Zvinokonzera, Kuongororwa, nekurapa
Vanhu vanorarama nehurombo husingaperi dzimwe nguva vanovimba nemishonga yekurapa kuti vaite. Zvisinei, imwe yemhando dzakasiyana-siyana dzepainkillers inogona, nekushandisa kwenguva refu, kutanga kuita kuti marwadzo ako awedzere.
Kana izvozvo zvichiitika, inonzi opioid-induced hyperalgesia (OIH) kana opioid-induced allodynia (OIA). Hezvino izvo zvinoreva mazwi aya:
- Iopioid, dzimwe nguva inonzi opiate kana nharotic, inoratidzira painkiller yakagadzirwa nemafomu akaita opium.
- Hyperalgesia inowedzera kurwadziwa; Zvinoshandiswa muhurongwa hwemagetsi zvinoshanda kuti kuwedzere kuwedzera kwemarwadzo aunonzwa.
- Allodynia marwadzo anokonzerwa nechimwe chinhu chisingafaniri kukonzera marwadzo, akadai sechigunha chechiedza kana chirabwe chiri kutenderera paganda rako.
Apo opioid inotanga kukonzera kana kuwedzera kukura kwako, iwe unogona kunge uchida kusunungura kubva kwavari uye kutsvaga dzimwe nzira dzokugadzirisa nadzo marwadzo ako.
Kurwadziwa kweopioid-induced (OIP) kunogona kuva kwakaoma kufungidzira, kunyanya kune mumwe munhu ane chirwere chinenge chave chinosanganisira hyperalgesia uye / kana allodynia.
Opioids inowanikwa chete nemishonga. Mamwe madhiragi anongova opioid chete asi vamwe vanobatanidza opioid nemumwe mushonga unonzi acetaminophen. Opioid inowanzowanzosanganisira:
- Hydrocodone
- Oxycodone
- Codeine
- Morphine
- Methadone
- Fentanyl
- Meperidine
- Hydromorphone
Chii Chinokonzera Opioid-Inorwadza Inhamo?
Masayendisiti haasati aziva kuti chii chinokonzera OIH. OIA yakazivikanwa zvikuru munguva ichangopfuura uye tinoziva zvishoma nezvayo kupfuura isu OIH.
Zvisinei, vatsvakurudzi vari kutsvaga mikana yakawanda.
Maererano nekuongorora kweOIH yakabudiswa mupepanhau Pain Physician, dzimwe nzira dzinogona kuitika dzinosanganisira:
- Kusakanganiswa nenzira iyo uropi hwako hunoita zviratidzo zvinorwadza
- Zvimwe zvinogamuchirwa mumakumbo ako zvisina kunaka
- Kuwedzerwa kweeurotransmitter glutamate , iyo inokurudzira masero ako europi, dzimwe nguva pamusoro-kuvakurudzira kusvikira pakufa
- Basa rakawandisa rezvinyorwa mumutsipa wepelinha zvinokurudzira mishonga yakananga, inonzi nociceptors , mumamiriro ako eropa nervous system
- Kuderedza reuptake kune dzimwe nyanzvi dzemaurotransmitter, dzinoramba dzichikwirira zvakasimba muuropi
- Kukanganiswa kwemasimba emagunha emakumbo emakumbo emumutsipa ( P ) iyo inotumira manzwiro ekurwadziwa uye gemutamate
Zvimwe zvezvirongwa izvi zvinogona kushanda pamwechete kuti zviite nekuchengetedza OIP. Kunyange zvazvo ruzhinji rwekutsvakurudza rwave rwakaisa pamusoro penheyo yenheyo, hurongwa hwehutachiona hunogona kunge hunobatanidzwa mune zvimwe zviitiko.
Chirwere Chirwere chinorondedzera chinoratidza humwe uchapupu hwekuti OIP inogona kukura zvakasiyana kana ichiuya kune marudzi akasiyana ekutambudzika, pamwe chete.
Ndiani Ari pangozi yeOpioid-In-Pain Pain?
Haasi wose anotora opioid achakudziridza OIP. Kutsvakurudza kunoratidza kuti mageneti anogona kuita basa. Kutora opioid nguva refu kwenguva refu kunowedzera dambudziko rako, sezvinoita kutora doses. Kukurumidza kukura muyero wako zvakare kunokuisa iwe pangozi yakakwirira.
