Batsiro nemigumisiro yechipfuva yeAromatase Inhibitor yeBear Cancer
Chii chaunoda kuziva pamusoro pezvinobatsira, zviratidzo, nemigumisiro ye Femara (letrozole) yekenza yengamu?
Femara (letrozole) (inowanzosvibiswa sefimara, femarra, uye femera) inodhaka mune imwe nhengo inonzi aromatase inhibitors. Iyi mishonga inovhara kuumbwa kweesrogen yakaitwa mune dzimwe nzvimbo kunze kweiyo mazai. Sezvo estrogen inogona kuita sehuni yekukura kwekenza yemazamu, Femara inobatsira kuderedza ngozi yako yekudzoka kwekenza yepamusoro uye inovandudza mukana wako wekupona.
Kana uri kurarama nemigumisiro inobva pamishonga iyi, iva nechokwadi chekuverenga pamusoro pezvinobatsira zve Femara uye nzira iyo migumisiro yechirwere ichi inogona kutarisirwa.
Rudzi rweMishonga
Femara is antiestrogen, kana kuti aromatase inhibitor. Zvimwe aromatase inhibitors zvinosanganisira Aromasin (exemestane) uye Arimidex (anastrozole.) Femara haisi steroid.
Hormone Therapy for Breast Cancer
Kutsvakurudza kunoratidza kuti kushandisa hormone therapy kune chestro-receptor-positive kenza yemazamu inoderedza ngozi yekudzoka uye inowedzera kupona. Iko kune maviri makuru maitiro ehomoni inorapa vanhu vane kenza yemazamu.
Musati mambomira, mazai mavari anoita chiyero chikuru chestrogen. Kana mazai ako ari kushanda, Tamoxifen inoshandiswa kudzivisa kukwanisa kweesrogen kusunga nekenza masero.
Mushure mekuguma kwemwedzi, ingave yekuguma kwemwedzi, chirwere chokuvhiya kumwedzi, kana mishonga yekuderedza ovarian , chikuru chestrogen mumutumbi ndicho chakakonzerwa nekuparara kwe androgens kune dzimwe nzvimbo dzomuviri.
Aromatase inhibitors inoshandisa kudzivisa izvi zvinoshandura zvinoshandura uyerogens kune estrogen, nokudaro kudzivisa maumbirwo eestrogen.
Iyo Femara Inoshanda Sei Kudzivirira Breast Cancer Kudzoka
Sezvakataurwa, mushure mekuguma kwemwedzi, iyo inonyanya kunobva isrogen mumuviri ndeye iyo inogadzirwa nenzira ye androgens mumafuta mashupu mumuviri.
Izvi uyerogens ("mahomoni" evanhu) anoshandurwa kuva estrogen mune zvakagadziriswa neine enzyme inonzi aromatase. Nokudzivisa chiito chearomatase, kugadzirwa kweserogen kwavharwa. Izvi zvinoita kuti vashoma vasero isrogen iripo mumuviri kuti ikurudzire chero masero echepere emucheche anogara kana kuti ane simba (estrogen receptor-positive mazamu emasepa emvere).
Ko kukosha kwakakosha sei kuderedza dambudziko rekudzoka kwekenza yepamusoro? Zvinoratidzika isu tose tinoziva nezvomumwe munhu aiva nekenza yepazamu yaibatwa asi akawanazve makore kana makumi emakore gare gare. Hatina chokwadi kuti aya masero emukenza anogona kurara kwenguva refu zvakadini, asi kune pfungwa dzekuti sei gare gare zvinowanzoitika sezvakaitwa nekenza shem masero ayo anonyanya kugadzikana kupfuura masero emukenza evhesi. Kudzoka kwemazuva mashoma kunowanzosangana nemararamiro emvere eestrogen receptor-positive, zvichiita kuti kutsvaga nzira dzeAdjuvant dzakadai seFirara dzinokosha zvikuru.
