Kushandisa Zvinodhaka, Kufungisisa, uye Zvinopesana
Epzicom inonzi yakagadzikana inoshandiswa inoshandiswa mukurapa HIV, iyo ine maviri antiretroviral agents , abacavir (Ziagen) pamwe lamivudine (Epivir). Zvose izvi zvinodhaka zvinoratidzirwa se nucleoside reverse transcriptase inhibitors (NRTIs) uye zvinoshanda nekuvhara enzyme inoda kupedzisa kushandiswa kwechirwere cheDNA mune imwe sero inotapukirwa.
Nokuita kudaro, HIV haina kukwanisa kudzokorora uye kupararira kune mamwe masero.
Epzicom yakagamuchirwa kuti ishandiswe kune vanhu vakuru neU.S. Food and Drug Administration (FDA) musi waAugust 2, 2004. Kunze kweU.S., mishonga inotengeswa pasi pezita rekutengesa Kivexa .
Kugadzirwa Kwezvinodhaka
Epzicom inowanikwa mufomu yebhetheni ine 600mg yeabacavir uye 300mg ye lamivudine. Mahwendefa akafukidzirwa mafirimu aya akareba mumashonga, machena, uye ane "GS FC2" kune rumwe rutivi.
Dosages
Rimwe piritsi rimwe nerimwe rinotorwa nemuromo kana kuti pasina zvokudya. Epzicom haisati yatorwa payo uye inofanira kushandiswa mukurapa pamwe chete pamwe chete kana mamwe madhiragi anonzi antiretroviral.
Nharaunda Dzakabatana
Maitiro akawandisa anowanzobatanidzwa ne Epzicom kushandiswa (kunoitika mumapurisa kusvika 9%) anosanganisira:
- Drug hypersensitivity ( ona pasi apa )
- Kunyunyuta
- Kuora mwoyo
- Musoro / migraine
- Chizutu
- Nausea
- Diarrhea
- Mapundu
- Fever
- Marwadzo emudumbu
Zvizhinji zvezviratidzo izvi zvinowanzoguma kwenguva refu kunyange zvazvo vanhu vane zviratidzo zvemishonga inokonzerwa nemishonga inofanirwa kutsvaga kurapwa.
Mishonga yekushandisa zvinodhaka
Drug hypersensitivity dzimwe nguva inoratidzwa nevarwere vanobudiswa kune abacavir-ine mishonga yemishonga uye vanogona kuuraya kana vakasara vasina kutenderwa. Inoratidzirwa neviri kana kupfuura yezvikamu zvishanu zvinotevera:
- Fever
- Mapundu
- Zviratidzo zvezviratidzo (kusuruvara, kurarisa, kurutsa, kurwadziwa mumimba)
- Kuneta, malaise, kuneta, muscular / joint joint
- Zviratidzo zvekuporesa (kusangurudzika kamwe kamwe kwekukanganiswa, kupera kwekufema, kurwadziwa kwehuro)
Zviratidzo zve hypersensitivity zvinowanzoonekwa mukati memavhiki matanhatu ekutanga ekudzivirirwa, kunyange zvazvo zvingatowoneka pane imwe nhanho yekushandisa zvinodhaka. Kazhinji kutaura, zvisinei, zviitiko zvakawanda zvehutachiona hunoitika mukati memazuva gumi ekutanga kana zvakadaro.
Kana kugadziriswa kunofungidzirwa, Epzicom inofanira kumira pakarepo . Varwere vanofanira kuonana zvakare nachiremba wavo uye / kana kuenda kumakiriniki avo ari pedyo kana makamuri ekukurumidzira pasina kunonoka.
Vasati vatanga kurapwa naVaabacavir, vanachiremba vanokurudzirwa kuti vadzivirire HLA-B * 5701 zvakakwana sezvo varwere vane ruzivo rwezvekuberekwa kwechirwere vanozivikanwa sehuwandu hukuru hwebacavir hypersensitivity.
Zvidzidzo zvekuchipatara zvakaratidza kuti vanenge 8% vevarwere pavacavir vachawana hypersensitive reaction, dzimwe nguva yakakomba.
Contraindications
- Pakupedzisira abacavir hypersensitivity: Varwere nerekare hypersensitivity reaction (Ziagen) abacavir havafaniri kuudzwa Epzicom.
- Chiremera chechiropa : Varwere vane hupatic (chiropa) kuora mwoyo vanofanira kudzivisa Epzicom. Ndapota raira chiremba wako kana uine kana unofungidzira kushaya simba kwechiropa, kana kuti wakakonzerwa (kana unofungidzira iwe unenge watapukirwa) ne hepatitis A, hepatitis B, kana hepatitis C. Kuwedzera kwekuwedzera kwehepatitis B kwakataurwa kune vane HIV vane hutano hwakakosha, asi vamwe varwere vane hepatitis C therapies ine interferon uye / kana ribavirin inogona kuwedzera zviratidzo zvinowedzera.
Kubatana Kwemishonga
- Ethanol (kunwa doro): inononoka kubviswa kwavacavir kubva muhurongwa
- Methadone (inoshandiswa mukurapa zvinodhaka zvinodhaka): inoderedza kushanda kwe methadone mune nhamba shomanana yevarwere
Inorayirwa kuti varwere vanodha doro kushandiswa paEpzicom, apo varwere pa methadone vanofanira kurayira chiremba wavo kana Epzicom inorayirwa.
Kurapa Kufungidzirwa
Varwere vane renal (kidyo) kuora mwoyo hakufaniri kupiwa tsamba ye Epzicom kana kubvumirwa kwechiredinine iri pasi pe 50mL / miniti. Mune varwere vane njodzi yekudzivisa kusagadzikana, inosanganisira kuenzaniswa kwechiremera chekusika, serum phosphorus, urini glucose uye urine protein paunenge uchiita maitiro ekuongorora maitiro .
Kunyange zvazvo dzimwe dzidzo dzezvipfuwo dzakaratidza dambudziko rakawanda rekuberekwa kwekuberekwa mumakonzo nemaruva akazarurirwa kuabacavir kana lamivudine, hapana kusiyana kwakadaro kwakataurwa mumadzimai ane pamuviri anonyoreswa kumishonga pamwe nevaya vari vanhu vakawanda.
Munyika yakabudirira, zvinokurudzirwa kuti vanaamai vane HIV vadzivise kunyamwa nekuda kwekuwedzera kungozi yekuendesa HIV kune vacheche.
Sources:
US Food and Drug Administration (FDA). "FDA Inobvumira Zvimwe Zvinokonzerwa-Dose Mikana Drug Products For Treatment of HIV-1 Infection." Silver Spring, Maryland; yakabudiswa musi waAugust 2, 2004.