Zvakaita Tsvakurudzo
Amitriptyline inoratidzirwa nehutachiona hwehutachiona iyo inowanikwa chete muhuwandu hwemagetsi muUnited States Yaiwanzotengeswa pasi pezita rokuti Elavil.
Amitriptyline inorondedzerwa se tricyclic antidepressant. Kwemakore, vamwe vanachiremba vakafunga kuti iyo inotangira mishonga yeutachiona ye fibromyalgia uye isingaperi inetaire syndrome ( ME / CFS ). Zvisinei, izvi zvakava zvakawanda kubva mukushandiswa kwekuedza-uye-kukanganisa pane zvidzidzo zvekliniki.
Mumakore achangobva kupfuura, kunyanya nekuuya kweRAA-inogamuchirwa nehutachiona hwehutano, kushandiswa kweamitriptyline nekuda kwezvirwere izvi zvakaderera. Amitriptyline achiripo, zvisinei, dzimwe nguva inoshandiswa sekutaura zvinodhaka mumishonga yekurapwa kwe fibromyalgia, uye vanachiremba vakawanda vachiri kuitaura nokuda kwemamiriro aya.
Iyo Inoshanda Sei
Amitriptyline nedzimwe mishonga tricyclic inofungidzirwa kuti iwedzere huwandu hwevana neurotransmitters serotonin uye norepinephrine iyo uropi hwako hunogona kushandisa. Vanoita izvi kuburikidza nekuderedza chirongwa chinonzi "reuptake," iyo apo masero anozivikanwa anoshandisa neurotransmitter kuitira kuti agone kushandiswazve kune imwe nzvimbo.
Zvimwe zvinotapukisa, zvinonzi reuptake inhibitors, zvinoshandisa nzira dzakasiyana-siyana kuti dzigone kuita zvakafanana.
Serotonin uye norepinephrine inofungidzirwa kuti inoparadzaniswa mu fibromyalgia uye ME / CFS.
Uyewo Ona:
Fibromyalgia
Kubvunzurudzwa kweAmitriptyline kwegore ra2012 kwe fibromyalgia kwaive nezvozvi kutaura pamusoro pemishonga yekushandisa kwechiropa mu fibromyalgia:
Amitriptyline yakange iri mutsara wokutanga wekutambudzika kweukama kwemakore mazhinji. Ichokwadi chokuti hakuna humwe uchapupu husingabatsiri hunobatsira hunoodza mwoyo, asi hunofanira kuenzaniswa nemakumi emakore ekubudirira kwehutano mune varwere vakawanda vane marwadzo europathic kana fibromyalgia. (Moore, et al, pasi.)
Kubvunzurudza kunoenderera mberi kutaura kuti kufungisisa kwekubudirira kwayo kunofunganya nekuti zvidzidzo zvenguva pfupi zvinoratidza chete vashomanana vevanhu vanoidza izvi vachava nemarwadzo anogutsa anogutsa.
Imwezve kudzokorora gore iroro, iro raisanganisirawo zvinodhaka zvinonzi deloxetine uye milnacipran, yakati:
Nhamba shomanana yevarwere vanowana ruzhinji rwekuregererwa kwechiratidzo pasina kana zvikanganiso zviduku. Zvisinei, nhamba inoshamisa yevarwere vanorega kuregererwa kwechirwere nekuda kwezvisingagadziriswi zvinokanganisa migumisiro kana ruzivo chete ruzoro ruduku rwezviratidzo, izvo zvisingasviki mhinduro dzakaipa. (Hauser, Wolfe et al, pasi.)
Kuongorora kwegore ra2011 (Clemons, et al, pasi) rakagumisa kuti amitriptyline haifaniri kutaridzirwa segoridhe-yepamusoro ye fibromyalgia nekuda kwekukanganisa kwezvidzidzo zvaive zvichiitwa.
Zvisinei, zvakare muna 2011, kuongororwa kwezvikwata zvezvinodhaka zve fibromyalgia (Smith, et al, pasi) zvakataura kuti amitriptyline yakanga yakafanana nemishonga inogamuchirwa neDAA - Lyrica (pregabalin), Cymbalta (duloxetine), uye Savella (milnacipran) apo vakasvika pakurwadziwa uye kuneta.
Vamwe vanachiremba vanogona kusarudza amitriptyline nokuda kwezvikonzero zvishoma:
- Nhoroondo yayo yakareba yekushandiswa, uye
- Mari yaro yakaderera yakaenzaniswa neDAA-inogamuchirwa nehutachiona hwechiropa.
Semuenzaniso, mwedzi mumwechete unopa maititic acid inogona kukwana pakati pe $ 15 ne $ 65, zvichienderana nesero. Panguva iyi, mwedzi mumwechete weCymbalta (duloxetine), Lyrica (pregabalin), kana Savella (milnacipran) inotanga kusvika madhora 125 uye inogona kusvika kusvika madhora 180. (Izvi zvinogona kuchinja sekuti generic duloxetine inouya pamusika.)
