Prezcobix (darunavir + cobicistat) inogadziriswa-muzana inosanganisira antiretroviral zvinoshandiswa mukurapa HIV . Izvo zviviri zvinodhaka zvinowanikwa muPrezcobix zvinotengeswa ku Prezista (darunavir) uye Tybost (cobicistat) .
Iyo imwe-piritsi, tablet-formulated inobudisa nyore, kamwe-zuva dosing, pamwe nekobicistat chikamu chinokurudzira nekusimudzira nekujekesa kweplasma ye Prezista mumuviri.
Prezcobix yakabvumirwa neU.S. Food and Drug Administration (FDA) munaJanuary 2015 kune vose vatsva vakuru uye vane ruzivo vane chirwere cheHIV-1.
Fomu
Teteti yakafukidzirwa yefirimu yakavhara firimu, ine 800mg ye darunavir uye 150mg ye cobicistat, inopenya uye yakazara ne "TG" kune rumwe rutivi uye "800" pane imwe.
Dosage
Rimwe pfupa rinotorwa zuva nezuva nechingwa. Prezcobix haigone kushandiswa iri yoga asi inofanira kutorwa pamwe chete kana imwe kana yakawanda inosangana nemishonga inorwisa maitiro eretroviralviral (s).
Mirayiridzo
Usati watanga, varwere vanofanira kuongororwa kuti vaongorore kusarudzwa kwavo kwekusika kwechiremera sezvo Prezcobix inogona kukanganisa kuora (inso) basa, kazhinji mune varwere vanozivikanwa kana vasingazivikanwi kushandiswa kwechirwere chisingaiti. Kana ichitungamirirwa neViread (tenofovir) - mushonga unozivikanwawo kuti unokonzerwa nokuora mwoyo kwevamwe-zvinokurudzirwa kuti varwere vaongorore kushandiswa kwekufungidzirwa kwekusika, urine glucose, uye urine protein.
Inokurudzirwawo kuti varwere-vane ruzivo rwehutano, zvikurukuru avo vakapararira kuHIV protease inhibitors , vanofanirwa kuongorora maitiro ekudzivirira kusati vatanga kutora Prezcobix. Kana kuongorora kwe genotypic kusingawanikwi, Prezcobix inofanira kudzivirirwa kune chero munhu akambotarisana neHIV protease inhibitors.
Nharaunda Dzakabatana
Muchikamu chechitatu III zvidzidzo zvekuchirapa, huwandu hwezvinogona kuitika pamigumisiro yemishonga zvakawanikwa pakushandisa Prezcobix. Zviitiko zvinowanzovhiringidza zvakanyanya, zvakataurwa mu5% kana pasi pevarwere, vaiva:
- Diarrhea
- Nausea
- Mapundu
- Headache
- Marwadzo emudumbu
- Kudzora
Zvinopesana nezvinodhaka
Prezcobix haafaniri kutorwa nemishonga inotevera kana mishonga inowedzera:
- Anti-anginal mishonga: Ranexa
- Anti-arrhythmic mishonga: Multaq
- Anti-cholesterol mishonga: Mevacor, Zocor
- Anti-gout mishonga: Uroxatral
- Anti-hypertension medication: Revatio
- Antipsychotic mishonga: Latuda, Orap
- Kenza mishonga: Camptosar, Campto
- Ergot-ine anti-migraine zvigadzirwa: DHE 45, Ergotrate, Hydergine, Migranal
- Rifampin-based anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- St. John's Wort
Antiretroviral Drug Interactions
Kushandiswa kwePrzcobix nekutevera ma antiretroviral mishonga kunogona kukonzera kana mukurasikirwa kwekurapa kwechirwere ichi pamwe chete kana kuwedzerwa ngozi yezvibereko zvakashata:
- Crixivan (indinavir) haifaniri kutungamirirwa ne Prezcobix.
- Videx (didanosine) inofanira kutorwa kana awa imwe chete kana awa imwe mushure mekutora Prezcobix.
- Intelence (etravirine) haifaniri kutungamirirwa ne Prezcobix.
- Viramune (nevirapine) haifaniri kutungamirirwa na Prezcobix
- Selzentry (maraviroc) inoshandiswa inofanira kuchinjwa kusvika 150mg kaviri zuva rimwe nerimwe kana inotungamirirwa na Prezcobix.
Zvimwe Kuwirirana kana Kufungisisa
- Taurira chiremba wako chero ipi zvayo inozivikanwa kana kuti inenge yafungidzirwa kushaya (inso) mamiriro ezvinhu iwe ungave uine kutanga usati watanga Prezcobix.
- Erectile dysfunction medication (Viagra, Levitra, Cialis) inofanira kushandiswa nekuchenjerera sezvinonzi cobicistat chikamu mu Prezcobix inogona kusimbisa huwandu hwemigumisiro yakaipa, kusanganisira kuvhiringidzika kwezvinhu, hypotension, uye priapism (zvinorwadza, zvakasimbiswa erections). Zvinokurudzirwa kuti Viagra muyero inoderera kusvika kudarika 25mg mumaawa 48; Murairo weLevitra wakaderera kusvika pakuwedzera ma 2.5mg mumaawa makumi manomwe nemaviri, uye Cialis muyero wakaderera kusvika kudarika 10mg mumaawa 72.
Sources:
Bristol-Myers Squibb. "PREZCOBIX - FULL PRESCRIBING INFORMATION." New York, New York