Nemhaka yokuti vanhu vazhinji vanotanga kushivirira mishonga iyi, zvinowanzoenderana nemari yaunotora kuti uwane kurwadziwa kusingaperi kwenguva refu, zvinoreva kuti iwe unowedzera uye unowedzera kukura OIP.
Kuongororwa Opioid-Induced Pain Pain
OIP yakaoma kuziva.
Hapana chiyero kana kuchinyorera, saka chiremba wako anofanira kutarisa zviratidzo zvako uye kutarisa zvimwe zvinokonzera kuwedzera kana kurwadziwa mutsva. Izvi zvinonzi kuongororwa kwekuregererwa, nokuti inogona kugadziriswa apo dzimwe mikana dzisingabatanidzwi.
Chimwe chipingamupinyi chakakomba pakuongororwa kweOIP chirwere chinoshungurudza chinowedzera izvo zvinonzi "kurwadziwa pakati" kana " kusimbisa pakati ." Izvi zvinosanganisira fibromyalgia , rheumatoid arthritis , migraine , inokanganisa bowel syndrome , ME / chronic kuneta muviri , uye mushure mekutambudzika kunetseka kwepfungwa. Vanhu vane mitemo iyi kazhinji vanotova ne hyperalgesia uye / kana allodynia, iyo inogona kuvhara OIP.
Pasinei nokuti chii chinokonzera marwadzo ako, chinhu chinokosha chaunofanira kutarisa ndechekushandura kwakasimba kana chimiro chekutambudzika kwako. Tarisa mhando idzi dzekuchinja:
- Kuwedzera kunopararira kana kuparadzanisa kurwadziwa kana chinokonzera chikonzero chichigadzikana kana kuti chiri nani
- Kuwedzera kunorwadza kunetseka pasinei nechechi chinokonzera chigadzikane chakasimba kana kuti chiri nani
- Kuwedzera kunorwadza mushure mokunge maopioid yepamusoro inokwira
- Kuderedza marwadzo paunotora zvishoma painkillers
Kana uchikwanisa kuudza chiremba wako nezvekutambudzika kwako kwakashandurwa uye kuti ingabatana sei nekushandiswa kwako kweopioid, zviri nyore kuti uwane mufananidzo wakajeka wezvinoita kuti utambudzike.
OIP vs. Kuwedzerwa Kwemishonga Kushivirira
Kuomesa chirongwa chekuongorora kunowedzera kushivirira kwemishonga. Kushandiswa kwenguva refu kwemishonga iyi inonyatsozivikanwa kuti inotungamirira kune kuwedzera kushivirira, izvo zvinogona kutungamirira nguva dzose kuwedzerwa dheji.
Saka dzimwe nguva, zvinorwadza zvinokwira kwete kwete nokuti maopioid ari kukonzera, asi nokuti iwe wakagadzira kushivirira kumishonga, izvo zvinoreva kuti haisi kushanda sezvakashandiswa. Unozivisa sei kusiyana?
Hazvisi nyore. Iva nechokwadi chekutaura nachiremba wako pamusoro pezviri kuitika uye kuti ungaziva sei chinokonzera marwadzo ako. Kuongorora nemero yako iwe pachako kunogona kuva nengozi zvikuru, uye inogona kusakupa ruzivo rwakakosha.
Kurapa Opioid-Inotambudzika kurwadziwa
Kana chikonzero chekurwadziwa kwepanyika chakanga chaenda, zvino kurapa kunonzwisisika ndekubva kune opioid. Zvichienderana neyero uye kuti yakatorwa kwenguva yakareba sei, izvo zvingadikanwa kugadzirisa zvishoma nezvishoma nzira yekudzivisa kuchengeta zviratidzo.
Kana, zvakadaro, chinokonzera kurwadziwa chiri kupfuurira, chiremba wako anogona kukurudzira kuderedza muyero kuti uone kana izvozvo zvichibvisa OIP. Paunenge uchienda kune opioid, zvinoita kuti hutano hwako hweOIP huve hunova hwakaipa kupfuura imwe nguva usati waenda.
Iwe unogonawo kuwana zororo nekushandura rudzi rweopioid yaunoshandisa. Somuenzaniso, hydrocodone, fentanyl, uye tramadol zvose zvinobva kumakero akasiyana.
