Chikonzero nei Tine Zvishoma Simba uye Nzira Yokurwa nayo
Chimwe chinhu chinonzi fibromyalgia (FMS) uye chisingagumi kuneta ( syndrome) ( ME / CFS ) yakafanana isisina simba. Izvozvo zvakasiyana nekuneta kana kusava nekukuvadza kunogona kuuya nekuora mwoyo. Tinogona kuda kuita chimwe chinhu asi tisingakwanisi kuzviita.
Chokutanga, hazvisi kufanana nokuve wakaneta uye uchida kurara. Zvakawanda zvepfupa-zvineta, hazvigoni kutamisa manzwiro ekurwadziwa.
Kana iwe wakamboshanda kusvika pakuti iwe haugoni kuita zvakare, zvisinei kuti unodikanwa zvakadini, ndizvo zvatiri kutaurwa. Kana iwe wakambobuda kune aneshesia nemamumbo ako uchinzwa uremera kusimudza, unozviwana. Iwe unogona kunge uchida kurara, asi iwe zvachose unoda kuzorora mishonga yako usati waita chimwe chinhu.
NeFMS ne ME / CFS, kunyange zvakadaro, kushaya simba kunogona kuitika nokukurumidza uye kunopera kwemazuva mazhinji, zvisinei nokuti tinozorora zvakadini. Izvozvo zvinogona kuitika mukati mekufamba kwekutengesa, kubasa, kana kwemaminitsi gumi mushure mokubuda pamubhedha. Zvinogonawo kunge zviripo chinhu chekutanga mangwanani uye kukuchengetedza kubva pakusimuka zvachose.
Isu hatinyatsonzwisisi chiratidzo ichi kana kuti nei ichi chikamu chezvirwere izvi, asi tsvakurudzo inoratidza kuti iri, zvichida muchikamu, nekuda kwepasi mazinga echinhu chinonzi adenosine triphosphate, kana ATP.
Chii Chinonzi Adenosine Triphosphate?
ATP inochengetedza simba mumuviri wako.
Nyanzvi dzezvipenyu dzinowanzoidzaidza kuti "simba rehupenyu hwehupenyu." Ndiyo nyanzvi yekushandisa simba mumasero ese ehupenyu. Ndizvo simba riri muzvokudya zvako rinoshandurwa rikaita kuti rive rinogona kupisa zvose zvomuviri wako.
ATP inobudiswa nemitochondria mumasero ako. Masero ako anouda kuti aite, misumbu yako inodikanwa kuti iite chibvumirano, zvinhu zvose mumuviri wako zvinozvida kuitira kuti zviite sezvinofanirwa.
Adenosine inowanzoitika mumuviri wako uye, pakati pezvimwe zvinhu, inosangana nemutemo wekuyerera kweropa kune dzimwe nhengo dzako. Kana zvasvika kune ATP, kunyange zvakadaro, chikamu chinonzi triphosphate chinonyanya kukosha.
Kuumba ATP, adenosine inobatana nemapoka matatu eepssphates. Apo simba rinodiwa pane imwe nzvimbo uye ATP inotumirwa, imwe yeiyo phosphates inoputswa, kusunungura simba. Zvadaro muviri wako unotsiva phosphate kuti uise zvakare ATP. Icho chigadziriswa kusingaperi.
Apo matongerwo eAATP asina kuwanika mumuviri wako kana chimwe chinhu chinopesana nehuwandu hwekudzorerazve, mazinga eAAT anogona kuve akaderera uye anoita kuti kushaya simba.
Kutadza kweAATP muFibromyalgia
Hatina toni yekutsvakurudza pamusoro pebasa reAATP muFMS, uye zvidzidzo zvatinazvo zviduku. Nenzira yakanaka, dzakanaka chaizvo mukuratidza kuti maAtP maitiro akaderera mumamiriro ezvinhu aya.
Kuongorora kweEurope kwakabudiswa mugore ra2013 kwakaratidza kuwirirana pakati pekuderedza musimba simba mumaoko nemakumbo muFMS uye zvakanyanya kuderera kweAATP uye phosphocreatine, iyo yakafanana nehomwe ye phosphate iyo muviri wako unoshandisa kuchengetedza iyo nzira yekudzokorora ichienda sezvainopisa simba .
Pakutanga basa rakawana zvakawandisa pasi peAATP mumaplatelets evatori vechikamu neFMS pamwe nezvimwe zvinhu zvisina kufanira zvichiratidza kuti mutumbi wakakwanisa kuchengetedza zviyero zvakakwana zveAATP.
Saka kunyange zvazvo muviri webasa uchiratidzika kuti unoona kushayikwa, uye kushayikwa uku kunofungidzirwa kutamba basa mukushaya simba, ndizvo chaizvo zvatinogona kutaura zvino.
Kutadza kweAATP mu ME / CFS
MuMe / CFS, ATP yakagamuchira kunyatsotarisirwa kubva kune vatsvakurudzi, zvichida nekuti kusava nesimba kune zvakanyanya kusiyanisa mu ME / CFS kupfuura muFMS, iyo inowanzotarisa marwadzo.