Ikozvino yakakurudzirwa kuti Zometa inotanga panguva imwechete se Femara kune avo vane kenza yepammenopausal yepamu avo vakapedza kuvhiyiwa uye chemotherapy (ona pasi apa).
Kutsvakurudza Kunotiudzei Nezve Femara
Kune vakadzi vane chirwere chesaergen -positive chamuti chepamu, uye vanogamuchira adjuvant chemotherapy, kurapwa ne-aromatase inhibitor inoratidzika kuderedza dambudziko rekudzoka kusvika 50 muzana.
Zvidzidzo zvakatarisa vakadzi vakagamuchira makore mashanu ekurapwa kweTamoxifen, vakawana kuti kushandisa Femara mushure mekunge nguva ino, kunyange kutanga makore mashomanana gare gare, kwakaguma nekuvandudza kupona.
Vakadzi vanova varumeopausal mumakore maviri kusvika ku3 ekutanga paTamoxifen therapy uye vakabva vashandurwa kuva Femara kwemakore mashanu, vakasangana nehuwandu hwekudzoka kupfuura vakadzi vakaramba vachishandisa Tamoxifen voga kwemakore mashanu.
Kune vakadzi vane menopausal pakutanga kwekurapa kwehomoni, pane zvimwe zvinobatsira pakushandisa aromatase inhibitors pakutanga pane kutanga naTamoxifen.
Hazvizivikanwi nguva yakareba yakakwana iyo Femara inoratidza kubatsirwa, mune mamwe mazwi, kuti kana kusashandisa Femara kwenguva inopfuura makore mashanu inobatsira (ona pasi apa.) Taura newe oncologist sezvo nzvimbo ino iri kuchinja maererano Current recommendations.
Ndiani Anogona Kutora Femara
Ichi chiremba ndezvevakadzi vakamboonekwa kuti vane chirwere chetema-receptor-positive. Mukadzi anofanira kunge akapedza kunyanya kurapwa uye ari pakuenda kumwedzi . Vakadzi ve-pre-menopausal vanogona kutora Femara kana mazai avo ari makemikari akadzingwa. Vakadzi vane chirwere chetrogen chisingawaniki nesrogen havangabatsirwi nemutemo uyu.
Maitiro Akasiyana-siyana Maitiro eHomara uye Mamwe Aromatase Inhibitors
Sezvimwe nemimwe mishonga, migumisiro inowanikwa nevakadzi. Zvipembenene zvinowanzovhiringidza zvinopisa zvinopisa uye maronda uye marwadzo akabatana. Kutaura zvazviri, kurwadziwa kwemisungo uye kubatana ndeimwe yezvikonzero zvakakurumbira izvo vanhu vanomira kutora mishonga (ona pasi apa).
Kupisa kunopisa kunowanzoshamisa, kunyange vanhu vanochinja kubva paTamoxifen kusvika kuHomara mushure mekunge vaine postmenopausal (nemhaka yezera, kuvhiyiwa, kana kuvhara maitiro ovarian) inotarisa kuti kupisa kunopisa kunoita kunge kwakanyanya kune Femara pane tamoxifen. Kunyange zvazvo izvi zvikamu zvinokonzera kushungurudza, chero chinhu chinoderedza isrogen mumitumbi yedu chinogona kutungamirira kumatsva anopisa, uye kuderedza isrogen ndiyo nzira yakanakisisa yekuderedza ngozi yekudzokorora. Vamwe vanhu vakaona zvichibatsira "kuratidza" uye kutarisa kupisa kunopisa sechiratidzo chokuti kurapwa kuri kushanda.
Mimwe migumisiro inowanzojairika inosanganisira misoro, kuneta , kuwedzera kufema, nekushaya hope). Dzidza nezvehungwaru dzekushaya hope kune vanorwara nekenza sezvo zvingaderedza kuponesa kwekenza yemazamu, asi nzira dzokurapa dziripo.
