Gonadotropin Releasing Hormone Agonists (GnRH)
Mubvunzo: Chii chinonzi Gonadotropin Releasing Hormone Agonists (GnRH)?
Mhinduro: Gonadotropin yakabudisa hormone agonists (GnRH) inonzi mishonga inoderedza ovulation nekumira kugadzirwa kweestrogen uye progesterone.
Gonadatropin-Releasing Hormone ndiyo hormone inowanzoitika mumuviri. Iyo inosunungurwa ne hypothalamus uye inodzora kusunungurwa kwe follicle stimulating hormone (FSH) uye luteinizing hormone (LH) kubva pamba yepituitary.
Aya mahomoni FSH neHH zvino anokurudzira kugadzirwa kwesterogen uye progesterone mumapapiro emazinga. Ihwo hukama hunozivikanwa sehistori ye hypothalamic pituitary ovarian iyo inodzora kuenda kwako kumwedzi.
Nekuda kweiyi iyi kushanda zvakanaka uye zvichiita kuti ovulation GnRH inofanira kusunungurwa mumutambo wepulsatile. Kana iyi nheyo iri kushanda zvakanaka iwe unenge uine nguva nguva dzose kana iwe usina kutora pamuviri pawakagadzira.
Kirasi yemishonga inonzi GnRH agonist inoshandisa ichi chidimbu chekuchengetedzwa kwemasimba kweGnRH. Mishonga inoguma mukukurudzirwa kunoramba kuripo kweganda repituitary. Pakutanga kunogona kuve nekupfupika kweFSH neLH kusunungurwa asi mushure mokunge kusina kupora kweGnRH kunokonzera kuti chirwere chepituitary chirege kurega kubudisa FSH neLH, iyo inozopedzisira yavhara kubudiswa kwehomoni muvharo.
Ivatatu GnRH agonists inowanzoshandiswa muchipatara tsika ndeiyi:
Lupron- leuprolide
Zoladex- goserelin
Synarel- nafarelin
Leuprolide uye goserelin inoshandiswa nejisi mumayero emasvondo mana kana masvondo gumi nemaviri apo nafarelin inotungamirirwa nepine spray 1-2 nguva zuva nezuva. Vazhinji vakadzi vachabatwa nekudzvinyirira mazai avo nemavhiki mana uye vanenge vakadzi vose vachapera mushure mavhiki masere ekurapa.
Nokuti GnRH inogadzirisa kwenguva pfupi kubvisa mazai ako ekugadzirwa kweesrogen uye progesterone iyi kirasi yemishonga inoshandiswa kurapa zvimwe zviitiko kune vakadzi vanove estrogen uye progesterone vanovimba. Izvi zvinosanganisira:
Endometriosis
Uterine Fibroids
Kutarisira kwekurema kwekuenda kumwedzi kunopa ropa
Yakakura Premenstrual syndrome / Premenstrual dysphoria disorder
Infertility treatment
Panewo humwe uchapupu hunoratidza kuti GnRH agonist inogonawo kubatsira kuchengetedza mavari yevakadzi vane chirwere chekemotherapy yekenza yepese.
Iyi mishonga inonyatsoshanda kurapwa. Zvinosuruvarisa kuti vane zvimwe zvinokonzera migumisiro. Nemhaka yokuti vanodzvinyirira mazai enyu maitiro ehomoni midzi yemigumisiro yeGnRH agonist inomiririra zviratidzo zvekuenda kumwedzi. Iyi migumisiro miviri inosanganisira:
Kupisa kunopisa-kunowanzoparidzirwa mu80% yevakadzi
Vaginal dryness
Yakaderera libido
Headache
Kuneta
Kushushikana kwemashumo
Kupera kwemapfupa emaminetsi emagetsi
Zviri pachena kuti zviratidzo zvemasopaopausal hazvina kufadza asi kunyanya pamusoro pemagumisiro emagetsi ndiko kurasikirwa kwefupa remaminera emagetsi. Nenzira yakawanda kurasikirwa kwepfupa kunodzokororwa mushure mekunge kurapwa kwamira asi mune zvishoma zvevakadzi iko kurasikirwa kwepafupa hakugoni kuwanikwa zvakakwana.
Kuvhara kurasikirwa kwefupa kunobatanidzwa neGnRH kurapwa chiremba wako angangodaro anopa progestin kana kusanganiswa kweesrogen uye progestin.
Izvi zvinozivikanwa sezvekuwedzera remishonga uye yakaratidzwa kuti inoshanda mukudzivirira kuparadzwa kwefupa kunobatanidza nekushandiswa kwakanyanya kweGnRH agonists. Iyo inogonawo kubatsira kuderedza kuoma kwemhepo inopisa zvakare.
Yakavandudzwa naArea Chisholm MD
Magnon N.Gonadotropin rinobudisa hormone agonist: Kuwedzera vistas; Indian Journal Endocrinology Metabolism. 2011 Nov-Dec; 15 (4): 261-267