Nharo dzekutanga vaRododopa Pakutanga Vs Gare gare muzvirwere zvePacinsinson
Dopamine inonzi neurotransmitter yakachengetwa kubva ku substantia nigra, nzvimbo duku muuropiyo inosviba muhosha yaPasinson . Sezvo dopamine yakasununguka muuropi inotanga kuwira, zviratidzo zvePalinson's disease zvinooneka. Kana dopamine inotsiviwa, zviratidzo zvakawanda zvinovandudza.
Mumwe angafunga, saka, kuti dopamine inofanira kupiwa nokukurumidza sezvinobvira.
Pane dzimwe nzira, asi. Mukuwedzera kune kupa dopamine zvakananga (chirwere chinonzi carbidopa-levodopa), varwere vePalinson vanokwanisa kubatsirwa nekirasi yemishonga inonzi dopamine agonists. Idzi ndidzo madhiragi asiri dopamine asi ane zvimwe zvakafanana pamutambo wenheyo. Vamwe vanachiremba vakambotaura kuti dopamine agonist inofanira kushandiswa kare kare muchirwere chechirwere uye kuti vakwegura bedzi vane varwere vane uwandu hwekuremara vanofanira kupiwa levodopa.
Nharo dzevaRevhi vepakutanga Vashandise muPasinson's Disease
Levodopa ndiyo mishonga inobatsira zvikuru kune kurapa zviratidzo zveParkinson. Izvozvo zvakati, hazvina matambudziko.
Chimwe chekutya kweLevodopa kushandisa ndechokuti inogona kukonzera kufamba kwakanyanya kunonzi dyskinesia . Vanhu vane dyskinesia vane sangano rinopesana riri kunze kwekutonga kwavo. Kunyange zvazvo inoratidzika isinganzwisisiki, zvisinei, vazhinji vane dyskinesia vanosarudza iyo ku parkinsonism, uye zvidzidzo zvinoratidza kuti dyskinesia pakupedzisira haina zvakawanda zvakakanganisa hupenyu hwehupenyu.
Vamwe vatsvakurudzi vakaratidza kuti dopamine inogona kukurumidza kuwedzera chirwere chechirwere ichi patching pamusoro pezviratidzo. Kutsvakurudza kwakawanda hakuna kubatsirana nepfungwa iyi, zvisinei.
Zviratidzo zvingashandura paine dopamine, zvinoreva kuti pane nguva dzenguva iyo kudengenyeka, kusagadzikana, uye kufamba kunononoka kunonyatsodzorwa kupfuura vamwe.
Kune rumwe rutivi, hazvisanzwisisi kuti kuchinja kwacho kunobata sei hupenyu hwehupenyu. Uyezve, vanhu mune mamwe mishonga saiyo dopamine agonist vanogonawo kuguma kuchinja.
Dzimwe nharo dzinotsigira kushandiswa kwekutanga kweLevodopa dzinoti dzichavandudza hupenyu hwehupenyu pakutanga kwechirwere chechirwere, kukosha kwaro kusina kupiwa zvakakwana. Levodopa inodhura zvakanyanya kudarika dopamine agonists.
Makambani ekushandisa zvinodhaka haasisiri kukurudzira kushandiswa kweLevodopa nokuti kune zvakawanda zvakadai maitiro. Mune mamwe mazwi, pane zvikonzero zvemari zvemakambani ekurapa kushandisa kushandiswa kwemamwe, mishonga inodhura inotanga kupera muhosha yaPasinson, pane kuvimba nekare, evodopa yakaedza-uye-yechokwadi, uye izvi zvinogona kukanganisa kusarudzwa kwekurapa vanachiremba.
Nharo Dzinopikisa VaRevhi Vokutanga Vashandise muPasinson's Disease
Vashomanana vachakakavadzana nezvekubudirira kwakanyanya kweLevodopa, uye varwere vose vePasinson vachazopedzisira vachida mushonga uyu. Pano pane dzimwe pfungwa dzinokurudzira kuti uitange gare gare mune chirwere chechirwere, kunyange zvakadaro.
