Pick's Disease and Corticobasal Degeneration Kunobatsira Circadian Rhythms
Kutenda kwepamberi yekambani yakadai sePick's's and corticobasal degeneration inobata kurara? Dzidza nezvemamiriro ezvinhu aya, kusanganisira zviratidzo zvavo zvakajairika, uye kuti kuora mwoyo kweikuita kunokonzera kusangana kwepakutanga uye nguva dzouropi zvinokonzera kurara uye circadian rhythms.
Chii chinonzi Frontotemporal Dementia?
Dhementia inosanganisira zvinetso zvakasiyana-siyana zvinochinja huropi uye zvingakanganisa pfungwa, kutarisa, unhu, mutauro, kugadzirisa matambudziko, uye basa rezuva nezuva.
Munharaunda iyi yakafara, kune mamiriro ezvinhu anokonzera nzvimbo dzakasiyana dzehuropi uye anotungamirira kune zvakashata kushanda. Chimwe chezvinhu izvi zvakasiyana-siyana chinonzi frontotemporal dementia (FTD), chirwere chinokanganisa nechemberi uye nguva dzeropa dzehupfungwa (dziri pamberi nechepasi). Inobata 5 kusvika ku15 kubva muzana yevanhu vane dementia.
Dementia ye Frontotemporal inosanganisira mamiriro maviri akasiyana: chirwere cha Pick uye corticobasal degeneration. Iyo yekare inoratidzwa nezvakawanikwa zvisina kukwana zvinonzi miviri ye Pick, inowanikwa mukati me-neurons yeuropi iyo ine muwandu husingawanzo kana kuti puroteni inonzi tau. Kune mazamu anoita seanobatsira kuitika kwechirwere ichi, asi chikonzero chaicho chinoramba chisingazivikanwi. Chirwere che Pick ndechimwe chisingawanzoitiki chinowanzoitika kuvanhu vane makore 40 kusvika makumi matanhatu.
Kusiyana neizvi, corticobasal degeneration (CBD) inoratidzirwa nekurasikirwa kwee-neurons mu cerebral cortex uye basal ganglia, nzvimbo mbiri dzouropi dzinotsvaga kufunga uye kufamba.
Iyi inrophy inogona kuchinja rumwe rutivi rwomuviri pakutanga, asi sezvo chirwere chinopfuurira, mativi maviri omuviri anogona kuve akabatanidzwa. CBD inogona kutanga kumakore makumi matanhatu.
Ndezvipi Zviratidzo zveDementia yePreotemporal?
Nzvimbo yehuropi inobatwa nehutano hwepamberi hwemotokari inotungamirira kune imwe nzira yezviratidzo.
Ne chirwere cha Pick, unhu hwepakutanga nekuchinja kwekuita kunogona kuitika. Izvi zvinogona kuratidzika sematambudziko mumagariro evanhu nemagariro asinganzwisisiki, kumanikidzwa, kana kusafanira. Kusiyana neizvi, chirwere cheAlzheimer chinowanzoonekwa nekutadza kurasika sechiratidzo chikuru. Vanhu vane chirwere chePikk vanogona kunge vane mafungiro asina kujeka kana kuita sevasingafungi (vasina hanya), uye pangangodaro kune zvinetso zvine chokuita nekutaura (kunonzi aphasia) nekushaya pfungwa. Mukufamba kwenguva, kusava nesimba kana kukanganisa kunogona kuitika. Sezvo mutemo, zviratidzo izvi zvicharamba zvichiwedzera.
Corticobasal degeneration ine zviratidzo zvekuwedzera nekuda kwemigumisiro yebasal ganglia. Izvi zvinogona kukonzera zviratidzo zvakafanana nechirwere chePasinson, kusanganisira kusagadzikana, kufamba kunonoka, uye kusaenzana. Vanhu vane CBD vachakudziridzawo apraxia, iyo kusakwanisa kuita sangano rinokanganisa kunyange zvazvo simba remuviri nekubatana kuripo. Somuenzaniso, mumwe munhu ane CBD anogona kunge asingakwanisi kutevedzera mafambiro ekutsvaira mazino, kusvuta fodya, kuvhara bvudzi, kana kudya muto kubva puni. Matambudziko aya ekupedzisira anoita kuti zvibvirire kufamba. Kutaura kunogona kumira, uye kunetseka kumedza kunogonawo kuitika.
