Estrogen uye Progesterone Yakanaka Breast Cancer
Kana iwe wakanga uine chifuva chepamuviri kana chirwere chekenza yemvere (zvichida mastectomy kana lumpectomy), chimwe chezvinhu zvekutanga zvinoitwa ndechokuti uone mamiriro ehommone receptor yemarara yako. Chirongwa cheHormone receptor, uyewo, chakakosha pakusarudza nzira dzakanakisisa dzokurapa dzekenza yako. Ngatitarisei maitiro ekusiyana ehommone, chii chine chakanaka kana chakaipa chinoreva, uye kuti izvi zvinobata sei matanho enyu ekuongorora nekurapa.
Estrogen uye Progesterone Receptor Test
Estrogen uye progesterone receptor miedzo ndeye "biomarker" kuongororwa kunoitwa pamakondomu ose echechi. Izvi zvicharatidzika pamigumo yako yehutano mushure mekupedzisira biopsy uye mushure mekuvhiyiwa. Vanogamuchira vanodzorerwa zvakare kana iwe uchingodzokorora, sezvo inogona kuchinja kana chirwere chichidzoka kana kupararira. Hormone receptors inotsungirirwa nekushandiswa kwekroscope pamushonga webiopsy.
Kunzwisisa Hormone Receptors
Estrogen uye progesterone receptor ndiwo mapuroteni anowanika pamusoro pezamu masero. Estrogen uye progesterone inowanikwa kune izvi zvakagadziriswa (sekuvhara uye kiyi) kuratidza kuti sero rinokura nekuparadzanisa. Zvose mazamu epazamu ane awa anogamuchirwa, asi anowanikwa muzvizhinji zvakanyanya pamasero epabonde emvere anonzi akanaka.
Kuti uvhare zviratidzo zvakagadzirwa apo estrogen kana progesterone inosunga kune idzi zvinogamuchirwa, zvinodiwa kuita chimwe chezvinhu zviviri.
Iwe unogona kuderedza kuwanda kweesrogen mumuviri (kuburikidza nehutachiona hwekuvhara maawa kana usati warega kana kushandisa aromatase inhibitor mushure mekuguma kwemwedzi) kana kudzivisa mukana kuti isrogen iripo mumuviri haigone kusunga neyakagamuchira.
Kukosha kweEstrogen uye Progesterone Mamiriro neChirwere cheBrazil
Kenza kanonzi isrogen (uye / kana progesterone) yakanaka "inotungamirirwa" ne estrogen.
Haasi ose kenza yemavere echando anotungamirirwa ne estrogen. Mimwe mishonga yemazamu ndeyekuti HER2 yakanaka. Nezvikwereti izvi, kukura zvinhu mumutumbi kusungirirwa kune HER2 receptors pamusoro pekenza masero kuti atse kukura kwemarara. Mamwe mapepa emumukomana haavi neapi emagetsi aya uye anotumidzwa se "kanhamba katatu" kanzira.
Mimwe mishonga yepamuviri iyo yose mahomoni receptor akanaka uye HER2 yakanaka. Nezvinokonzera izvi, masero anogona kukurudzirwa kukura neserogen / progesterone kusungira kune estrogen kana progesterone receptors, kana nekukura kwezvinhu zvinosungirirwa kuHER2 receptors. Aya kanzura inogona kutumidzwa se "katatu akanaka" mazamu emukaka. (Dzidza zvakawanda pamusoro pebasa reestrogen mukenza yebonde).
Positive vs Negative Estrogen Status
Chikamu cheEstrogen Receptor positive (ER +) chinoreva kuti estrogen iri kuita kuti tumarara yako ikure, uye kuti kenza inofanira kupindura zvakanaka kumashonga ekuderedza mahomoni. Kana chikamu chacho chiri Estrogen Receptor chakaipa (ER-), ipapo chironda chako hachisi kutungamirirwa ne estrogen, uye zvibereko zvako zvinoda kuongororwa pamwe chete nedzimwe mimwe miedzo, yakadai semamiriro ako eHER2 , kuti uone kunyatsoshanda kurapwa.
Unofanira Kuda Rini Kubva Numerical Score?
Kana yako hormone yeruzhinji yakaongororwa chete seyakashata, zvakanaka kuti ubvunze chiremba wako nhamba inoratidza marati chaiwo.
Kunyange kana nhamba yacho iri yakaderera, kenza inogona kunyatsobatwa nehomoni inorapwa.
Zvikamu zveHormone Receptor Status
Pamushumo wehutano hwako, unogona kuona zvikamu zveHormone Status. Izvi zvinoratidzirwa senhamba pakati pe 0 ne3. Heino nzira yekunzwisisa nhamba:
- 0 haisi mvumo yekuwana yakawanikwa,
- 1 + nhamba duku,
- 2+ inhamba yepakati, uye
- 3+ iyi nhamba yakakura yemakiti.
Iwe unogona kuwanawo nhamba yemasero kunze kwemasero zana akaedzwa zvakanaka kune hormone receptors. Izvi zvakanyorwa sechiverengero pakati pe 0% (kwete magamuchira) uye 100 muzana (masero ose ane receptors).
Kurapa Ongororo yeEstrogen Receptor Yakanaka Breast Cancer
Kana bundu rako riri ER + uye / kana PG +, chirwere chinonzi hormonal chinowanzokurudzirwa.
