Zviitiko Zvinoshamwaridzana Zvinosangana Nezvinyorwa Zvitsva kana Makomiti NSAID Zvingakubatsira Iwe Kugadzirisa
Nonsteroidal anti-inflammatory drugs (NSAIDs) ndeimwe yemishonga inonyanya kuzivikanwa uye inowanzopiwa yeArthritis. NSAID dzinogona kutorwa nemuromo kana mapepa, capsules kana mvura. NSAIDs dzinowanikwawo mune zvinyorwa zvemashoko, sekrimu, gel kana mvura inoshandiswa paganda.
Nzvimbo dzeTopical NSAIDs Dzinoshanda Sei?
Nyaya dzepamusoro NSAIDs, dzakadai setiopi ibuprofen kana Voltaren gel , dzinoshandiswa paganda pamusoro pekubatana kunorwadzisa.
Kune humwe hufumi hwakabatanidzwa kune zvinyorwa zveNSAID zvinosanganisira:
- kukurudzirwa kwezvinodhaka zvinoshandiswa kune hutachiona
- kuderedza kuwanda kwemigumisiro yakashata yakaipa yakadai sepptic ulcer zvirwere uye kubuda kwepamuviri ropa
Nyaya dzepamusoro NSAID dzinopinda zvishoma nezvishoma, zvichiendesa zvishoma zvishoma mumashandisirwo emagetsi. Zvichienzaniswa nemitemo yeNSAIDs, nhepfenyuro yepamusoro inotungamirira kune yakanyanya kukwirira kweNSAID kuisa mumvura (yakasara ganda riri pasi pe epidermis ine mavara anobatana). Mafungiro akawanikwa mumisungo yemaviri iri pasi pezvimbo yechishandiso yakasiyana, asi inenge yakaenzana neicho chinobudirira nemuromo kutungamirirwa kweNSAIDs.
Nyaya dzepamusoro NSAIDs dzinosvika pane synovial fluid , asi yakawanda sei uye nenzira ipi chaiyo isati yagadziriswa. Kusiyana kwega kwega pega paganda kunogona kutarisa zvimwe zvakasiyana-siyana zvinowanikwa mukudyiwa kwemashoko eNSAID.
Kazhinji kutaura, zvakaoma kuziva kana maSIDI ari munyaya dzepamusoro kana mumuromo ari nani nokuti akaratidzirwa kuti mumakiriniki ekuedzwa kune nzvimbo yakakwirira yepa placebo.
Vanhu vanotaura nezvekununurwa kwehurombo kunyange kana pasina chekushandisa chinoshanda pamapiritsi kana kamuti.
Ko Oral NSAIDs inoshanda sei?
Nhengo dzeNSAID dziri mishonga, mapiritsi kana mishonga yemvura inomedzwa. Vanopfuura nepakati pemagetsi uye vanopinda muropa, vachiva nemigumisiro mumuviri wose. Nhengo dzeNSAID dzakashanda nekudzivisa cyclooxygenase (COX) , iyo enzyme inobatsira arachidonic acid kune prostaglandin uye leukotrienes.
Arachidonic acid inosunungurwa kubva pamabhanana phospholipid inopindira kune zvinokonzera kupisa. Prostaglandins inogadzira kupisa kwekupindura. NSAID dzinopesana nekugadzirwa kwe prostaglandin nekudzivisa cyclooxygenase.
Kusiyana Muzviitiko Zvakaipa Pakati Pemashoko uye Nheyo NSAIDs
Nyaya dzepamusoro NSAID dzine unhu huri nani hwekuchengetedza pane zvinyorwa zveNSAID. Zvinosvibisa zvinoshandiswa kune zvinyorwa zvepamusoro NSAID inoshandiswa inenge inenge 10 kusvika ku15% yevarwere uye inonyanya kugadzirwa (rash uye pruritus - kuchema - apo NSAID yenyaya yepamusoro yakashandiswa). Kuita kwepabonde kusagadzikana kwezvipembenene zvinodhaka hazviwanzove neongororo dzeNSAID, kana zvichienzaniswa nezvakaitika zve15% zvakataurwa mumuromo weNSAIDs.
Maitiro Evanhu Vanorwara Vanosarudza Pakati Pemuromo uye Nhepfenyuro NSAIDs
Kubva pamishumo miviri yakabudiswa muBrithani Medical Journal (BMJ) , zvakava pachena kuti chisarudzo pamusoro pekushandiswa kweNSAID, muromo kana nheyo, kushandiswa kunowanzo:
- kushivirira kuoneka kwengozi yemigumisiro yakaipa
- kuvapo kweimwe chirwere
- zvinorwadza
- mazano akapiwa
- kuita zvinodiwa (mari uye nyore zvekushandisa)
Mune BMJ , vatsvakurudzi vakapedzisa kuti "nhau dzeNSAID dzinoshandiswa, dzakachengeteka, dzakachengeteka kumuromo NSAIDs kuitira kurapwa kwemafupa osteoarthritis , kunyange kana nzvimbo inonzi effectbo inotsanangura huwandu hwohuwandu hwemashoko ekunyora."
Sezvo nguva dzose, kurukurai zvamunogona kuita nachiremba wenyu uye shingai pamwe chete kuti muwane iyo ndiyo yakanakisisa sarudzo yemamiriro enyu nemamiriro ezvinhu.
> Sources:
> Nyanzvi inopesana nesheji NSAIDs muzvirwere zverheumatic: kuenzanisa. Zvinodhaka. 2000 Sep; 60 (3): 555-74. Heyneman CA et al.
> Mhemberero nenyaya yepamusoro NSAID yekutambudzika kweOA - sei uye nei vanhu vakasarudza mishonga. December 5, 2007. > UKMiCentral >. NHS.