Icho chinogona kuwirirana ne lymphoma here?
Paul Langerhans akaberekerwa muBerlin, Germany, munaJuly 25 1847, mwanakomana wechiremba wechiGermany. Akaenda kunodzidzira mishonga sababa vake, wechidiki iye akawana kukosha kunokosha apo achiri chikoro chepasikiri. Kuwanikwa kwake ndiko kwakava kuzivikanwa se epidermal Langerhans masero, ayo ari chinhu chinokosha mumamiriro ezvinhu anozivikanwa seLangerhans cell histiocytosis.
Kuziva Langerhans Dendritic Cells
Langerhans akabatanidzwa mumakwikwi akazaruka akarongwa neBerlin University. Mumwe musayendisiti anonzi Julius Cohnheim akanga atoita nzira yekuona mavhesi achishandisa tsvina yakaisvonaka yegoridhe uye microscopy chiedza.
Achishandisa Cohnheim's gold chloride techniques muna 1868, Langerhans visualized uye akatsanangura chimwe chinhu muganda chakanga chisina kufanana nemamwe masero eganda-akaritsanangura se dendritic nokuti yakanga ine matavi akafanana nemuti; asi akatiwo yakanga isiri-pigmentary. Mune mamwe mazwi, iyo yakanga isina pigment melanin inowanikwa mune mamwe masero anonzi melanocytes, ayo akabatanidzwawo, uye ndiwo masero anonzi melanoma .
Panguva iyoyo, akafananidza iyi iyi isiri-pigmented branching cell yaiva imwe yemhando yekugamuchira kwechiratidzo kuburikidza neganda kune hurongwa hwemitsipa. Anopfuura zana remakore gare gare, masayendisiti aizoziva kuti Langerhans masero eganda ane mabasa anokosha mumuviri wemuviri .
Muna 1973, Dr. Inga Silberberg akawana kuti epidermal Langerhans masero anomiririra "nzvimbo yakanyanya kupfuura yose yezvirwere zvemuviri." Nhasi, Langerhans masero anotorwa sechetsetse yemhuri yemasero eDendritic, uye ndiyo inodzidza zvakanyatsodzidza.
Masoja eLangerhans akawanikwa muganda anofungidzirwa kuita seastigen masero anouya.
Antigens inonyanya kushandiswa kuti 'ma tags' ayo masimba ezvirwere anokwanisa kuziva. Antigen inouya masero (APCs) masero anonyanya kugadzirisa maantigen, achigadzirisa, uye anovaratidza nenzira inokosha kuitira kuti mamwe masero ezvirwere anokwanisa kuziviswa kuvepo kune dzimwe nyika antigen. Nekubatsira kweAAPC, lymphocyte masero eropa ropa anokwanisa kuziva uye kupindura kumakemikari chaiwo uye vamwe vaparadzi.
Zviratidzo zveLangerhans Cell Histiocytosis (LCH)
Langerhans cell cell histiocytosis, kana LCH, inoshandiswa kune izwi rakwegura, "histiocytosis X," asi mazita ose anoonekwa mumabhuku ekurapa. ICH inenge iri boka rezvirwere zvinowanikwa mukukura kusingadzorwi kwemasero e-Langerhans. Izvo zvinogona kuitika kune imwe nguva, kunyange zvisingaonekwi kuvanhu vakuru. Kunyange zvazvo LCH yave ichizivikanwa kwemazana zana, masayendisiti haasati achinzwisisa zvose zvese zvinokonzera.
ICH inowanzobatanidzwa nemunhu mumwe chete kana kuti "akadzingwa" achionekwa munzvimbo dzisina kukwana pfupa rekufungidzirwa-nzvimbo iyo, kana yakagadzirwa, inoratidza kuti pfupa rakatsiviwa ne histiocytes ine nuclei yakagadzirwa nenyuchi.
Histiocytes, yakafanana nama macrophage kana kuti masero eDendritic, masero ezvirwere zvinoparadza zvinhu zvekunze mukuedza kudzivirira muviri kubva kune utachiona.
Aya hetiocytes, pamwe ne lymphocytes, macrophages, uye eosinophils, inogona kupararira anenge nhengo dzose asi kunyanya ganda, lymph nodes, mapapu, thymus, chiropa, spleen, bone marrow, kana central central system.
Ndezvipi Zvine Zvokuita NeLymphoma?
Dzimwe nyanzvi dzinofunga kuti LCH inogona kukura kukura kwemaLangerhans masero anotevera chemotherapy kana radiotherapy yeHodgkin's disease. Ichi chinongova chimwe chezvidzidzo zvakawanda.
Nhamba dzinoverengeka dzeLangerhans 'cell histiocytosis inobatanidza ne malignant lymphoma yakambotaurwa munguva yakapfuura. Nyaya dzakashuma, zvisinei, dzakamboitika nemarignant lymphoma , pamwe nekutevera lymphoma.
ICH inowanzoonekwa kuvana kubva kune imwe kusvika kune yemakore matatu, iyo inogona kutinhira inotyisa, asi yeuka kuti LCH haina kuwanikwa.
Zviratidzo zvinoenderana nenzvimbo dzekubatanidzwa uye chirwere chacho chinongogumira kune imwe nhengo yehurongwa-kungova pfupa, somuenzaniso, munenge hafu yezviitiko. Dzimwe nguva kupindira kwepafupa hakuiti zviratidzo, asi dzimwe nguva apo kunogona kuva nenhamo mune imwe nzvimbo yepafupa. Kubatanidzwa kweganda kunowanikwa munenge makumi mana kubva muzana ematambudziko, uye chiratidzo chinonyanya kugadzirwa cheganda ndeye-eczema-like rash yakafanana nehutachiona hwehutachiona.
ICH inogona kuva yakaoma kufungidzira, asi yeuka kuti kugara uchishanyira chiremba wako uye hurukuro yakasununguka kunowedzera mikana yekuona kana chimwe chinhu chiri kunze kwechajairika.
> Sources:
> Diapedia. The Living Bookbook yeShuga. Paul Langerhans.
> Jaitley S, Saraswathi T. Pathophysiology yeLangerhans Cells. Nhaurwa yeMuromo uye Maxillofacial Pathology: JOMFP . 2012; 16 (2): 239-244.
> Langerhans P. Uber Die Nerven Der Menschlichenhaut. Archives of Pathological Anatomy 1868; 44: 325-37.
> Li X, Deng Q, Li YM. Mhosva yeLangerhans 'Cell Histiocytosis Ichitevera Hodgkin's Disease. Molecular and Clinical Oncology. 2016; 5 (1): 27-30.
> Satter EK, High WA. Cell Langerhans Histiocytosis: Kudzokorora Kwemazano Azvino eHestiocyte Society. Pediatr Dermatol . 2008 May-Jun. 25 (3): 291-5.