Olanzapine (Zyprexa) ndeimwe yeboka remishonga mutsva antipsychotic inonzi atypical antipsychotics. Aya marudzi emishonga anoonekwa sechisarudzo chakanaka kune vanhu vane Alzheimer kupfuura mamwe mazera ekurapa anopesychotic. Zvisinei, Zyprexa haibvumirwi neU.S. Food and Drug Administration yekurapa psychosis kune vakwegura vakuru vane dambudziko rekuora mwoyo .
Olanzapine ndeyechikamu chemishonga inonzi psychotropics- zvinodhaka zvinokanganisa pfungwa. Antipsychotic mishonga yemishonga yemapfungwa inobata zviratidzo zvechichimba chekuita schizophrenia zvakadai sokunyengedza, kupisa uye kupengesa .
Ndeapi Atypical Antipsychotic Mishonga?
Atypical antipsychotic drugs zvinodanwa kuti zviparadzanise pakati pezvinonzi antipsychotics idzva uye mamwe maitiro anowanzoitwa antipsychotics (akadai seChlorpromazine (Thorazine) uye haloperidol). Atypical antipsychotic mishonga yakatanga kubudiswa muma1980. Zyprexa yakagamuchirwa neChechi neDrug Administration (FDA) muna 1996.
Atypical antipsychotic mishonga ine misiyano yakasiyana yakasiyana uye yakatengeswa semishonga ine zvishoma zvinokonzerwa neurolo nemigumisiro yakadai seyedzidzo ye extrapyramidal uye yakaderera ye tardive dyskinesia. Atypical antipsychotics inogamuchirwa kuitira kurapa schizophrenia asi yakashandiswawo kune vanhu vane bipolar disorde r uye mukurapwa kwekurwadziwa uye psychosis mukuora mwoyo.
Migumisiro Yechipfuva yeZyprexa
Migumisiro yakajairika inosanganisira:
- Akathisia (manzwiro ekushaya kukwanisa kugara akadzikama)
- Constipation
- Kukurova uye kudarika-sedation
- Hypotension (kuderera kwemuviri weropa)
- Chizutu
- Kuwedzera kwehuwandu
- Nengozi yakawedzerwa yehuwandu hwehuga hwehuga uye chirwere cheshuga
- Dambudziko rekuwa
Zvimwe zvinokonzerwa neurolo madhara zvinosanganisira:
- Zviratidzo zveSpypyramidal - maitiro akaoma, asingabatsiri emusoro, mutsi, maoko, muviri, kana maziso.
- Tardive dyskinesia - kusununguka kunofadza kwemuromo, rurimi, rushaya, kana maziso. Ngozi inowedzera nekushandiswa kwenguva refu.
Administration Options yeZyprexa
Zyprexa mahwendefa anowanikwa semapiritsi anogona kutorwa kamwe chete pazuva, mune simba rinosanganisira 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg uye 20 mg. Mishonga inogona kutorwa pamwe kana pasina kudya. Hapana chiitiko chekuongorora ropa chinodiwa.
Zyprexa inowanikwawo mukugadzirisa kunoputika mumuromo kunosangana nemate, pamwe chete nejoyi yepramuscular (kupfurwa).
Iva nechokwadi chokuti unoverenga mirayiridzo yezvinyorwa zvakajeka. Bvunza pamusoro pechinhu chero chipi zvacho chausina chokwadi nacho nemunhu wemishonga kana chiremba.
Yambiro pamusoro peZyprexa uye Vanhu vane Dementia
Kune ngozi yakawanda yekufa kune vanhu vane dhementia vanotora mishonga yekurapa-iyo inosanganisira Zyprexa. Kutsvakurudza kwakawana kuti vazhinji veavo vafa vaibatanidzwa nemoyo yemuviri (semuenzaniso, mwoyo kusakwanisa) kana zvirwere (semuenzaniso, pneumonia).
Kunyange zvazvo Zyprexa isingagamuchirwi kubata vanhu vakwegura vane chirwere chepfungwa chinokonzerwa nehutementia, dzimwe nguva inorayirwa "off-label" (kwete seinobvumirwa neDFA) nechinangwa chokuderedza zvinetso zvehutano kana psychosis.
Kana chirwere chinorwisa antipychotic chinoshandiswa mumamiriro ezvinhu aya, chinofanira kunge chiri mushure meimwe nzira isiri yemishonga inoedza uye shure kwekusimbisa kuti maitiro anoisa njodzi kumunhu ane dhementia kana kune avo vakavapoteredza, kana kuti paranoia yavo nekunyengedza vari kuvhiringidza zvechokwadi .
Zvimwe Atypical Antipsychotic Mishonga
Zvimwe zvinokonzerwa nemishonga inopesana nemasikirwo inosanganisira zvinotevera:
- Quetiapine (Seroquel)
- Risperidone (Risperdal)
- Ariprazole (Abilify)
Mumwe nomumwe wemishonga iyi ane zvakasiyana-siyana, uye nemigumisiro, munharaunda yevanhu pamwe chete nevaya vane chirwere cheAlzheimer.
General Conclusions
Iyo inowanzozivikanwa kuti kana zvimwe tsvakurudzo zvichidikanwa, kudzivirira- kana kushandiswa nekuchenjerera kuongororwa nachiremba-inonzi kana uchifunga Zyprexa kuvanhu vane dambudziko rekushaya mungozo.
Sources:
Eli Lilly. Zyprexa. Yakasvika paFebruary 27, 2016. http://pi.lilly.com/us/zyprexa-pi.pdf
US National Library of Medicine. Olanzapine. December 12, 2015. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601213.html
-Edited naEsther Heerema, MSW