Kusarudzwa kwemishonga, zvisinei, kunobva pane menopausal yako.
Musati mambomira, mazai mazai anobudisa yakawanda kwazvo yeserogen. Kuchengetedza iyi estrogen kubva pakubatana nekenza masero kuitira kuti ikure, mushonga unonzi selectivegen receptor modulator inoshandiswa. Iyi mishonga, kufanana ne tamoxifen , inonamatira kune reestrogen receptor kuitira kuti estrogen isakwanisa kusunga.
Mushure mekumuka kwemwedzi mamiriro ezvinhu akasiyana. Kune zvakawanda zvishoma eserogen mumuviri. Panzvimbo peivoes mazai anogadzira estrogen, iyo inowanzobva yesrogen mumuviri ndiyo kutendeuka kwe androgens (varume-mahomoni-hormone) muestrogen. Izvi zvinokonzerwa ne enzyme inonzi aromatase. Mishonga inonzi aromatase inhibitors inogona kudzivisa enzyme iyi kuitira kuti estrogen isati yaburitswa, uye haigoni kusungira kenza yemasera kuita kuti ikure.
Pane matatu aromatase inhibitors ikozvino iripo:
- Arimidex (anastrozole)
- Aromasin (exemestane)
- Femara (letrozole)
Aromatase inhibitors dzimwe nguva inogona kushandiswa mumadzimai e-premenopausal mushure mekuvhara maitiro ekurapa. Chokutanga, mishonga inoshandiswa iyo inodzivirira mavha mavari kubva pakuita estrogen. (Imwe nzira, kunyange isiri sarudzo yekutanga, ndeyekubvisa mavha mavari). Zvadaro, mukadzi anogona kuchinjwa kubva kune tamoxifen kune imwe yearomatase inhibitors. Kuita kudaro kunoratidzika kuva nehupenyu husingaperi kune vamwe vakadzi vane kenza yemazamu.
Kune dzimwe mishonga dzemahomoni dzinogona kushandiswa dzimwe nguva. Faslodex (fulvestrant) inosarudza seestrogen receptor pasi-regulator (SERD). Inogona kushandiswa kune vakadzi vane kuwedzera kwekenza yavo pa tamoxifen kana kuti aromatase inhibitor. Mukuwedzera, pane mamwe mahomoni ekurapa kwemasastatic breast cancer anogona kuonekwa kune vamwe vanhu.
Hormone Receptors uye Breast Cancer Kudzoka kana Metastases
Nekutanga-kutanga mazamu emishonga ayo ari estrogen receptor akanaka, mahomoni ekurapa anogona kuderedza kudzokorora nehafu inenge hafu, ingave tamoxifen inoshandiswa kumadzimai e-premenopausal kana aromatase inhibitors anoshandiswa kune avo vari postmenopausal.
Estrogen Receptor Zvakanaka Tumors uye Bisphosphonates
Munguva pfupi yapfuura, bisphosphonates yakawedzerwa pamwe chete ne aromatase inhibitors pamusana pemazera ekutanga postmenopausal mazamu emukondombera ayo anestrogen receptor positive. Apo inoshandiswa pamwe chete ne aromatase inhibitors vanoita sekuti vaderedze njodzi yekudzokorora, kunyanya kupararira kwekenza yepafu kumapfupa.
Kureba Kwokurapa
Munguva yakapfuura, kurapwa ne tamoxifen kana aromatase inhibitor kwaiwanzoenderera kwemakore mashanu. Iko zvino inofunga kuti kushandisa aromatase inhibitor kwemakore anodarika mashanu kunoderedza ngozi yekudzokorora kune vakadzi vane kenza yemazamu avo vanogona kudzoka zvakare. Zvakakosha kutaura nachiremba wako pamusoro pezvino mazano ekureba kwenguva yekurapa mune zvidzidzo zvitsva izvi.
Pasi pepamusoro paHormone Receptor Test with Breast Cancer
Chimiro chemuviri weHormone chikamu chakakosha chekuongororwa kwekenza yebele. Kana chironda chiri estrogen receptor positive (ER +) zvinoreva kuti estrogen "mutyairi" mukukura kwekenza. Saizvozvowo, chirwere chinonzi progesterone receptor positive (PG +) chinotungamirirwa nekuvapo kweprogesterone. Kazhinji, asi kwete nguva dzose, chiremera chichava zvose ER + uye PG + kana ER- uye PG-.
Kune vakadzi vepenopaopausal, kuvhara reestrogen yeestrogen pamasero echepererera ndeyomuitiro unowanzosvika. Kune vakadzi vanotumira vana, vanodzivirira kuumbwa kweesrogen mumakumbo emishonga ne aromatase inhibitors ndiyo nzira inowanzosvika. Kushandisa mishonga yemakemikari kune avo vane mavambo ekutanga isrogen receptor kana progesterone receptor positives inogona kuderedza zvakanyanya ngozi yekudzokorora. Kune vakadzi vane kenza yemasitamende yemasast, mishonga yemakemikari inogona kuwedzera tariro yeupenyu uye kazhinji kuderedza zviratidzo zvechirwere.
> Kwakabva:
> National Cancer Institute. Breast Cancer Treatment (PDQ) -Health Professional Version. Updated 10/13/17. https://www.cancer.gov/types/breast/hp/breast-treatment-pdq