Majini ako akakosha, asi zvakadaro zvimwe zvimwe zvinhu
Haisi zvachose chakajeka chinokonzera chirwere chechiliac . Ichokwadi, vazhinji vanotsvakurudza vanotenda kuti zvinhu zvakawanda zvinosanganiswa, izvo zvese zvinogona kudikanwa kuti mamiriro acho awedzere.
Majini ako ane simba rakasimba-kana iwe usina rimwe remamwe majini akange akabatanidzwa nechirwere cheliacac, matambudziko ako ekuvandudza mamiriro acho akadzika (kunyange kwete zero).
Zvisinei, huwandu huwandu hwehuwandu hwevanhu (hunenge 40%) hunotakura imwe chete kana kuti zvose zvemajeni, naizvozvo genetic haisi iyo chete inowanzoita pano.
Kuti uwedzere chirwere ichi, iwe unofanira kunge uchidya gluten . Paunenge uine chirwere chechiliac, gluten inokurudzira muviri wako kuti uparadze hutumbu hwako. Kunyange zvakadaro, gluten inowanzozara muzvokudya zvekuMadokero (vanhu vakawanda vanodya gluten-uye kakawanda kakawanda-kakawanda zuva rimwe nerimwe), uye achiripo chete 1% yevanhu vanokura chirwere ichi.
Pakupedzisira, kuti iwe uve nehutachiona hwechiliac, zvikonzero muhupenyu hwako zvinofanira kubatsira kuburitsa. Ndizvo "zvinhu" izvo zvisiri pachena; Vamwe vanhu vanogona kudya guten zuva rimwe nerimwe kwemakumi emakore pasina dambudziko uye vanobva vatanga zviratidzo zvakanyanya zvechirwere zvirwere zvakangoerekana zvangoitika, apo vamwe vana vaduku vanoratidza zviratidzo zvechiliac pakarepo sezvo mbeu ye gluten inowanikwa muzvokudya zvavo.
Chimwe chidzidzo chinoratidza kuti hutachiwana humwe humwe, mune vamwe vanhu, hunobatsira pakuvandudzwa kwechirwere ichi.
Zvisinei, chidzidzo chacho chinotangira uye kutsvakurudza kwakawanda kunodiwa kuti tinyengedze zvinoitika.
"Tanga" Inogona Kubatsira Kurwisa Dambudziko reCeliac
Vamwe vatsvakurudzi vakafungidzira kuti chirwere chechiliac chinoda "kutama," iyo inogona kutora maitiro ehutano hwehutano kana kunyanya kunetseka mupfungwa; somuenzaniso, vakadzi vakawanda vanotanga kuona zviratidzo zvekurima shure kwekuberekwa nekuberekwa, uye vamwe vanhu vanowana zviratidzo zvavo vanotanga kutevera chirwere chinoratidzika chisingawirirane, kana kutotora nguva inonetsa muupenyu hwavo .
Zvisinei, iyi "nhungamiro" inongoramba isingazivikanwi.
Mamwe masayendisiti anofunga nezvekudya kwema gluten mune zvekudya zvedu-izvo zvakakura zvikuru mumakore makumi mana adarika, zvose sezvatinodya zvimwe zvibereko zvezviyo uye segorosi pachayo inoberekwa kuva nepamusoro-soro yeguten-inogona kukonzera kukonzera mamwe mapepa echiliac. Pane humwe humwe humwe uchapupu hwehutano hwepfungwa iyi, sezvo imwe nguva ichangobva kuongororwa yakawana kuti chiitiko chehosha yeecliac yakapetwa kaviri makore gumi nemashanu kubvira muna 1974.
Vamwewo vari kutarisa chirwere chechiliac pamatokisiki. Kuongororwa kwechangobva kuitika kwakapinda maviri emakemikari-interleukin 15 uye retinoic acid, yakagadzirwa ne vitamin A-sevangangotanga mhinduro yemuviri inopikisa gluten. Vatsvakurudzi vakatarisa vanhu vane chirwere chechiliac vakawana, uye vakawana kuti vaiva nepamusoro ye interleukin 15 mumatumbo avo. Apo vakanyengedza kukwirira kwakakura kwekemikemu imwechete mumakonzo, mbeve dzakagadzira zviratidzo zvekare zvechirwere ichi. Retinoic acid yakawedzera zviratidzo uye kukanganisa.
Apo vatsvakurudzi vakavhara interleukin 15, zvisinei, mutsara yakadzokera kune yakasikwa uye yakakwanisa kutsungirira gluten zvakare. Izvi zvakaita kuti masayendisiti afungisise kuti mazinga makuru e-interleukin 15 mumatumbo ako angakonzera chirwere chechiliac.