Frontotemporal Dementia uye Migumisiro Yehope
Kurara kwevanhu vane dambudziko rekutsvaga kwema-frontotemporal kunogona kuchinja, uye chaizvoizvo, muenzaniso wekurara uye wakamuka unoshandurwa.
Iko inonzi circadian rhythm inova yakaparadzana kwazvo, ine musanganiswa wezviviri izvi zvinosvika masikati nousiku. Izvi zvinoita sokuti zvinowedzera kunze kwekuchinja kunogona kuitika kana uchigara mune imwe nzvimbo yekubatsira yakaita seimba yevanotarisira. Vanhu vane njodzi vanowanzova nechikamu chekurara chekurara , vachivata nehope uye vachimuka mberi kwekugara.
Kana ichitaridzwa ne electroencephalogram (EEG) , rwiyo rwemauropi europi haruna kujairika: rinonoka panguva yekumuka. Kunyange zvakadaro, zvingave zvakasvibirira kusvika kune chetatu chevanhu, saka haisi muedzo wakakwana kuti uongorore mamiriro acho ezvinhu.
Zvimwe zvinetso zvekurara zvinogona kuitika mukutarisana kwepototemororal kune zvikonzero zvakafanana izvo zvinowanzoitika munharaunda yakawanda, kusanganisira apnea yokurara .
Izvi zvingada kuwedzera kuongororwa uye nehutano hwakakodzera hwehutano, zvichienderana nehutachiona hwepfungwa hunobva kuodementia.
Kuchengetedza uye Kupararira muPatentemporal Dementia
Hapana mishonga chaiyo inogona kunonoka kana kuchinja mararamiro evanhu ava. Kurapa, kusanganisira kushandiswa kwemishonga, kunogona kutarisirwa kuderedza zviratidzo zvakananga, asi zvinosuruvarisa, izvi zvinogona kunge zvisingagoni kupindira. Kuchengetedza kunobatsira, kusanganisira kupa nzvimbo yakachengeteka nehutano hunobatsira hwekubatsira.
Kufanirwa kwepakutanga kwemaonero ekutenda kwemazuva mazhinji kunowanzoshaya urombo, pamwe nedzidzo inofambira mberi uye inotambudza - nekuremara ndeyewo chikamu chinowanzo chezvirwere. Chirwere che Pick chinotungamirira kurufu mukati memakore maviri kusvika kune gumi, kazhinji kubva kune hutachiona (zvakadai sepineumonia kana urinary tract infection), kana chimwe chiitiko chekuremara kwakakomba. Corticobasal degeneration inotevera nguva yakafanana nguva, ichifambira mberi makore anopfuura 6 kusvika ku8 uye inotungamirira kurufu nenzira dzakafanana.
Zvakakosha kuti vatarisiri nevanodikanwa nevanhu vane foreotemporal dementia vanochengetedza ruzivo rwekutsigirwa uye vanowana zororo sezvavanoda. Kuvhiringidza kurara kunogona kuva chikamu chiduku munharaunda yezvimwe zvinetso, asi kuvhiringidza kurara maitiro kunotora mararamiro kune munhu ane hanya nevanochengeta. Saka kubata chirwere chinokanganisa kunogona kubatsirwa nekupindira uye kuderedza mutoro wekutarisira.
Kana iwe ukawana iwe unoda rubatsiro rwekugadzirisa chirwere ichi, unogona kubatsirwa nekubvunzurudza neurologist, uyo anogona kubatsira kuronga kuchengetedza uye kupa kutumira kune zvigadzirwa munharaunda yako.
Sources
Kryger, MH et al . "Mazano Nezviito Zvokurapa Mishonga." Elsevier , 5th edition, p. 1042.
"Sarudza chirwere." PubMed Health . Yakasvika: January 30, 2013.
"NINDS Corticobasal Degeneration Information Page." National Institute of Neurological Disorders uye Stroke . Yakasvika: January 30, 2013.