza yemapapu: meta-analysis. PLoS One . 2013. 14 (8): e71236.