Iyi Nzira yeBongo Inowanzoshandiswa Kubata Kurwara kwaPalinson
Zvinonzwika sechimwe chinhu kubva kune vanogadzira Star Trek, asi vatsvakurudzi vari kuona mikana inotanga nekushandiswa kwepfungwa dzakadzika kukurudzira kune vanhu vane chirwere cheAlzheimer's mild. Uye, munyika iyo mishonga inowanikwa asi zvikomborero zvisingakwanisi, zvakakosha kuti ienderere mberi nekurapa mamwe maitiro ekurapa nekudzivirira nekudzivirira Alzheimer's.
Chii Chiri Pakadzika Bongo Kukurudzirwa?
Kubwinya Kwepfungwa Kukurudzira (DBS) inzira iyo magetsi anoiswa mukati meuropi uye akarongwa kuti ape zviduku zvemagetsi zvinokurudzira kuita zveuropi.
DBS yakashandiswa kwemakore anoverengeka kune vanhu vane chirwere chePasinson vane kubudirira kukuru mukudzikisa kudengenyeka kwemitsipa uye misuli zvinopesana, pamwe nekuvandudza mafambiro. Inenge ichitsvakurudzwa kurapa mamwe mamiriro ekurapa, akadai sokuora mwoyo uye kuora mwoyo -kusagadzikana kwepfungwa .
Ko Electrodes Inowanikwa sei muBongo?
Mhinduro shomanana: chirwere cheuropi. Kuti DBS iwanikwe, waya anofanira kuiswa muuropi. Kushandisa anesthesia yemunharaunda , chirwere chinonzi neurosurgeon chinodonha muhomwe remu murwere uye zvinonongedza faira munzvimbo dzakasiyana dzeuropi. (Local anesthesia, kana murwere achimuka asi nzvimbo yomuviri inowedzerwa, inogona kushandiswa nokuti ubongo pachahwo hahugoni kunzwa kurwadziwa.)
Shanduro yemagetsi inonzi pacemaker inobva yasimwa pasi peaneshesia yose muchipfuva chemunhu apo inogona kupedzisira inounza 130 mashizha emagetsi mashizha pamasere uye, nokudaro, uropi. Pakutanga kuiswa, stimulator inodzimwa; mazuva mashomanana kana masvondo mushure mekuvhiyiwa, iyo stimulator inotenderera uye inotanga kusunungura mafungiro emagetsi kuuropi.
Kana yakashandiswa kurapa chirwere cheAlzheimer, iyo faira inowanzobatana nefornix muuropi. Maererano naJohn Hopkins Medicine, "fornix inzira yeuropi inobatsira pakuunza mashoko kune hippocampus , chikamu cheropi apo kudzidza kunotanga uye zvinorangarirwa zvinoitwa, uye apo zviratidzo zvekutanga zveAlzheimer zvinowanzobuda."
Kubwinya Kwebasa Kunokurudzira Basa?
Pane maverengeka akawanda ekuti nei achishanda, asi hapana mhinduro yakakwana asi zvakadaro. MuPasinson, inofungidzirwa kuti inopesanidza uye inoparadza kukanganisa kwakaipa kweuropi.
Kutaura zvazviri, kunzwisisa kwevatsvakurudzi veDBS kwakanyanyisa kuti mukana wekushandisa iyo kweAlzheimer yakawanikwa nenzira yengozi apo DBS yaive ichiedzwa kune murume akanga ane urombo zvakanyanya seipi nzira yekuedza kudzora kuda kwake. Sezvavakanga vachimuedza nematareji akaiswa uye mafungiro emagetsi, akarondedzera chiyeuchidzo chakajeka. Pavakazobvisa mafungiro acho, chiyeuchidzo chakabva chaenda, uye pavakashandura iyo stimulator zvakare, chiyeuchidzo chakadzoka. Izvi zvakaita kuti kuziva kuti pane imwe nzira yekukurudzira uropi uye zviyeuchidzo zvayo.
Yakachengeteka here?
DBS inoita seyakachengeteka. Kunyangwe pfungwa yekuvhiya kweuropi inonzwika yakaipisisa, nyanzvi dzinoti nzira iyi haisi yekuti inopisa sezvinonzwika.