Aromatase inhibitors inogonawo kukonzera kurasikirwa kwepfupa kunogona kutungamirira ku osteoporosis , kunyange kushandiswa kushandiswa kwevakadzi neZometa (kukurudzirwa kwakaitwa muna 2017) kunogona kukanganisa izvi (ona pasi apa).
Aromatase inhibitors haisi kuwedzera kuisa kungozi yekuuraya mwoyo nemarwadzo ekurova kwemaitiro tamoxifen asi inobatanidza nematambudziko emwoyo mashoma zvakadai sekusava nemwoyo mwoyo maitiro uye pericarditis (kuvhiringidza kwekamuri yemwoyo)
Nguva Yokufungidzira Kuregerera Kuchivirira
Zvinosuruvarisa, musuru uye majoini aches ndezvakawandisa pamagetsi ekurapa ne Femara. Mune chimwe chidzidzo chikuru, zvakawanikwa kuti 32 muzana yevarwere vakasiya kushandiswa kwechirwere ichi nekuda kwemigumisiro. Inenge 24 kubva muzana yevanhu vakamisa mishonga inokonzerwa nemasumbu uye masangano aches. Zvakakosha kuziva kuti pakati pevaya vakamisa aromatase inhibitor pamusana pemigumisiro, chetatu vakakwanisa kutsungirira imwe yemimwe mishonga muchikwata chemishonga.
Taura nachiremba wako pamusoro pezvaungaita kuti akubatsire kurarisana nejoka uye muscle aches. Mune mimwe miedzo yakarongedzwa yakawanikwa kuti kugadzirisa muviri kwakabatsira zvikuru kupfuura sham inopupurika mukuderedza musimba aches nemhaka yearomatase inhibitors.
Kupisa kunopisa kunogonawo kushungurudza uye kunotarisirwa sezvo mishonga iri kuderedza kugadzirwa kwe estrogen mumuviri wako. Tarisa pfungwa idzi nenzira dzekutarisana nemoto unopisa.
Osteoporosis Prevention
Kushandiswa kwearomatase inhibitors kunowedzera kurasikirwa kwetema uye kwakaratidzwa kuti hakungowedzera ngozi ye osteoporosis asi nhamba yefupa inoputsika pakati pevakadzi vanoshandisa madhiragi aya. Taura nachiremba wako pamusoro pekuongorora kuongorora kwehutano. Iva nechokwadi chokuti uri kuwana vitamin D yakakwana uye calcium. Izvozvi, zvakakwana mavitamini D mazinga muropa rako kana kuti yakabatana nehupombwe hwepabonde, saka taura nachiremba wako pamusoro pekuita kuti uwandu hwe vitamini D huongorwe, uye zvaunogona kuita kana uwandu huri pasi.
Vakawanda veoncologist vanokurudzira kuwana kuongorora kwepfupa reaspiritual apo aromatase inhibitors inotanga, uye inopindirana gare gare.
Kusanganisira Kushandiswa kwevakadzi neZometa uye Bone Loss
Kune avo vanoongororwa vane kenza yemapamenopaopausal yepabonde, oncologists iye zvino anowanzotanga bisphosphonate Zometa (zoledronic acid) panguva imwecheteyo. Zometa haingori kuderedza ngozi yeropa nekurasikirwa uye osteoporosis ne aromatase inhibitors asi inoderedza ngozi yekudzoka zvakare.
Tradeoffs
Izvozvo zvinokonzerwa nemigumisiro yenguva yevakadzi inonyanya kushivirira kana iwe uchiziva kuti ngozi yako yekudzoka yakaderera zvikuru. Vakadzi vakatora Femara mushure memakore mashanu eTamoxifen vaine dambudziko rakanyanya kudarika rekudzoka kune avo vakatora makore mashanu eTamoxifen. Mukuwedzera, nevakadzikadzi, njodzi yako yekenza mutsva mune rimwe ramufu rinopesana isingapfuuri naTamoxifen oga.
