Kurongwa
Evotaz (atazanavir + cobicistat) inonzi yakagadziriswa inosanganiswa nemishonga inoshandiswa mukurapa HIV . Izvo zvikamu zviviri zvechirwere chacho zvinotengeswa seReyataz (atazanavir) uye Tybost (cobicistat) .
I-pill-pill co-formulation inobvumira nyore, kamwe-zuva dosing, pamwe nekobicistat chikamu zvinobudirira "kukusimudzira" uye kuchengetedza kutarisa kwemalasma yaaitzanavir mumuviri.
Evotaz yakagamuchirwa neU.S. Food and Drug Administration (FDA) munaJanuary 2015 kune vose vatsva vane ruzivo uye vane ruzivo vane utachiona hweHIV-1.
Fomu
Ipafura yakafukidzirwa nefirimu yakafukidzirwa, ine 300mg atazanavir uye 150mg cobicistat, inopenya uye yakazara nemazita "3641" kune rumwe rutivi.
Dosage
Rimwe piritsi rinotorwa zuva nezuva nechingwa. Evotaz haigoni kushandiswa iri yoga asi inofanira kutorwa pamwe chete kana imwe kana yakawanda inosangana nemishonga inorwisa maitiro eretroviralviral (s).
Mirayiridzo
Usati watanga, varwere vanofanira kuongororwa kuti vaongorore kusarudzwa kwavo kwekusika kwekusika sezvo Evotaz inogona kukanganisa kuora (mafungiro) basa, kazhinji mune varwere vanozivikanwa kana vasingazivikanwi kushandiswa kwechirwere chisingaiti. Kana ichitungamirirwa neViread (tenofovir ) -chirwere chinogona kukonzera kuora mwoyo kwechirwere kune vamwe-zvinokurudzirwa kuti varwere vayerwe kufungidzirwa kwechirongwa chekusika, urini glucose, uye urine protein.
Inokurudzirwawo kuti varwere-vane ruzivo rwechirwere, kunyanya avo vanobudiswa kuHIV protease inhibitors , vanofanirwa kuongorora maitiro ekudzivirira kusati vasarudzwa Evotaz.
Kana kuongorora kwe genotypic kusingawanikwi, Evotaz inofanira kudziviswa kune ani zvake akarembera kune HIV protease inhibitors.
Nharaunda Dzakabatana
Muchikamu chechitatu III zvidzidzo zvekuchirapa, huwandu hunogona kuve nemigumisiro yemigumisiro yakagadziriswa pakushandisa Evotaz. Zviitiko zvinowanzovhiringidza zvakanyanya, zvinorondedzerwa mu 2% kana pasi pevatsva varapwa, vaiva:
- Jaundice (kuchena kweganda nemeso)
- Ocular icterus (kupenya kwemaziso)
- Mapundu
- Nausea
Zvisingabatsiri zvinokanganisa zvinosanganisira kuneta, kuora musoro, kusuruvara, kurutsa uye kurwadziwa kwepamuviri. Ipi mairo akaonekwawo mune vamwe varwere apo Evotaz yaitungamirirwa neViread (tenofovir), kunyange zvazvo mhaka dzaionekwa sedzoro uye hazvina kukonzera kuregera kurapwa.
Zvinopesana nezvinodhaka
Evotaz haafaniri kutorwa nemishonga inotevera kana mishonga inowedzera:
- Anti-anginal mishonga: Ranexa
- Anti-arrhythmic mishonga: Multaq
- Anti-cholesterol mishonga: Mevacor, Zocor
- Anti-gout mishonga: Uroxatral
- Anti-hypertension medication: Revatio
- Antipsychotic mishonga: Latuda, Orap
- Kenza mishonga: Camptosar, Campto
- Ergot-ine anti-migraine zvigadzirwa: DHE 45, Ergotrate, Hydergine, Migranal
- Rifampin-based anti-tuberculosis mishonga: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Dormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- St. John's Wort
Antiretroviral Drug Interactions
Kushandiswa kweTybost nekutevera ma antiretroviral mishonga kunogona kukonzera kana mukurasikirwa kwekurapa kwechirwere ichi pamwe chete kana kuwedzerwa kwemigumisiro:
- Crixivan (indinavir) haifaniri kutungamirirwa neEvotaz.
- Intelence (etravirine) haifaniri kutungamirirwa neEvotaz.
- Sustiva (efavirenz) haafaniri kutungamirirwa neEvotaz.
- Viramune (nevirapine) haafaniri kutungamirirwa neEvotaz.
- Selzentry (maraviroc) inoshandiswa inofanira kuchinjwa kusvika 150mg kaviri zuva rega kana ichitungamirirwa neEvotaz.
Zvimwe Kuwirirana kana Kufungisisa
- Ratidza chiremba wako chero ipi zvayo inozivikanwa kana kuti inenge yafungidzirwa kuora (mafungiro) mamiriro ako angave nawo usati watanga Evotaz.
- Ratidza chiremba wako chero ipi zvayo inozivikanwa kana kuti inofungidzirwa hepatic (chiropa) mamiriro ezvinhu iwe ungave uine kutanga usati watanga Evotaz, kusanganisira hepatitis A, hepatitis B kana hepatitis C.
- Antacids ane aluminium kana magnesium hydroxide inogona kudzivirira Evotaz kuti irege kunyatsoiswa. Kana iwe uri kushandisa an-over-the-counter antiacid (semuenzaniso Rolaids, Tums, Milk yeMagnesia), inoratidzirwa kuti inotorwa maawa maviri asati apfuura kana mushure mutezo weEvotaz.
- H 2- vasingagamuchiri vanopikisa vanoshandiswa kudzivirira dumbu asidi (seg., Tagamet, Pepcid, Axid, Zantac) inogonawo kudzivisa kushandiswa kweEvotaz. Inoratidzirwa kuti inotorwa pamwe neEvotaz kana, pamwe chete, maawa gumi vasati vasvika kana mushure mutezo weEvotaz.
- Proton pump inhibitors (p., Losec, Prilosec, Prevacid, Nexium, Pariet) inogonawo kubvisa kuwanikwa kweEvotaz. Inoratidzirwa kuti inotorwa kana maawa gumi nemaviri asati apfuura kana mushure mekuita kweEvotaz.
- Erectile dysfunction medication (Viagra, Levitra, Cialis) inofanira kushandiswa nekuchenjerera sezvo Evotaz inogona kukurudzira huwandu hwemigumisiro yakaipa, kusanganisira kuvhiringidzika kunoonekwa, hypotension, uye priapism (zvinorwadza, zvakasimbiswa erections). Zvinokurudzirwa kuti Viagra muyero iwedzere kusvika kudarika 25mg mumaawa 48; Murairo weLevitra unoderedzwa kusvika pakupfuura ma 2.5mg mumaawa 72; uye mizizi yeCialis iri kuderera kusvika kudarika 10mg mumaawa 72.
- Panguva yekubata pamuviri, Evotaz haifaniri kutarirwa panguva yechipiri kana yechitatu yechitatu, kana murwere ane pamuviri ari kutora H2 -reveror antagonist kana Viread (tenofovir) sezvo zvichigona kunge kune ngozi ye kernicterus (inenge isina kuitika inowanikwa muchecheche rakaoma jaundice).
Sources:
Bristol-Myers Squibb. "Evotaz (Atazanvir + cobicistat) - FULL PRESCRIBING INFORMATION." New York, New York; yakasvika musi waFebruary 3, 2015.