Utachiona hweHIV hwakagamuchirwa kuKutarirwa kweKutanga-Mutsara wekutanga muUnited States
Tivicay (dolutegravir) inonzi integrase inhibitor -klass antiretroviral drug inoshandiswa mukurapa HIV. Yaiva yechipiri mukirasi ye integrase inhibitors kuti ienderwe neU.S. Food and Drug Administration (FDA).
Tivicay yakapiwa mvumo yeDAA musi waAugust 12, 2013, kuti ishandiswe kune vanhu vakuru uye vana vane makore 12 kana kupfuura vanorema 88 lbs (40kg) uye vasina kumbobvira vatapwa ne integrase inhibitor.
(Tivicay haigamuchirwi nevana vaduku pasi pe12, kunyange zvazvo chirwere chechikamu chechitatu chechipiri chichiri kuitika kuti chiongorore kuchengeteka kwayo uye kubudirira muboka iroro rezera.)
Tivicay inosanganisira chikamu che-once-day, chinogadziriswa-miviri inosanganiswa nemishonga, Triumeq , iyo inosanganisira madhiraki abacavir uye lamivudine. Triumeq yakagamuchirwa neDFA musi waAugust 22, 2014.
Clinical Research Highlights
Zvidzidzo zveVIKING-3 zvakaratidza kuti Tivicay yaive yakabudirira mu 63% yevarwere vakura vanopikisa makirasi akawanda emishonga yeHIV, kusanganisira integrase inhibitors Isentress (ratelgravir) uye elvitegravir (yakawanikwa mune imwe piritsi, inogadziriswa-dose pamwe nemishonga, Stribild ) .
Chidzidzo cheSINGLE chakabudisa pachena kuti varwere veTivicay vaiva nehuwandu hwekuregererwa kwechikonzero pamusana pemigumisiro yakaipa yemishonga kupfuura Atripla (tenofovir + emtricitabine + efavirenz). Mushure memavhiki makumi maviri nemashanu, 2% yezvidzidzo paTivicay-based regimen yakagadzirirwa kurapwa kusvika 10% yevaya vanogamuchira Atripla.
Dosage
- Vakuru: 50mg tablet, kamwe kamwe zuva nezuva
- Vanhu vakuru vane imwe integrase inhibitor-inosangana nokushorwa : 50mg tablet, kaviri zuva rimwe nerimwe
- Vana 12 nepamusoro (kurema 88 lbs / 40kg kana kupfuura): 50mg tablet, kamwe chete zuva rega rega
Uyezve, kune vana vanochengetedzwa pamwe chete naSustiva (efavirenz), Aptivus (tipranavir) + Norvir (ritonavir), Lexiva (fosamprenavir) + Norvir (ritonavir), kana rifampin, chirwere cheTivicay chiri 50mg, kaviri pazuva.
Hazvizivikanwe kana Tivicay inoshanda kune vana vane integrase inhibitor-inosangana nokushorwa.
Drug Administration
Tivicay inogona kutorwa pamwe kana kuti isina kudya, uye chero nguva yezuva.
Nharaunda Dzakabatana
Zvinonyanya kuzivikanwa nemigumisiro yakaipa (inowanikwa mu2% kana pasi pezviitiko) ndeiyi:
- Kunyunyuta
- Headache
- Chizutu
- Nausea
Kubatana kwezvinodhaka kana kusawirirana
Tikosyn (dofetilide), inoshandiswa mukurapa arthmthia (kusagadzikana kwepfungwa), inopesana kuti ishandiswe neTivicay.
Kuti urege kudzivirirwa kushandiswa kwezvinodhaka-zvinodhaka, raira chiremba wako uri kutora chero ipi zvayo inotevera mishonga kana kuwedzera:
- Antiretroviral mishonga: Sustiva (efavirenz), Intelence (etravirine), Viramun (nevirapine), pamwe nekubatanidzwa kweLexiva (fosamprenavir) + Norvir (ritonavir), kana Aptivus (tipranavir) + Norvir (ritonavir)
- Mishonga yekudzivirira-kugunun'una: Trileptal (oxcarbazepine), Dilantin (phenytoin), Phenytek (phenytoin), Luminal (phenobarbital), kana carbamazepine-based drug like Carbatrol, Equetro, Tegretol, Teril, kana Epitol
- Rifampin-based antibiotics: Rifadan, Rifater, Rifamate, Rimactane
- Metformin-based diabetes mishonga: Fortamet, Glucophage, Glumetza, Riomet
- St. John's Wort
Kufunga
- Varwere vanoona zvinokonzera kugadzirisa mushure mokutanga Tivicay vanofanira kuonana nachiremba wavo pakarepo . Mishonga inofanira kumira uye kurapwa kwakatsvaga kana kukanganisa kunoperekedzwa nefivha, musuru kana hutano hunojoka, blisters kana maronda, kuchena kana kuvhara kwemaziso, kuvhara kwechiso kana muromo, kana zvinetso zvokufema. Varwere vakambotarisana ne hypersensitive reaction kuna Tivicay havafaniri kuchinjwa zvakare nemishonga mushure mekugadzirisa zviratidzo.
- Tivicay inofanira kutorwa maawa maviri maawa masere kana masere mushure mekutora antacidum- kana kuti magnesium-ine antacids kana marashi, iron inowedzera, calcium supplements, mishonga inoputika, kana kuti Carafate (sucralfate) inoshandiswa mukurapa kwevodenal ulcers.
- Taurira chiremba wako chero ipi zvayo yechiropa chinogona kuva nacho usati watanga Tivicay. Panogona kuva nehuwandu hwehutambudzo hwechiropa kune vamwe, zvikurukuru kune vanhu vane hepatitis B (HVB), hepatitis C (HCV) , kana kusati kwambovapo kwechiropa. Chiropa chinokonzera chiropa chinofanira kugara chichiongororwa sechikamu chemuitiro wemunhu wepurogiramu yeropa kutora Tivicay.
> Sources:
US National Library of Medicine. "TIVICAY (dolutegravir sodium) tablet, yakafukidzwa." Bethesda, Maryland; yakadzokororwa muna August 2013.
ViiV Healthcare. "ViiV Healthcare inogamuchirwa neDAA yeTurumeq." London, England; press release released 22 August 2014.
Walmsley S .; Antela, A ;; Clumeck, N .; et al. "Dolutegravir (DTG; S / GSK1349572) + abacavir / lamivudine kamwe chete zuva rimwe nerimwe rinotapukira tenofovir / emtricitabine / efavirenz: mhinduro makumi masabata 48 - SINGLE (ING114467)." 52nd Interscience Conference pamusoro peAntimicrobial Agents uye Chemotherapy. San Francisco; Svondo 9-12, 2012; Abstract H-556b.
Nichols, G ;; Grossberg, R .; Lazzarin, A .; et al. "Basa reAntiviral Chiitiko cheDolutegravir mune Zvidzidzo Nekukundikana pane Integrase Inhibitor-Based Regimen: Vhiki 24 Nhamba 3 Zvabuda Kubva VIKING-3." 11th International Congress pamusoro peMishonga Inodhaka muHIV Infection (HIV11). Glasgow, Scotland; November 11-15, 2012; Abstract O232.