Dzimwe nguva, vanachiremba vanoedza kuwedzera imwe yakasiyana-siyana yepainkiller-ingava COX-2 inhibitor kana kuti isiri-steroidal anti-inflammatory (NSAID) -kuita nehana shoma yeopioid. Iyi mishonga inogona kubatsira kubvisa zviito zvisingaenzaniswi zve glutamate uye zvinhu P izvo zvinotendwa kuti zvinopa mamwe maitiro eOIP.
Mimwe mishonga inogona kubatsira mukurapa OIP inosanganisira:
- Dextromethorphan
- Methadone (kana OIP isiri methadone-yakabatana)
- Buprenorphine
- Ketamine
- Dexmedetomidine yakabatana ne flurbiprofen axetil
The supplement curcumin (chinhu mu spice turmeric) inogona kuchinja OIH, maererano nekudzidza muna 2016 mu PLoS One .
Muchidzidzo cha2016 chakabudiswa muScientific Reports , vatsvakurudzi vakatsanangura kuti kuchinja kweimwe rudzi rwe stem cell rakadzokorora OIH uye morphine kushivirira.
Kudzivirira Opioid-Induced Pain
Zvechokwadi, zviri nani kana iwe uchigona kudzivirira OIP panzvimbo yekutanga. Chidzidzo che 2017 chakabudiswa muZvino Opinions muAnaesthesiology inokurudzira kufambisa kuburikidza nemirasi yeopioid, kugara paanotadza kuenzanisa, nekubatanidza maopioid nevasina opioid painkillers. Kunyora kumazinga akakwirira zvishoma nezvishoma kunogona kuchengeta OIP kubva pakukura.
Unogonawo kutsvaga mishonga isiri yemishonga yekurwadziwa kwako kubatsira kuchengetedza kushandiswa kwewapioid yako pasi asi kwete kukanganisa hupenyu hwehupenyu.
Non-Mishonga Pain Treatments
Mishonga isina kodzero yemishonga kwauri inobva pane zvinokonzera kurwadziwa kwako uye chimwe chinhu chaunofanira kutaura nechiremba wako. Kuvhiringidzika kunowanzoitika kunosanganisira:
- Acupuncture
- Massage therapy
- Physical therapy
- Chiropractic
- Biofeedback
- Kuchengetedza maitiro therapy
- Zvigadzirwa
Vamwe vanhu vane marwadzo asingagumi vanowana zororo kubva mukudzidzira zvinyoro zvakadai se:
Shoko Rinobva
Kana iwe ukacherechedza kuwedzera kwekutambudzika kana kuchinja mumamiriro ekurwadziwa kwako, taura nachiremba wako pamusoro pekuti ingave yakakonzerwa neopioid yako. Utano husingaperi hunotora huwandu hwehupenyu hwehupenyu hwako sezvauri-haudi mishonga yako ichikukuvadza zvakanyanya!
Kana iwe nachiremba wako musarudza kuti iwe unofanira kumira uchiitora, iva nechokwadi chokuti unodzidza kuregera kubva nayo zvakanaka uye kutevera mirairo.
Nezvinodhaka izvi, kukanganisa zvinogona kuitika. Hazvina kunyadziswa mune izvo-zvinokonzerwa nemuviri wemishonga. Zvisinei, zvinogona kureva kuti unoda rubatsiro rwakawedzerwa. Ichocho chimwe chinhu chinokurukura nachiremba wako.
Zvinogona kunyanya kutyisa kurega kutora mishonga yawakavimba nayo kuti iite. Edza kuisa pfungwa pahuwandu hwahwo hunogona kuderedza marwadzo ako nekuvandudza hupenyu hwako, uye yeuka kuti une zvimwe zvinorapwa kuti uongorore.
> Sources:
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> Li SQ, Xing YL, Chen WN, et al. Kushandiswa kweNMDA receptor kunobatanidza ne-up-mutemo we COX-2 kutaura mumusana wepinal dorsal horn munguva yemaiciceptive maitiro mumakonzo. Neurochem Res . 2009; 34: 1451-1463.
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> Yu Z, Wu W, Wu X, et al. Zvidziviriro zvinokonzerwa ne dexmedetomidine pamwe chete ne flurbiprofen axetil pamusoro remifentanil-induced hyperalgesia: chirongwa chinotaridzika chinotungamirirwa. Mishonga yekuongororwa uye yekurapa. 2016 Oct; 12 (4): 2622-2628.