Kupera Kuneta Syndrome
Amitriptyline ine nhoroondo yakareba yekushandiswa kwe ME / CFS, zvakare pasinei nekushayikwa kwezvidzidzo zvekliniki uye nekuda kwechokwadi-nyika kuona kwekuvandudza. Tsvakurudzo shoma shoma yakaitwa.
A 2012 kuongorora, zvisinei, yakatarisa amitriptyline kuMe / CFS uye yakaona kuti ndiyo chete yevamwe vanorwara nehutachiona yakaedzwa iyo yakavhara mast-cell release yepro-inflammatory cytokines , iyo inofungidzirwa kuti inobatsira mu ME / CFS.
Dosage
Kuvanhu vakuru, chimiro chemaamitriptyline chirairo chinogona kubva kubva 40 mg kusvika 150 mg pazuva. Inowanzogoverwa kuva maitiro akawanda.
Inogona kutora chero yakareba semwedzi kuti iwe uone kuchinja kunoenderana nemishonga iyi.
Iva nechokwadi chekutevera mirairo yachiremba wako yekutora iyi mishonga. Kana iwe uchida kurega kuitora, usangomira pakarepo. Kumbira chiremba wako nezvenzira yakakodzera yokuderedza iyi mishonga.
Migumisiro Yechiri
Sezvo nezvose zvinotapukisa, zvinotakura nyevero pamusoro pehuwandu hwekuzviuraya kana kuedza kune vanhu vasati vava nemakore makumi maviri nemaviri.
Amitriptyline ine rwendo rukuru rwemigumisiro yemigumisiro. Migumisiro yakajairika inosanganisira:
- Unsteadiness,
- Nightmares,
- Nausea kana kurutsa,
- Kuoma kurinating,
- Constipation,
- Kuwedzerwa kwekufukura,
- Kuchinja muhukuru kana chido,
- Kuchinja mune zvepabonde kana kukwanisa kuita zvepabonde,
- Marwadzo, kupisa kana kutinhira mumaoko kana patsoka.
Kana uine chimwe chezviitiko zvinotevera zvakanyanya, unofanira kudana chiremba wako pakarepo:
- Kutaura zvishoma, kuoma kutaura,
- Kupera,
- Kushaya simba kana kushaya simba kwechimbwa,
- Kupwanya kurwadziwa kwepfupa,
- Kusagadzikana kwepfungwa,
- Kumhanyira kwakanyanya kana mikoko,
- Kukudzwa kwechiso uye rurimi,
- Ganda rejena kana maziso,
- Tsvina dzemuviri musana, mutsi uye shure,
- Kusagadziriswa kunetseka,
- Kubuda ropa kusina kujairika kana kupwanya,
- Kugumburwa,
- Hallucinations.
Nemhaka yokuti iyi mishonga inowedzera inowanikwa yakawanda ye serotonin, unofanirwa kudzivisa mamwe mishonga inowedzerawo serotonin uye kudzidza zviratidzo zvekukanganisa kuparadza: Serotonin Syndrome.
Sezvakaitwa nemishonga chero ipi zvayo, zvakakosha kuti iwe uye chiremba wako uremerhe njodzi pamusoro pezvibatsiro uye usarudze kuti zvipi zvinorapwa zvakakodzera kwauri.
Sources:
Clemons A, et al. Nyaya yemakiriniki psychopharmacology. 2011 Jun; 31 (3): 385-7. Amitriptyline uye prochlorperazine inhib proinflammatory murevereri anosunungurwa kubva kumunhu mast cells: zvichibvira zvakakosha kuva asingagumi kuneta.
Hauser W, Petzke F, et al. Rheumatology (Oxford.) 2011 Mar; 50 (3): 532-43. Kuenzanisa nekubudirira uye kugamuchirwa kweamitriptyline, duloxetine uye milnacipran mu fibromyalgia syndrome: kugadziriswa kwakarongeka nekuongorora meta.
Hauser w, Wolfe F, et al. CNS zvinodhaka. 2012 Apr 1; 26 (4): 297-307. Basa rekudzivirira mwoyo mukati mekutonga kwe fibromyalgia syndrome: kuongorora kwakarongeka uye meta-analysis.
Moore RA, et al. Cochrane database yekuongorora kwakarongeka. 2012 Dec 12; 12: CD008242. Amitriptyline nokuda kwehutano hweuropathy uye fibromyalgia kuvanhu vakuru.
Okea, R. American chiremba wemhuri. 2010 Oct 15; 82 (8): 901-904. Milnacipran (Savella) ye fibromyalgia.
Smith B, et al. Kirasi Yezvinodhaka Kuongorora. 2011 Kubva Kirasi Yezvinodhaka Ongororo: Mishonga yeFibromyalgia: Final Final Report.
US Food & Drug Administration. Amitriptyline Safety Alerts. Yakasvika munaSeptember 2014.