Iko kune nguva dzose njodzi nekuvhiya kweuropi; zvisinei, vanhu vanopfuura 100 000 munyika yose vane chirwere chePasinson vakawana DBS vane zvinetso zvishoma. Ngozi dzinosanganisira kutapukira, kushandiswa kwemichina, kushungurudza, kusakosha kwebheteri, uye kufamba kwetambo.
Tsvakurudzo paKubata kweBurin Kukurudzira uye Kurwara kweAlzheimer
Phase I Ongororo
Muna 2010, magazini reAnals of Neurology rakabudisa tsvakurudzo inotsanangura chikamu I kliniki yekuedzwa yakaitwa muCanada nevanhu vatanhatu vakawanikwa vane chirwere chekutanga cheAlzheimer's. Mumwe nomumwe aiva nehupamhi hwepfungwa dzakagadzirisa chirwere mumakumbo avo uye akaziva mwedzi 12 yekuenderera mberi kwekusimudzira magetsi.
Kuongororwa kwemaitiro avo ekugogodza pamwedzi 6 ne12 kwakaratidza kuvandudzwa, kana kuderera kudarika-kunotarisirwa kune vatatu vevatanhatu vatori vechikamu.
Uyezve, zviratidzo zvePET zvakashandiswa kuongorora kubata kweglucose metabolism, iyo kukwanisa kweuropi kuputsa shuga dzehuropi uye kunogonawo kuva chiratidzo chezviitiko zveeurouroni muuropi. Vanhu vane Alzheimer vanowedzera kuderera kweglucose metabolism kwekufamba kwenguva, asi ava vatanhatu vanoongorora tsvakurudzo vakaratidza kuwedzerwa kwakachengetedzwa muchidzidzo chacho. Zvinofadza kuti kuora kwehuropi kuputsa shuga muAlzheimer's disease kwakaita kuti vamwe vatsvakurudzi vati Alzheimer's " type 3 chirwere cheshuga ."
Phase II Research
Muchikamu chechipiri chekudzidza kuburikidza naJohn Hopkins, varwere 42 vane makore 45 kusvika ku85 vakapinda muchirongwa cheDBS kuti vatarise chirwere cheAlzheimer's. Mumwe nomumwe akabata chirwere cheDBS chekugadziriswa pakati pe2012 na2014. Hafu yavo yakange iine vatsigiri vavo vakashandura mushure memavhiki maviri, uye hafu yavo yakave yakashandurwa pashure pemwedzi gumi nemaviri. Ichi chaive chifukidzo chekupofumadzwa kaviri, sezvo kunyange vanachiremba kana varwere vaisaziva apo vafuridziri vakagadzirwa.
Cognition yakaongororwa muchidzidzo ichi kuburikidza nemuedzo wakawanda kusanganisira ADAS-Cog 13. Cerebral glucose metabolism yakayevedzwa munzvimbo dzakasiyana dzeuropi.
Migumisiro yenyaya iyi yaive inonakidza, uye kwete chaiyo yaitarisirwa. Pakapera mwedzi mitanhatu mushure mekugadziriswa kwekusimudzira, chirwere cheglucose metabolism chawedzera zvikuru, asi izvo zviwanikwa hazvina kusimbiswa mwedzi gumi nembiri. Uyezve, kusiyana-siyana kwakabatana munguva yekupindura kwakaonekwa. Vaya vaive nemakore anopfuura makumi maviri nemashanu vakaratidza kuvandudzwa kwemagariro ekugogodza uye muhutachiona hwemashuga. Vaya vakanga vari pasi pemakore makumi matanhatu nemashanu havana kuratidza kuchinja kukuru kune imwe nzvimbo. Vatsvakurudzi vakatsanangura kuti izvi zvinogona kunge zvakabatana nemamwe nguva hukuru hwehuropi hunovhiringidza muvanhu vaduku neAlzheimer's ( kutanga kweAlzheimer's ), zvichienzanisa neavo vanotanga kubuda Alzheimer's.
Chidimbu cheDBS Migumisiro paBongo
Migumisiro yeDBS paAlzheimer yakadzidzwa kuburikidza nezvikamu zvekutanga I uye chikamu chechipiri chemakiriniki, asi ruzivo rwokuti runokanganisa sei uropi rwakabatanidzwawo kubva pakushandiswa kwaro kune dzimwe nzvimbo, kusanganisira zvimwe zvidzidzo zvekutsvakurudza uye mukurapa chirwere chePasinson. Zvinotevera zvinowanikwa:
Kuvandudzwa kwekugadzirisa cognition: Kutsvakurudza pamusoro peDBS kune vanhu vane Alzheimer kwakaguma nekuvandudza kugadziriswa kwevamwe vevatori vechikamu, sezvinoenzaniswa neongororo yakawanda yeurouropsychological . Aya maedzo anoyera zvinhu zvakasiyana-siyana zvehuropi kushanda, kusanganisira kuyeuka, kutaridzika , kugamuchira shoko, nezvimwe.