Zvishoma zvidzidzo zveM ME / CFS zvakatarisa mitochondrial basa mumasero zvakatsigira kutenda kuri kukura kwekuti hutsika hweAtP hwakaderera hunobva pakushata kwemitochondrial, zvichireva kuti zvivako izvozvi zvemasero hazvisi kushanda zvakanaka.
Chimwe chezviratidzo zvinoratidza maMe / CFS ndeye post-exertional malaise , iyo isingaiti uye yakanyanyisa kukura muzviratidzo mushure mekushanda. Kuwanda kwekushingaira kunotora kusiyana nemunhu, asi kunovasiya vasingakwanisi kuita zvakaenzana zvebasa zuva rinotevera, iro risina kujairika uye rakasiyana nehosha iyi.
A 2015 mapepa anogadzirisa post-exertional malaise kuti aite zvakaderera mazinga eATP nekuda kwekushaya kukwana adenosine, zvichiratidza kuti nguva yekurarama kwenguva yakareba iripo nokuti mutumbi unofanirwa kutora pakutanga pane adenosine, uye paAtP.
Chimwe chiitiko chekudzokorora chakabudiswa muna 2014 chinotsigira iyi hypothesis, nevatsvakurudzi vanobatanidza kukanganisa kwekutengesa kweAATP kwete kungotevera post-exertional malaise, asi zvichida kutanga kwechirwere chacho pachavo uye nezvimwe zvipembenene zvisingabatsiri zvinosangana nazvo. Vanyori vepa pepanhau vakatsanangurawo kuti mikana yakaderera yeAATP muna ME / CFS inogona kutungamirira kuzvimoto zvisingakwanisi kuburikidza nekukanganisa pakufa kwemasero.
Kurapa kushaya kweAATP
Mishonga yemishonga inowanzogadziriswa nekuda kwezvirwere izvi haigoni kutarisa zvinogona kuitwa mitochondrial kudzvinyirira kana kushaya ATP. Zvisinei, vamwe vanachiremba vanodzokorora kubudirira nemishonga yekuwedzera inotenda kuti inovandudza matambudziko aya. Zvimwe zveizvi zvinotsigira zvinotsvakurudza kupa zvimwe humwe uchapupu hwekubudirira kwavo.
Iwe unogona kunge wakanzwa nezve coenzyme Q10 (CoQ10) , iyo inowanzoitika mumutumbi wako uye inogona kutorwa sechiwedzera. Inonyanya kuzivikanwa pakati pevanhu vane FMS, ME / CFS, nemamwe mimwe mamiriro ezvinhu, pamwe nehutano hwehutano. Mune chikamu, izvi ndezvokuti muviri wako unoda CoQ10 kuita ATP.
Dzidzo dzinoverengeka dzinosanganisira FMS uye / kana ME / CFS dzinosangana neAtP mazinga akakura neCQ10 inoshaya. Tsvakurudzo dzinoverengeka dzinotiwo CoQ10 inowedzera kuwedzera simba mumamiriro aya. CoQ10 zvinowedzera:
- kuvandudza simba
- kuderedza post-exertional malaise
- kuderedza kuneta
- kununura kurwadziwa kukura (hyperalgesia) yeFMS
Zvimwe zvinotsigira dzimwe nguva zvinoratidzira kuti kushaya simba kwemitochondrial kunosanganisira:
Chiremba wako anogona kukwanisa kurapa dzimwe mishonga yekuwedzera simba rako nekurera mazinga ATP.
Yeuka kuti kunyange zvinhu zvepanyama zvinogona kuva nemigumisiro uye kusawirirana zvisina kunaka nezvimwe zvinhu zvaunotora. Iva nechokwadi chekutaura nachiremba wako pamusoro pemishonga ipi yaunofarira iwe usati watanga, uye iva nechokwadi chokuti unoziva nzira yekuchengetedza zvakakwana regimen yezvekuwedzera .
> Sources:
> Gerdle B, Forsgren MF, Bengtsson A, et al. Kupera kwemafupa ekutengesa kweAATP nePCR mumutambo we quadriceps wevarwere ve fibromyalgia-A 31P-MRS kudzidza. Magazini yeEurope yekurwadziwa. 2013 Sep; 17 (8): 1205-15.
> Lengert N, Drossel B. Muchizivo chesilico yekuongorora kusagadzikana mune myalgic encephalomyelitis / chronic tired fatigue syndrome. Biophysical chemistry. 2015 Jul; 202: 21-31.
> Morris G, Anderston G, Berk M, Maes M. Coenzyme Q10 kupera muhutano uye neuropsychiatric matambudziko: zvinogona kuitika uye zvinoporesa kurapa. Molecular neurobiology. 2013 Dec; 48 (3): 883-903.
> Morris G, Berk M, Galecki P, Maes M. Kubva kunzvimbo yekuzvimirira mu myalgic encephalomyelitis / chronic fatigue syndrome (ME / cfs). Molecular neurobiology. 2014 Apr; 49 (2): 741-56.
> Morris G, Maes M. Mitochondrial dysfunction mu myalgic encephalomyelitis / chronic fatigue syndrome yakatsanangurwa nekugadziriswa maune immune-inflammatory, oxidative uye nitrosative stress pathways. Utachiona hwehutachiona hwemetabolic. 2014 Mar; 29 (1): 19-36.