Genetics 'basa risingazivikanwi zvachose mumhuri dzinotambudzwa
Genetics inowanzoita basa mumarudzi ose ezvirwere zvePasinson . Zvisinei, kunyange zvazvo uine ruzivo rwakananga rwema genetics kunogona kuwedzera njodzi yako yechirwere, hazvireve kuti iwe uchahuwana.
Pakati pe15 kusvika ku25 muzana yevanhu vanogara naPasinson vane nhoroondo yemhuri yemamiriro ezvinhu, kana iri pfupi kana yechipiri-degree.
Kuva nechimwe chezvizvarwa izvi kunokuisa pangozi yakanyanya yePacinson, asi hachiri chivimbiso chokuti iwe uchava nehutano.
Mukutaura, kana iwe une Parkinson, haifaniri kureva kuti mumwe wevana vako kana kuti vana vazukuru vachawana chirwere chacho. Inongova kungoratidza kuti ngozi yavo iri pamusoro peavo vasina nhoroondo yemhuri.
Mukuguma, zviitiko zvakawanda zvePasinson hazvina chikonzero chakazivikanwa (icho chatinotaura sechine idiopathic kana chirwere cheporadic). Nepo kune mafomu anoita seanomhanya mumhuri, idzi nhoroondo yezana shoma yematambudziko - anenge mashanu kusvika ku10 muzana, zvose zvataurwa.
Chimiro cheGenic Mutations Chibatanidzwa naPasinson
Kune marudzi ePasinson ayo anoita seakakanganiswa nehutachiona hunokanganisa hunoenda mumhuri. Isu tinowanzoona izvi nekutanga-kutanga kwemhando dzechirwere umo zviratidzo zvinenge zvichitaridzika kare kudarika mavhareji anoyera makore makumi matanhatu .
Imwe rudzi rwechimiro inoshandiswa mumagetsi inobatanidza nemhuri yepa parkinsonism iri mune izvo zvinonzi SNCA gene . Ichi ndicho chimiro chakabatanidzwa nekugadzirwa kwe alpha-synuclein protein, biomolecule iyo inogona kuita kuti zvive zvisina kunaka mumasero emagetsi. Kunyange zvazvo zvisingawanzovi munharaunda yevanhu vakawanda, SNCA gene mutation yakawanikwa munzvimbo dzinenge mbiri dzezana dzemhuri dzakabatwa naPasinson.
Muna 2004, masayendisiti akawana mhando dzakasiyana-siyana dzekuchinja mumhuri dzakawanda umo maverengi akawanda akabatwa. Izvozvo zvinonzi LRRK2 mutation nhasi inobatanidzwa ne1 kusvika kune maviri muzana yezvimwe zviitiko zvePasinson, zvinowanzokonzera vanhu vechiJudha, Ashkenazi, North African Arab-Berber, kana kuti Basque.
Rimwe shanduko rinosanganisira GBA gene rave richizivikanwa kuti rinokonzera chirwere cheGaucher (chirwere chinokonzerwa nekuputsika, kuneta, kushaya ropa, uye kuwedzera kwechiropa uye spleen). Tsvakurudzo yakabva kare yakaratidza kuti GBA mutation inenge iripo muhuwandu hwevanhu vane Parkinson, vachiratidza kubatana kwepakati pakati pekuchinjwa uye chirwere.
Genetics uye Environmental Factors
Zvimwe zvepakati pezvakatipoteredza zvakakoshawo zvakakonzera kukurudzirwa kwePasinson uye inogona, mune dzimwe nguva, kushanda pamwe chete neine genetics kunokonzera chirwere . Chidzidzo muna 2004 chakaratidza kuti vanhu vaive nekuchinja kweYP2D6 geni uye vakaiswa pachena kune mishonga inouraya kaviri vaigona kuwedzera Parkinson.
Pamusoro pavo, zvinouraya mishonga, zvigadzirwa, zvinokonzera, uye zvimwe zvinodhaka zvakasanganiswa zvakasanganiswa naPasinson. Asi zvinonakidza ndezvokuti avo vakange vane mutambo weCYB2D6 uye vakanga vasingazivikanwi nemishonga inouraya vasati vawanika kuti vari pangozi ipi neipi yepamusoro yekuvandudza chirwere.
Shoko Rinobva
Kunyange zvazvo pangave pasina ruzivo rwakananga kwauri panguva ino, migumisiro yekuongorora mazita evanhu anogona kubatsira mamwe mapurisa ePacinson nekubvumira masayendisiti kuti anzwisise zvirwere izvi nekuvandudza marapirwo matsva. Kunyange zvazvo chisarudzo chekuedza chiri munhu wega, zvinogona kuva zvekubatsira kana mhuri dzakawanda dzakatambudzwa kana iwe uri pangozi yakakonzerwa neukama hwako.
Sources:
> Lesage, S. naBrice, A. "Chirwere chePasinson: kubva kune maitiro ekugadzirwa kwemamiogenic kusvika kumagadzirirwo emagetsi.". Human Molecular Genetics . 2009; 18 (R1): R48-59.
> Stewart, A .; Factor, D .; William J. et al. Zvirwere zvePacinsinson: Kuongororwa uye Clinical Management (2 edition). New York: Demos Medical Publishing; 2008; ISBN-10: 1933864001.