Depakote Zvinyorwa uye zvimwe zveValproate Mafomu
Valproate mishonga inorondedzerwa seanticonvulsant mishonga uye naizvozvo inowanzotarisirwa kuti itadze kugadzirisa. Inorayirwawo pane dzimwe nguva kudzivirira migraine misoro uye kuderedza mapoka evanhu mu bipolar disorder. Vamwe vanachiremba vanorayirawo kuti vabate mararamiro anorwadza muAlzheimer's disease uye mamwe marudzi ehutano hwemangara .
Kushandisa valproate nenzira iyi kunofungidzirwa kusina -label sezvo isina kubvumirwa neU.S. Food and Drug Administration (FDA) kuitira kushandiswa.
"Valproate zvigadzirwa zvinosanganisira valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, uye Depakote ER), valproic acid (Depakene na Stavzor), uye ma generics," maererano neCDA.
Mafomu Akasiyana eValproate
Valproate inouya nenzira dzakasiyana-siyana, kusanganisira mahwendefa, mahwendefa akawedzerwa-akabudiswa, capsules ne valproate sprinkles (idzi capsules dzinogona kumedzwa zvizere kana kuvhurwa uye zviri mukati zvinosaswa pazvinyoro zvishoma kune avo vane zvakaoma kumedza) uye majekesiti / IVs kune avo vasingagoni tora mishonga yemuromo.
Sei Valproate Ichishandiswa Kuchirwa Nharo Dzakaoma Dhementia?
Chimwe chezvinetso muAlzheimer's disease ndechokuti unhu uye maitiro anokwanisa kuchinja sechikonzero chechirwere. Zvimwe zvemaitiro akaoma mumararamiro zvinogona kusanganisira kushungurudzika , kusazvidzora, kushamwaridzana , kushungurudzwa kwemashoko , kushorwa kutarisira, kutenderera uye kufunga kwepanoid .
Zvinogona kuva zvakaoma kuziva nzira yekuita nayo kune marudzi aya emitemo uye manzwiro.
Vezvechiremba vakaedza mishonga yakasiyana-siyana kuedza kuderedza maitiro aya, kusanganisira antipsychotic mishonga (iyo inogona kuva nemigumisiro yakaipa yemigumisiro uye yakanyatsorongedzwa mumushandi wekuchengetedza musha), benzodiazepines (iyo inouyawo nemigumisiro yakaipa uye kubudirira kunovhiringidzika) uye antidepressants (iyo isiri nguva dzose inoshanda kana yakakodzera).
Chinonyanya kukosha ndechekuti pane kazhinji haisi mishonga inobatsira zvikuru yekubata kushungurudzika kwetsika mukuderedza mwoyo .
Nokudaro, valproate rose semakwikwi mukuedza kugadzirisa kushungurudzika muhutano hwemararamiro. Mukuwedzera kune tariro yaro kuva mushonga unobudirira, valproate yakanga yakakwanisa kuva mishonga iyo yakatanga kuenderera mberi zvishoma pasi peradar maererano nemitemo yekuchengetedza musha-iyo yakanyanya kunyanya kugadziriswa uye kuparadzwa kwemishonga inorwisa antiyythin in dementia asi kwete seinofunga nezvev valproate.
Ko Valproate Inofanirwa Kufanirwa Kubata Zvinetso Zvisingabatsiri muDementia?
Maererano neongororo dzakawanda dzekutsvakurudza, mhinduro ndeyekuti: Kwete.
Kuregererei?
Inowanzoshaya basa. Kunyange zvazvo kune dzimwe nzvimbo dzisinganzwisisiki dzehutano hwekubudirira, kuongororwa kweongororo dzakawanda kwakagumisa kuti valproate yakanga isiri iyo inobatsira kupfuura nzvimbo ye (placebo (piritsi yakaipa) mukuderedza zvinetso zvakaoma zvekuora mwoyo.
Maererano nedzimwe dzidzo yakabudiswa muJAMA Psychiatry , valproate yakakundikana kukonzera kuderedza kufungisisa kwekuita kwemaonero evanhu, tariro yakatarisira iyo isina kubuda nekushandiswa kwayo.
Migumisiro Yechiri
Ongororo dzakawanda dzakawanawo kuti vatori vechikamu vakagamuchira valproate vaiva pangozi yakawanda yemigumisiro kubva pamishonga.
Iyo migumisiro yemigumisiro yakaisanganisira thrombocytopenia (yakaderera maplatelet eropa), kudengenyeka kwekuwedzera, kushungurudzika kwegadziriro, kudengenyeka, kusuruvara uye kurara, kushungurudza, kurutsa, uye kurora.
Alternatives kuValproate
Panzvimbo pokusvitsa bhodhoro remishonga kugadzirisa mafambiro akaoma mukuora mwoyo, nzira yekutanga inofanira kuva nguva isiri yemishonga . Chimbofunga zvinhu izvo zvingave zvichikonzera maitiro akadaro akadai semamiriro ekunze , kurwadziwa mumuviri , kusagadzikana kana kusagadzikana uye edza kutarisa uye kugadzirisa izvo zvinokonzera zvinokonzera.
Shandisa nzira dzakadai sokubvumira munhu nguva yekudzikama ari oga uye achidzoka gare kuti apedza basa raunenge uchiedza kuita.
Pakupedzisira, cherechedza kuti mutarisiri wekushungurudzika nekutsvaira kunogona kuwedzera maitiro eumwe munhu ane dhementia. Zviongorore iwe pachako kune zviratidzo zvekuchengeta mutoro uye kushandisa mhuri, shamwari uye nzvimbo dzemunharaunda kuti akutsigire mune basa rako rekuchengeta.
Shoko kubva
Zvakajairika uye zvakakodzera kutsvaga kurapwa kunobatsira nemaitiro akaoma anowanzokura muhutano hwehutano. Zvinosuruvarisa, isu tisati tawana mishonga inogara yakachengeteka uye inobudirira nokuda kwechinangwa ichi.
Nokuda kweizvi, iva nechokwadi chekutsvaga rubatsiro sewe muchengeti sezvo zviratidzo zvekuzvibata uye zvepfungwa zvekushaya mungozo zvinogona kuomesa kushanda. Izvi zvinogona kukubatsira kuti uchinzwe usisina kurega uye kubvumira vanotarisira kugovana nzira dzakasiyana dzave dzakabatsira ivo.
> Sources:
> ClinicalTrials.gov. Valproate mu Dementia (VALID). July 6, 2010.
> Database yeCchrane yeKugadzirwa kweChechi. 2009 Jul 8; (3). Valproate Kugadzirira Kurwisana muDementia.
> Depakote. Depakote Formulations.
> JAMA Psychiatry. Chronic Divalproex Sodium kuAttenuate Kushungurudza uye Kurwara Kuwedzera kweAlzheimer Disease.
> Mental Health Clinician. 2012; 1 (11): 14. Kusarudzwa kweValproate muVanhu Vakura Vane Dhementia: Kuongorora Kurambidza uye Dose Kuderedza.
> US Food and Drug Administration. Valproate Information.
> Williams, L. Vose Vakashanda Nezvehuchapupu: Valproate for Agitation in Dementia.
> Yeh, Y. uye Ouyang, W. (2012). Mafungiro emagadzirirwo ekurapa maitiro ekuzvibata uye mupfungwa mazviratidzo zvekuora mwoyo kwemuviri: Ongororo yekuvandudzwa. The Kaohsiung Journal of Medical Sciences , 28 (4), pp.185-193.