Kusarudza Zvido
Tora Femara kamwe kamwe pazuva nemvura. Ichi chirwere hachifaniri kutorwa nechingwa. Edza kuitora panguva yakafanana zuva rega rega, kuchengetedza kunyange huwandu hwezvinodhaka mumutambo wako. Kana iwe uchinge warasikirwa newaiti, usapindira kaviri, ingomirira kusvikira zuva rakatevera uye udzoke zvakare purogiramu yako yemishonga. Usatora ichi chirwere kana iwe uchiri kuenda kumwedzi kana uri nepamuviri.
Inowanikwa se 2.5 mg mapiritsi, zita rechirwere (hapana chiito chinowanikwa), uye chiremba chete.
Ko Femara Inofanira Kushandiswa Kureba Kupfuura Makore 5 Here?
Mazano maererano nehutano hwakakwana hwevakadzikadzi (uye mamwe aromatase inhibitors) vari kukwikwidzana. Pakutanga mazano aive kwemakore mashanu achitevera kurapwa kwekutanga nekuvhiyiwa uye zvichida chemotherapy uye / kana kuti kurapwa kwemaawa asi izvi zvinogona kuchinja.
Nguva Yekudaidza Chiremba Wako
Mamwe matambudziko makuru, zvakadai sechirwere chemwoyo, dzimwe nguva zvinowanzoitika. Zviratidzo zvinofanira kukukurudzira kudana chiremba wako zvinosanganisira kunetseka kufema, kurwadziwa kwepfupa, kurwadziwa kwemakumbo kana kuvhara, kubuda kwechikadzi chisina kujairika, kuputika kweganda , chirwere, kana kushungurudza uye kurutsa.
The Bottom Line
Kana ikashandiswa kutevera kunyanya kwekenza yepabonde (nekuvhiya, uye chemotherapy uye / kana remishonga inonzi radiation), Femara inogona kuderedza ngozi yekudzokorora. Iyo inodzokorora uye zvirwere zvemasastatic, kazhinji, ndicho chikonzero chikuru chekufa kubva kune kenza yemazamu.
Femara inoratidzirwa kumadzimai anonzi menmenopausal kana kuti avo vari premenopausal asi vane chirwere chekuvhara maawa. Migumisiro yakajairika inosanganisira kupisa kunopisa uye musimba aches uye kurwadziwa. Mamwe emigumisiro yakakomba yakadai sekusava nechirwere chepfungwa chepfungwa uye osteoporosis inogonawo kuitika. Nekuwedzera kwe-bisphosphonate therapy, zvisinei, dambudziko rekufa kwemapfupa rinoratidzika kuderedzwa.
Femara inokurudzirwa kwemakore anenge mashanu achitevera kurapwa kukuru, asi zvidzidzo zvenguva ino zvinoratidza kuti kushandiswa kwenguva refu kunogona kukurudzirwa munguva yemberi.
> Sources
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> Hague, R., Shi, J., Schottinger, J., et al. Mwoyo Mumuviri Mushure meAromatase Inhibitor Use. JAMA Oncology . 2 (12): 1590.
> Halsey, E., Xing, M., uye R. Stockley. Kugadziriswa kwezviratidzo zvekubatana zvine chokuita nearomatase inhibitor therapy mumadzimai anonzi postmenopausal ane kenza yemazamu ekutanga-tanga: kuongororwa kwenyaya. Acupuncture in Medicine . 2015. 33: 188-195.
> Henry, N., Azzouz, F., Desta, A. uye al. Zvinyorwa zveAromatase Inhibitor Kuregererwa semagumisiro ekurapa-Emergent Zviratidzo mukutanga-Stage Cancer Breast. Nyaya yeCliniki Oncology . 2012. 30 (9): 936-942.
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