Chirwere chePalinson chinowanikwa apo mamwe masero emasero (ayo anonzi neurons) ari mune imwe chikamu chepfungwa dzako anoramba kushanda zvakanaka kana kufa. Aya neuroni anowanzobudisa ikakemikari yakakosha inonzi dopamine, iyo inobatsira kudzora mishonga yekuita.
Kana iwe usina dopamine yakakwana nokuti idzi neuroni hazvizviiti, haugoni kutungamirira kana kudzora maitiro ako emisidha kazhinji.
Izvozvo ndezvokuti nzvimbo yehuropi yako inovaka idzi dopamine-making neurons (nzvimbo yeuropi inozivikanwa se-substantia nigra) haigone kutumira zviratidzo kune inotevera inonzi "relay station" yeuropi, corpus striatum.
Zvidzidzo zvakaratidza kuti varwere vePasinson vane kurasikirwa kwema80% kana kupfuura kwemasero ekubudisa dopamine mu substantia nigra. Kushayikwa kwedopamine kunokonzera kufamba kwakasimba, kwakasimba kunowanikwa muhosha yaPasinson.
Chii Chinokonzera Kurasikirwa kweDopamine muPasinson?
Masayendisiti haazive kuti sei masero europi mujairo ejairo yechirungu yako inomira kugadzira dopamine, asi pane mazano akawanda.
Genetics inogona kuita mamwe maitiro echirwere chePasinson. Vamwe 15% kusvika 25% yevaya vakaonekwa naPacinson vanewo hama ine chirwere ichi, zvichiratidza kuti zvinokonzerwa nemagetsi. Mukuwedzera, kune mamwe marudzi ehosha yaPasinson iyo inomhanya mumhuri, uye zvimwe zvemajini zvakabatanidzwa zvakaonekwa.
Asi vanhu vazhinji vane chirwere chePasinson havaoneki seine mhuri yakasimba yemamiriro ezvinhu, uye saka vatsvakurudzi vanotarisa kune imwe nzvimbo nekuda kwechikonzero chacho.
Nhema pamusoro pezvikonzero zvinokonzera
Imwe nyanzvi inobatanidza chikonzero chechirwere chePasinson - kuparadzwa kwemasero emirangariro anoita dopamine - inobata kuti masero anenge aparadzwa nekuda kwekushanduka kwechirwere mumuviri.
Radicals yakasununguka haigadzikani, inogona kutyisa mamolekemu akaitwa nemaitiro ezvakagadzirwa mumuviri.
Radicals vakasununguka vanoita nemakomikoro akavakidzana (kunyanya masimbi akadai simbi) mune imwe nzira inonzi oxidation. Kuchengetedza kunofungidzirwa kunokonzera kukanganisa kwemasukisi, kusanganisira neurons. Kazhinji, rusununguko rusununguko rwenharaunda runochengetwa pasi pesimba ne antioxidants, makemikari anochengetedza masero kubva pane izvi zvinokuvadza.
Varwere vane chirwere chePasinson vakawanikwa vachiwedzera huropi hwehuta, kunyanya mu-substantia nigra, uye kuderera kwemazinga e ferritin, puroteni yakawanikwa mumuviri inopoteredza simbi uye inoisunungura, nokudaro ichidzivirira maviri emuviri.
Imwe nyanzvi inosanganisira mishonga inouraya uye zvimwe zvinodhaka. Vamwe masayendisiti vakaratidza kuti chirwere chePasinson chinogona kuitika kana tsvina mumamiriro ezvinhu inoparadza mazuru anoita dopamine. Pane huwandu hwenhefu (1-methyl-4-phenyl-1,2,3,6, -tetrahydropyridine, kana MPTP, imwe chete) inogona kukonzera zviratidzo zvePalinson's disease.
Kusvika ikozvino, hapana tsvakurudzo yakapa uchapupu hwakasimba hwokuti chepfu ndicho chikonzero chechirwere.
Asi imwe nyanzvi inotsanangura kuti chirwere cheParkinson chinoitika apo, nokuda kwezvikonzero zvisingazivikanwi, zvakajairika, zvakasununguka-zvekare zvekare kupfeka dopamine-inogadzira neuron inokurumidza kusvika kune vamwe vanhu.
Iyi nheyo inotsigirwa nepfungwa yokuti tinorasikirwa zvishoma nezvishoma nzira dzinodzivirira neuroni yedu apo isu takura.
Vatsvakurudzi vakawanda vanofunga kuti kuwirirana kwezvinhu izvi zvina - kuipa kwehutachiona , hutachiona hwepanyika, hutachiona hunokonzerwa nemararamiro, uye kukurumidza kukwegura - zvingagone kuratidzwa kuti zvinokonzera chirwere chacho.
Sources:
Parkinson's Disease Foundation. Zvinokonzera chokwadi peji.
Parkinson's Disease Foundation. Zvinhu Zvakatipoteredza uye Parkinson's: Takadzidzei? fact sheet.