Mishonga inofanirwa kunyoreswa kuburikidza nekufamba kwechirwere. Mune mamwe mazwi, mumwe munhu ane chirwere chePasinson chakatadza uyo anotangwa pa levodopa achada mishonga kuti iwedzere kuwedzerwa sezvo chirwere chavo chinowedzera.
Pakati pese, dopamine's potency ichapera shure kwemakore matatu. Kana huwandu hwemavodopa husingazogadzirisi zviratidzo, chii chimwezve chiripo kuti uende kune? Pasina simba rinoshandiswa pakushandisa mishonga, kuvhiyiwa kunogona kuva ndiyo chete inoshandiswa. Hazvisi nani here kuchengetedza "bundu guru" kwekupedzisira, kana zviratidzo zvakanyanya?
Pamusoro pemigumisiro yevevodopa yakambokurukurwa, pane zvimwe zvinetso zvinganganisa kusanganisira kuwedzera kukura kwekuita basa, psychosis, uye kuderedzwa kwekutora pfungwa. Ichokwadi, zvakadaro, kuti mimwe mishonga yakadai sedopamine agonists inewo migumisiro, yakadai sokuputika, somnolence uye nemapfungwa ehupfungwa, zvakadai sekubhejera kunodhaka.
Muchidimbu, sei iwe ungashandisa "bundu" rako pakutanga, kunyanya apo vatsvakurudzi vekare (kunyange kana vakabva vapesana) vakaratidza kuti zvinogona kuita kuti chirwere ichi chiwedzere? Kunyanya apo iwe unogona kushandisa mishonga ine mishonga inogona kupedza chirwere chirwere ichi, kunze kwekubatsira nezviratidzo?
Pane Mimwe Mishonga Inoshandiswa Pakurwara kwePacinson?
Imwe nzira ingangodaro kutanga mishonga yakadai se monoamine oxidase inhibitor. Chimwe muenzaniso rasagiline, iyo inoratidzika kunge inobatsira zvikuru apo yakatanga kutanga. Zvimwe zvidzidzo zvakatotiwo rasagiline inogona kuderedza kuora kweuropio kuwedzera mukuwedzera kwekutarisa zviratidzo, izvo zvidzidzo izvi zvinopesana zvikuru. Izvi zvakasiyana nedopamine, mune dzimwe dzidzo dzepakutanga dzakaratidza kuti chirwere chinowedzera nemishonga.
Kugadzirisa Kusangana:
Iko maonero maviri aya angayananiswa sei? Pakupedzisira, hakuna rimwe remishonga yemishonga inokodzera munhu wose. Vanhu vakasiyana uye vanoda mishonga yakasiyana-siyana yakagadzirirwa. Imwe nzira ingangodaro inogona kunge iri kutanga kutanga nemishonga yakadai sa rasagiline, inoteverwa nehana yakaderera yevavodopa. Sezvo chirwere ichi chichifambira mberi, dopamine agonist inogona kuwedzerwa, inoteverwa nehuwandu hweevodopa. Asi pakupedzisira, nzira yakanakisisa inogona kusiyanisa zvose zvichienderana nezvido zvemuurwere zvakasiyana uye chiremba anofarira nezvemishonga yakasiyana.
Sources:
Marras C, Lang A, Krahn M, Tomlinson G, Naglie G; Parkinson Study Group. Unhu hwehupenyu muhutano hwePacinson pakutanga: hutachiwana hwe dyskinesias uye motokari yekuchinja. Mov Disord. 2004 Jan; 19 (1): 22-8.
Parkkinen L, O'Sullivan SS, Kuoppamäki M, Collins C, Kallis C, Holton JL, Williams DR, Revesz T, Lees AJ. Ko levodopa inokurumidza kukanganisa chirwere chepachipatara chePalinson? Neurology. 2011 Oct 11; 77 (15): 1420-6.
Vlaar A, Hovestadt A, van Laar T, Bloem BR.Kurapwa kwepakutanga kwePalinson's disease: levodopa inogadziriswa. Pract Neurol. 2011 Jun; 11 (3): 145-52.