Kakawanda, Kudzivirirwa, uye Zviratidzo zveNzira iyi Yechiratidzo yeRituxan
Allergic reactions kuRituxan, inozivikanwawo seMabetra kana Rituximab , inowanzova nemigumisiro yechirwere ichi chinoshandiswa kurapa lymphoma nezvimwe zvirwere. Ndezvipi zviratidzo zvezvinoitika uye zvinopindurwa sei?
Overview
Rituxan inonzi monoclonal antibody drug, zvinoreva kuti inopararira imwe molecule (CD-20) iri pane mamwe masero emunodzi-masero eropa ayo anokonzera lymphomas, asi iyo inokoshawo mune mimwe mimwe mimwe miviri yakawanda yomuviri, yakadai sedhemumatoid arthritis.
Rituximab inoshandiswa kurapwa mune zvisiri Hodgkin's lymphoma (NHL) uye yakaratidzwa kuti iwedzere kupona mune mamwe maitiro evanhu veNHL kusanganisira kupararira kukuru kweB-cell lymphoma uye follicular lymphoma .
Rituximab ine purogiramu shoma yemapuroteni kubva pamashuga. Nokuda kwechikonzero ichi, rituximab inozivikanwa se "chimeric antibody," zvinoreva kuti yakagadzirwa kubva kumativi anobva kumarudzi maviri akasiyana. Kunyange zvazvo izvi zvichikosha kuti mishonga ishande, miviri yedu inotarirwa kuona vatorwa vekunze uye avo vanogona kuuraya uye kutanga maitiro ekudzivirira zvirwere pamusoro pavo. Izvozvo zvinokonzerwa ne-rituximab zvinowanzoita zvinoitika kumapuroteni emakumbo mumushonga.
Pasati rituximab inoshandiswa, iwe ungangodaro wakarapwa nemishonga inoderedza mukana wekuti iwe uchange uine matanho aanoita. Izvi zvinosanganisira Tylenol (acetaminophen) uye Benadryl (diphenhydramine) uye dzimwe nguva steroid mishonga.
Sezvo diphenhydramine inogona kuita kuti iwe ureruke, kazhinji inokurudzirwa kuti uve nemumwe munhu akutya iwe kumba mushure mekunge iwe uchinge waputira.
Zviratidzo nezviratidzo
Zviratidzo zvinowanzoitwa rituximab zvirwere ndezvekuti:
- Fever uye chills - izvi ndizvo zvinowanzoitika uye zvinoitika kuvanhu vakawanda
- Nausea
- Itching
- Mapundu
- Kusuruvara kunotyisa kana kunwisa kubva mumhino
- Kutamba kwemaoko, tsoka kana chiso
- Deredza kuderera kweropa uye chizoro
- Kuputika kwehuro, kufanana nefivha
- Headache
Izvi zvinowanzoitika mukati memaminitsi makumi matatu kusvika kumaawa maviri ekutanga kuvharirwa kwechirwere uye zvinowanzoitika nekwenyuka yekutanga ( inoda kusvika 80 muzana yevarwere inogadzirisa ) uye inowanzove yakaderera nemiganhu inotevera.
Kazhinji, kushanda kwakasimba kunogona kuitika, kusanganisira:
- Matambudziko anopfuuridza
- Heart attack
- Kuve kwekukurumidza kuwira muropa uye kushamiswa.
Mishonga
Kana iwe uine mhinduro pasinei nekutengesa mishonga yawakapiwa iwe, chinhu chokutanga icho mukoti kana chiremba anoita kunonoka kana kumira kuiswa. Kune mamwe maitiro anonzwisa tsitsi, ndizvo zvose zvinogona kudiwa. Mimwe mishonga inogona kugadziriswa kuderedza kana kumira kupindura. Izvi zvinosanganisira acetaminophen, antiallergics, IV saline kana madhiragi kuwedzerwa ropa uye steroid. Munenge vese varwere, mhinduro yacho inogona kudzorwa nokukurumidza nematanho aya. Nokuda kwekuita kwakakomba, zvikwata zvekuchengetedza zvakanyanya zvinogona kuva zvakakodzera-nezviyero zvekuchengetedza uye kuongorora ropa nekufema. Kunyange zvazvo kufa kwakave kwakataurwa kubva mukugadzirisa kwekuita kwepisheni, ivo vanonyanya kushamisika.
Kudzivirira
Maitiro mashomanana anogona kudzivirira kana kuderedza zvinokonzerwa nezvinokonzera zvirwere ne rituximab:
- Premedication. Sezvakataurwa pamusoro apa, iwe uchave uchiri kutora antihistamine mishonga uye steroid musati waiswa.
- Kutanga kuburitsa zvishoma nezvishoma. Izvi zvakakosha zvikuru kwekutanga kwekusanganiswa apo kugadzirisa kunowanzoitika. Kuvhiringidzika kunowanzotanga zvishoma nezvishoma uye mukana wekuputika unowedzera kana pasina kuitika kunoitika.
- Kuchengeta ropa remishonga mishonga vasati vamukira. Sezvo kuwira muropa kunogona kuitika panguva yekudavira, vanachiremba dzimwe nguva vanokurudzira varwere kuti varege kushandisa ropa ravo remishonga mishonga vasati vapera. Iwe unofanira kungoita izvi pasi pemirayiridzo yakananga kubva kuchiremba wako, zvakadaro.
Vaya vave nemoyo munyoro kana kuenzanisa nerituximab vanogona kupiwa mushonga zvishoma nezvishoma uye vanoda kutora matanho ose emishonga inotevera. Vaya vane maitiro akakomba havawanzogadziriswa nemishonga.
Sources:
LaCasce, A., Castells, M., Burstein, M., uye J. Meyerhardt. Kupindira kwemaitiro ekurapa maitiro anonzi monoclonal antibodies anoshandiswa nekenza itachiona. Kusvika pari zvino. Updated 01/08/16. http://www.uptodate.com/contents/infusion-reactions-to-therapeutic-monoclonal-antibodies-used-for-cancer-therapy