Yakaderedza kubatwa kwakabatanidzwa kune zvinodhaka zvinodhaka uye zvinowedzera
Kubatana kwezvinodhaka-zvinodhaka ndizvo zvinowanzovhiringidza kune vose vane HIV nevanachiremba vavo, kunyanya kana munhu achiona nyanzvi dzakawanda kune dzimwe, nyaya dzisiri dzeHIV. Kunyange zvazvo ma pharmita anokwanisa kazhinji kuona maitiro aya kana mitemo ichizadzwa, pane zvimwe zvinhu zvinowanzoshambadzira zvinogona kuvhara nyore pasi pemharapara yemishonga uye, kana zvakatorwa, zvinowedzera kuderedza kushanda kwemishonga yako ye antiretroviral (ARVs).
Vanogona kuita izvi kana kupindira nekudyiwa kwemamwe maARV, kuvhara maitiro ezvimiti kunofanirwa kuderedza mishonga iyi, kana kuita kuti kuwedzerwa kusingadi kuwedzerwa kana kuderera kwemakiromita emishonga eARV. Zvinotoshamisa kuti zvimwe zvezvibereko izvi zuva nezuva, pamusoro pezvimwe zvinhu, asi zvimwe zviyo kana mishonga isiri mishonga yausingafungi kaviri pamusoro pekutora mumamiriro ezvinhu akadai.
Kana iwe uri kuda kutanga antiretroviral therapy , nguva dzose iva nechokwadi chekuudza chiremba wako chero mishonga kana kuwedzera-kusanganisira mishonga kana huwandu hwekuwedzera-iwe unogona kutora. Kana iwe uchitove uri kurapwa uye uri kutora chero chezvinhu zvinotevera zvinopesana nezviratidzo zvako zveARV, taura nachiremba wako. Iwe unogona kukurukura kana kuongororazve mishonga yako dosing purogiramu, kuvhara chigadzirwa chinopesana, kana kuchinja ma ARV, kana zvichidikanwa.
Antacids Tablets uye Suspensions
Magnesium- uye aluminium-ine antacids (yakadai saMaalox, Mylanta, Milk yeMagnesia, Tums) inogona kukanganisa zvironda zvemudumbu kusvika zvakadai sokupindira zvakanyanya pakuwana mamwe maARV.
Nhengo dzakadai sedzi dzinoita kuti dzirambe dzichikanganiswa kwenguva pfupi uye dzinogona kutarisirwa maawa maviri kusvika matanhatu mushure mokunge kana mushure mutezo.
Ma ARVs akawanda anokanganisa nemishonga iyi anosanganisira:
- Aptivus (tipranavir) -take antacid maawa matanhatu musati maawa maviri kana apfuura
- Edurant (rilpivirine) -tora antiacid maawa maviri musati maawa mana kana apfuura
- Rescriptor (delavirdine) -tora antiacid imwe awa maawa asati apera kana maawa maviri mushure
- Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) -tora antiacid maawa maviri mushure mokunge
- Tivicay (dolutegravir) -tora antiacid maawa matanhatu musati maawa maviri kana apfuura
- Triumeq (dolutegravir + ziagen + epivir) -take antiacid maawa matanhatu musati maawa maviri kana
Zvimwe zvinodhaka-kuderedza zvinodhaka seproton pump inhibitors (kureva, Nexium, Prilosec, Losec, Prevacid) zvinoshanda kwenguva yakareba uye zvinogona kuderedza kusveta kwaReyataz (atazanavir) uye Edurant (rilpivirine) nekusvika 78 muzana uye 40 peresenti, zvichienderana. Sezvo zvakadaro, kushandiswa kweproton pump inhibitor kunopesana kuti kushandiswe nema ARV aya chaiwo uye kutarisirwa kwakakodzera kunofanira kutorwa kana uchishandisa vanopikisa H2 seTagamet neZantac, pamwe chete.
Bvunza chiremba wako kuti akurukure kuchinjwa kwedaire uye / kana mishonga kana uchishandisa chero ipi zvayo kana imwe yemakirasi aya emishonga neReyataz kana Edurant.
