Mishonga mitsva yapfuura Inofananidzwa nePahara
Apo mishonga mitsva inenge yavapo, ndeyekusava nechokwadi kuti ingaenzanisa sei nekubudirira kune mishonga iyo inenge yavapo. Munyaya yeHetlioz , inotengeswa pasi pezita rinowanzoitwa tasimelteon, zvakakosha kuongorora kubatsira kwayo mukurapa Hasi-24-Hour Sleep-Wake Disorder (Kwete-24) . Inofananidzwa sei ne melatonin , kurapa kwakakwana kwechirwere ichi?
Kutsvakurudza Kuenzaniswa Pakati PeHetlioz naMelatonin
Pakave pasina kliniki yekutsvakurudza miedzo inoenzanisa kushandiswa kweHetlioz uye melatonin mumusoro wepamusoro-kumusoro. IU.S. Food and Drug Administration (FDA) yakabvumirwa Hetlioz inotarisana nemuedzo wakatariswa ne placebo. Izvi zvinoreva kuti Hetlioz, iyo inoshanda pamagamuchiri muuropi ye melatonin, yakanga yakanyatsoshanda mukurapa Hasi-24 pane mapiritsi e placebo. Kubudirira kwahwo hakuna kusvika apa kunofananidzwa zvakajeka nekutora-over-the-counter melatonin, iyo yaimbova iyo yekutarisira kwechiitiko ichi.
Nheyo dzeKurongwa
Mune mirayiridzo yayo yekupedzisira kubva muna 2007, vasati vasvika Hetlioz, American Academy ye Sleep Medicine (AASM) inokurudzira kushandiswa kwe melatonin mukurapa kwevanhu vasiri 24. Kuti ugare wakagadzikana maitiro emasikirini anogadziriswa anokwanisa kutungamirira kumagadzirirwe ekushaya hope uye kuora zvakanyanya , melatonin inogona kunyatsobudirira.
Uku kusimbidzika kunonzi kushandiswa. Mifungo yehope nekumuka mumapofu vanhu inogona kuenzaniswa, kana kudzidziswa, kumasikati emasikati-maitiro.
Izvi zvinogona kuitika nekuderera zvakanyanya kudarika kwe-the-counter melatonin. Zvakakosha kusarudza mutongi anoyevedza anovimbisa hutano uye zvakananga zviri mukati mechigadzirwa.
Muzhinji, madhii maduku (0.3 mg) anogona kushandiswa pakudzidziswa kwevanhu mapofu vane Vasiri 24. Mukuenzanisa, vazhinji vanowedzera michina zvinowanzova 3 mg ye melatonin (kanomwe zvakanyanyodiwa) kana zvimwe. Izvi zvakanyanyisa melatonin zvinogona kuunza mafunguro, kurwisana nezvikomborero uye zvinogona kutungamirira kumigumisiro.
Nguva yenguva ye melatonin dose yakakosha. Inogona kuda rubatsiro rwechiremba wekurara kuti uone kuti chiyero chekuita uye nguva yakakodzera.
Kuongorora Maitiro Okurapa
Iwe unoziva sei kana kurapwa kuri kushanda? Kunze kwekuvandudza zviratidzo, zvinogona kubatsira kutarisa kubudirira kwehutano kune dzimwe nzira dzechinangwa. Zvigaro zvehope uye laboratory zvikamu zve circadian phase markers zvinogona kubatsira.
Zvinonyanya kukosha, kune vanhu vane Vasiri-24 vasina kuporeswa zvachose, kujekeswa kwenguva yakareba kungave kurapa kunobatsira kunobatsira.
Tariro yekutsvaga tsvakurudzo ichaita kuenzanisa kwakananga pakati peHetlioz uye melatonin, asi panguva ino unogona kufunga pamusoro pekurapa kwekurapa nehope yako nyanzvi kuti uone nzira yakanakisisa iwe.
Sources:
Arendt, J et al . "Kubvumirana kwekuvhiringidzika kwekurara-kupera mumurume akaporeswa nemukati wa melatonin." Lancet .
1988; 1: 774-773.
Morgenthaler TI et al . "Ita maitiro emakiriniki kuongororwa uye kurapwa kwe circadian rhythm kurwara kurara: An American Academy of Sleep Medicine inoshuma." Kurara . 2007; 30: 1445-59.
Lewy, AJ et al . "Kuderera, asi kwete kukwirira, maitiro e melatonin akapinza munhu asina ruzivo rwakasununguka munhu ane chirwere chenguva refu." Chronobiology International . 2002; 19: 649-658.
Tzischinsky, O et al . "Kukosha kwekugadzirisa nguva mu melatonin kutungamirirwa nemurume ari bofu." Journal yepineal tsvakurudzo . 1992; 12: 105-108.
Sack, RL et al . "Entrainment yekusununguka-kutamba circadian rhythms ne melatonin mune mapofu vanhu." NEJM .
2000; 343 (15) 1070-1077.
Sack, RL naLeby AJ. "Circadian rhythm kurara kwekurara: zvidzidzo kubva kune mapofu." Kurara Mishonga Ongororo . 2001; 5 (3): 189-206.