(Zvechokwadi, zvichiri pachena kuti chii chingaita kuti mapeji akakwirira e-interleukin 15 akure mumatumbu ako.) Kunyange zvakadaro, kana zvakadaro, mishonga inodzivirira interleukin 15 (iyo inenge iri mumiedzo mu rheumatoid arthritis varwere) inogonawo kubatsira kubata chirwere ichi.
Unogona Kubatana pakati peCeliac naReovirus?
Masayendisiti akacherechedza zvinogona kuwirirana pakati pehutachiona uye chirwere chinonzi reovirus. Reovirus inobata vanhu vakawanda, kazhinji pavanenge vari vacheche, asi inokonzera vashomanana kana kwete zviratidzo. Kudzidza, kwakabudiswa mumagazini yeScience , yakashandisa mhando dzaive dzakakonzerwa kuti dzive dzechirwere ichi.
Vatsvakurudzi vakawana simba rakasimba rekudzivirirwa kwezvirwere mumuviri iwoyo kana vaine hutachiwana uye vakadya zvokudya.
Vatsvakurudzi vakaongorora zvakare vanhu vatove vaongororwa vane chirwere chechiliac, vachitarisa zvakananga kuti ma antibodies kune chirwere ichi. Vakawana zvikamu zvepamusoro zve reovirus antibodies muvanhu vane celiac-maviri kusvika mashanu zvakapfuura kupfuura vanhu vasina mamiriro.
Ichi chidzidzo hachisati chaswedera pedyo nekuratidza reoviruses chikonzero-kana kunyange chirwere-chinonzi cecliac. Vatsvakurudzi vachada kuitisa zvidzidzo zvekare kuti vaone kana chibatanidza chacho chichikwira. Zvisinei, kana reoviruses dzinozoita kuti zvive nekugadzirwa kwezvirwere zvechiliac, zvinogona kuti chirwere chinogona kubatsira kudzivirira vanhu vane majeni.
Chikonzero chezvirwere zveCeliac Hazvisi Zvisina Kujeka, Pasinei Nokutsvakurudza
Nokudaro kuti adimbure, chirwere chechiliac chinokonzerwa ne: kuva nejeni rakarurama, kudya gluten, uye zvichida nemhando yakadaro.
Imwe nyanzvi isiri yakarurama ndiyo yakakurumbira iyo inopomera kukura kwechirwere cheecyac uye kwete-celiac gluten senzwiki pamusoro pegorosi inogadziriswa. Sezvo gorosi rakashandurwa nemajeti haisi pamusika chero upi zvake, haigone kuwedzera kuwedzera .
Zvisinei, sayenzi yezvechiremba haisati yaziva zvakawanda pamusoro pezvimwe zvinokonzera zvinokonzera, kunyange zvazvo izvozvi zvichiita sechikonzero chekuita kuti vamwe vanhu vane "zvakanaka" majini vakure chirwere chechiliac asi vamwe vasingaiti. Ichokwadi, vatsvakurudzi vatangotanga kutsvaga maitiro akasiyana-siyana. Zvichida, zvakare, kuti kune mamwe majeni anobatanidzwa asati aonekwa.
Hapana mubvunzo kuti, kuziva kuti chinokonzera chirwere chechiliac chingabatsira kukurumidzira kukura kwemishonga inotariswa. Alessio Fasano, MD, mutungamiri weYunivhesiti yeManchester yeMucosal Biology Research Center neCent for Celiac Research, inotsanangura kuti kutsvakurudza kune zvinogona kugadzirisa zvakatipoteredza kune chirwere chechiliac zvakakosha zvikuru-kuzivisa zvikonzero zvechirwere chechiliac zvinogona kubatsira kuumba marapirwo echoliac kana kuti kudzivirira mamiriro zvachose.
Sources:
Bouziat R et al. > Reovirus Infection Anotsvaga Kupindura Zvirwere Zvinopesana Nezvokudya Antigens uye Kuvandudzwa kwezvirwere zveCeliac. Sayenzi . 2017 Apr 7; 356 (6333): 44-50.
Catassi C. et al. Nhoroondo yezvematachiona eecliac autoimmunity muboka reU.SA rakatevera kubva muna 1974. Annals of Medicine. October 2010, p. 530-8.
University of Chicago Celiac Disease Center. Zviratidzo.
University of Chicago News. Vanhu uye mutsva vanodzidza kuwedzera kuisa pfungwa pamusana pehosha yeecliac.
University of Maryland School of Medicine News. Yunivhesiti yeMadlands Center yeCeliac Research Inowana Mukana weCeliac Disease iri Kukura.