Kuwedzera kwechi hippocampus izwi: Kunyange zvazvo hippocampus (chikamu cheropi chinobatanidza nekuyeuka) maharasi nehupo hwekukwegura uye zvakanyanya muAlzheimer's disease, DBS yakawanikwa kuwedzera huwandu hwemukoko kune vanhu vane Alzheimer's. Hippocampal volume yakabatanidzwa nekumhanya kushanda.
Kuwedzerwa kwehutachiona hweglucose metabolism: Sezvakaratidzwa pamusoro apa, dzimwe dzidzo dzakagamuchira DBS dzakaratidza kuti dzakagadziriswa glucose metabolism munzvimbo dzakasiyana dzeuropi.
Kuwedzera kwehuwandu hwemapurisa uye miviri yemamera: Ifornix uye miviri yemamera muuropi (iyo iyo yose inobatana nekuyeuka kushanda) yakaratidza huwandu huwandu pashure peDBS kune avo vane Alzheimer's.
Higher acetylcholine levels: DBS yakave yakaratidzwa mukutsvakurudza kunotanga kusunungurwa kweacetylcholine. Acetylcholine inobatsira kutumira mameseji kubva kune imwe nhengo yesero kusvika kune inotevera muhutano hwedu.
Kuwedzera kwekuyeuka kwemukati: Pashure pokudzika kwehuropi kukurudzira kufornix yemakonzo, vakaratidza kuvandudzwa kwepfungwa yekuyeuka mukukwanisa kwavo kuenderera mberi maze. Kunyange zvazvo zvidzidzo zvezvipfuwo zvisingawanzoenderi kune vanhu, dzinowanzotipa mazano pamusoro pekuchengetedzwa uye kubudirira kwekuongorora nzira.
Kupera kwekutaura kwakanzwika: Uropi hukuru hunokurudzira hwave huchishandiswa kwemakore kune vanhu vane Parkinson vane zviitiko zvakakosha zvikuru. Zvisinei, kumwe kutsvakurudza kwakawana kuti kutaura kwemashoko kunononoka kune vamwe vevanhu ava. Nepo vazhinji vane Parkinson vachinzwa kuti dambudziko iri rinofanirwa nekubatsirwa kwakadzidziswa nehupfungwa hwepfungwa. zvinogona kunge zvisingaiti nyore kuonekwa sengozi inobatsira kune avo vane chirwere cheAlzheimer.
Kufungisisa Maitiro
Kunyange zvazvo pane zvidzidzo zvakawanda zvakaitwa nevanhu, vamwe vatsvakurudzi vari kukumbira kuwedzerwa nekuwedzerwa zvidzidzo vachishandisa DBS mumhuka vasati vaenderera mberi nekutsvakurudza nevanhu. Vanotaura kuti kunyange zvazvo pane DBS tsvakurudzo dzevatsvakurudzo dzakaona humwe huri nani hwekugadzirisa, pane zvakare vamwe vashoma vakaramba mune dzimwe nzvimbo dzinonzwisisika mushure mekunyanya kukwidziridzwa kweuropi.
Ava vanotsvakurudza vanosimbisawo chokwadi chokuti pane kusava nekunyatsonzwisisa kwokuti kunamatira kwakadzika kweuropi kunoshanda sei; saka, vanokurudzira kuti mamwe mashoko anowanikwa vasati vakura kuongororwa kwekliniki nevanhu.
Shoko Rinobva
Uropi hwepfungwa hunokurudzira hwakanyatsogadziriswa sehutano hwakakodzera hwePalinson's disease; zvisinei, tsvakurudzo dzakawanda dzinodiwa kuti dzione mararamiro ayo muAlzheimer's disease. Mikana yeDBS yekugadzirisa kugadziriswa kunofadza, kunyanya sezvo isu tichiramba tichinetseka kuwana mishonga inoshanda yeAlzheimer's.
> Sources:
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