Metformin imishonga inowanzorongedzerwa, kunze-label, yekurapa kwePCOS uye yekugadzirisa ovulation. Icho chiri chekirasi yemishonga inovandudza masero emasero kune insulin uye inotarisa shuga yeropa . Imwe nyanzvi yekutsvaga mabhizimusi inoreva kuti FDA haina kubvumidza kushandiswa kwemishonga inonyanya kuenderana nemamiriro iwayo. Muchiitiko ichi, metformin yakagamuchirwa kuitira kurapwa kwechirwere cheshuga asi kwete yePCOS zvakananga.
Iyo Metformin Inoshanda Sei
Nokuti vakadzi vakawanda vane PCOS vanewo insulin yekudzivisa uye chirwere cheshuga, zvinofungidzirwa kuti kurapa insulin kusagadzikana kunogona kuva nemigumisiro kune dzimwe dzisina kukanganiswa kwehomoni dzinobatanidza nemamiriro acho ezvinhu. Nepo vatsvakurudzi vasina chokwadi chechinhu chaiyo, pane humwe uchapupu hunotsigira chirevo ichi: zvimwe zvidzidzo zvakaratidza kuti vakadzi vanotora musanganisi we metformin uye clomid (chirwere chinoshandiswa kuita kuti ovulation muvakadzi vanozorora) vane kupindurwa kwakanaka kumutambo wemishonga kupfuura avo vanotora clomid chete. Vamwe vakadzi vane PCOS, kunyanya avo vane insulin vanopikisa, vanogona kuona nguva dzinowanzoitika kubva pakutora metformin zvakare.
Metformin Dosage
Nhamba dzinenge 1 500 mg kusvika 2,000 mg zuva nezuva dzinofanirwa, zvichienderana nekudzivirira kwechikadzi kwekudzivirira uye zvinokonzerwa nemigumisiro. Vakadzi vazhinji vanotora metformin vanorondedzera kuva nekurwadziwa kwepamuviri, kusuruvara nekururuva-kunyanya nepamusoro pemadhora.
Chiremba anokwanisa kukurudzira zvishoma nezvishoma kuwedzera muyero wako kusvikira wawana miitiro yakatarwa kuti uwedzere kushivirira kwako kumushonga. Vamwe vanachiremba vacharumbidza iyo yakawedzerwa fomu yekubudiswa , zvinoreva kuti chidiki chiduku chemishonga chinosunungurwa zuva rose, panzvimbo yezvose panguva imwechete seine purogiramu yenguva dzose yekuregererwa.
Zvakakosha kutora mishonga yako sezvakataurwa uye rega chiremba wako azive kana uri kutarisana nemamwe matambudziko .
Metformin uye Kutanga Kuberekwa Kuberekwa
Mukuwedzera pakuoma kuve nepamuviri, vakadzi vane PCOS vangave vari panjodzi yekudzivirira pamuviri. Izvi zvinokonzerwa nokusaenzana kwehomoni uye mazinga epamusoro e insulin. Ongororo dzinoverengeka dzakaratidza kuderera kunoshamisa kwepamuviri yekurasikirwa muvakadzi neCPOS vachitora metformin kuenzaniswa nevakadzi vakanga vasina kutora metformin.
Metformin uye Gestational Diabetes
Zvinosuruvarisa, vakadzi vane PCOS vari pangozi yakawanda yekuwedzera gestational chirwere cheshuga (chirwere cheshuga muhutumbi). Kutsvakurudza kunotsigira kushandiswa kwemetrafini yekudzikisa ngozi yegestational chirwere cheshuga muvakadzi vane PCOS.
Kudzivirirwa kweMetformin muKuberekwa Kwepakutanga
Kuziva kuti chirwere ichi chinogona kukubatsira kudzivirira kubva pakuberekwa pamuviri, mubvunzo unotevera unowanzoita nezvekuchengeteka. Zvidzidzo izvi zvinokurudzira: kusvikira ikozvino, metformin haina kubatanidzwa kune chero zvipi zviduku zvakakonzerwa nekuberekwa kana kutakura kushandiswa kwemafupa kana zvichitorwa munguva yekutanga kwemitatu. Maererano nekudzidza kwakabudiswa muHuman Reproduction , vana vakaberekerwa kumadzimai avo vakatora metformin havana kuratidza kusawirirana mukuberekwa kwekuberekwa, kureba, kukura, kana motokari yekusimudzirwa kwevanhu mumwedzi 18 yekutanga yeupenyu vachifananidzwa nevana vechidiki veUnited States.
Kana uri kuronga kuti uve nepamuviri paunotora metformin, iva nechokwadi kuti utaure nachiremba wako zvisati zvaitika pamusoro pezvaanoda iwe kuti uite kana wawana mimba yakanaka yekuedzwa. Kunyange zvazvo metformin iri chirongwa cheB B, zvinoreva kuti yakanyatsochengeteka pakuzvitakura, zvakanakisisa kutaura nemutano wako uye kutevera mirayiridzo yake. Ramba uchifunga, chiremba wese akasiyana, uye ane chirongwa chavo pane izvo zvakakunakira iwe nemwana wako.
Sources:
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> Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. Urefu, uremu, uye motokari yekusimudzirwa kwevanhu mumwedzi 18 yekutanga yeupenyu muna 126 vacheche vakaberekerwa 109 vanaamai vane polycystic ovary syndrome vakagadzirirwa uye akapfuurira metformin kuburikidza nepamuviri. Munhu > chiremba >. 2004; 19 (6): 1323-1330.
> Khattab S, Mohsen IA, Aboul Foutouh I, et al. Zvinogona here kufanana neforformin kuderedza glycemic index yekudya pakuberekwa kudzivirira macrosomia (ROLO kudzidza): > randomized > control trial. BMJ. 2012; 345: e5605.
> Kinnunen TI, Raitanen J, Aittasalo M, Luoto R. Kudzivirira zvakanyanya gestational weight > kuwana-a > kuongorora kwechikwata chechikwata-randomized controlled control. Euro Clinical Nutriti. 2012; 66 (12): 1344-1350.
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Yakarongwa na Angela Grassi, MS, RDN Expert Expert.