St. John's Wort
Hypericum perforatum , inozivikanwa zvikuru kunowanikwa muSt John's Wort, isirimi rinotenderera rinotendwa nevamwe kuti rine anti-inflammatory, antiviral, antidipressant, uye antioxidant. Kunyange imwe huru meta-analysis yakagadzirwa muna 2008 yakaratidza kuti mushonga wemishonga unobatsira mukurapa kwekuora mwoyo kwakanyanya, mamwewo maitiro ayo anoramba ari mukukakavara neuchapupu husina kunyatsotsigira kutsigira zvakawanda zvezvirevo.
Apo inoshandiswa mukurumbidzwa kune antiretroviral therapy, St. John's Wort inogona kukanganisa basa re enzyme CYP450 3A4, iyo inoshandisa neo oxidizing molecules yezvinodhaka kuitira kuti inogona kubviswa mumuviri. Kana izvi zvikaitika, sarum drug concentration yeVIH protease inhibitors (PIs) uye isiri nucleoside reverse transcriptase inhibitors (NNRTIs) inogona kuderedzwa zvakanyanya, dzimwe nguva inosvika 82 muzana. Sezvo zvakadaro, St. John's Wort haafaniri kutorwa nemishonga inotevera yeARVs:
- Aptivus (tipranavir)
- Crixivan (indinavir)
- Edurant (rilpivirine)
- Intelence (etravirine)
- Invirase (saquinavir)
- Kaletra (lopinavir + ritonavir)
- Lexiva (fosamprenavir)
- Norvir (ritonavir)
- Prezista (darunavir)
- Rescriptor (delavirdine)
- Reyataz (atazanavir)
- Stribild (iyo inokonzera elvitegravir uye cobicistat zvinodhaka mupiritsi yakabatanidzwa)
- Sustiva (efavirenz) kana Atripla (mushonga unobatanidza une efavirenz)
- Viracept (nelfinavir)
- Viramune (nevirapine)
Garlic
Garlic inotendwa nevamwe kuti vave nezvinhu zvinogona kudzivirira kana kubata zvirwere zvakasiyana-siyana, kubva kunotonhorera uye kuwedzerwa kwepamusoro kweropa kune chirwere chemwoyo chinokonzerwa nekenza. Dzimwe hurumende dzinofunga kuti idzi dzimba kumakemikari ari mugariki inonzi allicin.
Kunyange zvazvo zvidzidzo zvakaratidza kuti zvingave zvakabatsirika zvegarlic supplementation- zvichida muhupfu, kubudiswa, capsule, kana kuti mapiritsi-zvinogona kuva zvipingamupinyi zvakakomba apo inobatanidzwa neprotease inhibitor-class drug Invirase (saquinavir). Nokupindira neCYP450 3A4 mudumbu, garlic zvinowedzera zvinogona kuderedza Invirase serum mishonga yekurapa zvinodarika 54 muzana. Kunyangwe mushure mokugumisa gorozi kushandiswa, zvidzidzo zvakaratidza kuti kudzvinyirira zvinokonzerwa zvinogona kupfuurira kwemazuva uye kunyange masvondo apfuura.
Zvimwe zvidzidzo zvakaratidza kuti gorosi inogonawo kukanganisa kuwanikwa kwezvimwe zvePIs uye NNRTI, kunyange zvazvo pasina zvinopesana zvakananga zvekushandiswa uye pasina mazano pamusoro pekuti yakawanda sei kana marudzi api (anosanganisira yakasvibirira) angave akakodzera kana asina kukodzera. Sezvo zvakadaro, kana uri kutora goriki chero ipi zvayo sekuwedzera kwehutano, inorayirwa kuti iwe urege chiremba wako kurapa azive.
> Sources:
> Dhipatimendi reUnited Health of Health and Human Services (DHHS). "Mirayiridzo yeKushandiswa kweAntiretroviral Agents muHIV-1-Vakabatwa Vakuru Nevana Vari Kuyaruka." Washington, DC; January 19, 2015.
> Linde, K .; Berner, M ;; uye Kriston, L. "St John's wort nokuda kukuru kwekuora mwoyo." Cochrane Database yekuongorora kwakarongeka . Gumiguru 8, 2008; (4): CD000448. doi: 10.1002 / 14651858.CD000448.pub3.
> Piscitelli, S .; Burstein, A .; Welden, N .; et al. "Migumisiro yegariki inowedzera pa pharmacokinetics ye saquinavir." Clinical Infectious Diseases; 34 (2): 234-238.