Chii chinonzi pancytopenia, chii chinoratidza zviratidzo, chii chinokonzera, uye chinoshandiswa sei? Ngatitarisei pamibvunzo iyo.
Pancytopenia inorondedzerwa seasina zvishoma pasi mazinga e marudzi ose emasero eropa anobudiswa nemapfupa emapfupa. Izvi zvinosanganisira masero matsvuku eropa, masero machena, uye maplatelet.
Mishonga Yeropa Inobatwa muPancytopenia
Kunyanya, pancytopenia inoreva kushaya kwe:
- Masero matsvuku eropa (RBCs): RBCs masero anosunga uye anotakura okisijeni kumatumbu emuviri.
- Masoja matsvuku eropa (WBCs): Kune marudzi akawanda emasero matsvuku eropa (WBCs) anowedzera kuputsika mu granulocytes (kusanganisira neutrophils, eosinophils, uye basophils), uye agranulocytes (kusanganisira lymphocytes uye monocytes). Aya masero anokonzera kurwisa zvirwere pakati pemamwe mabasa.
- Platelets: Platelets ane basa rekuvhara ropa.
Achirondedzera Mazinga Atingaiti Majekiseni Eropa
- Nhamba yakaderera yemasero matsvuku eropa inonzi inemia . Zvakakosha kucherechedza kuti pane maitiro akasiyana-siyana ekushaya ropa. Chimwe chinokonzera uwandu hwemasero matsvuku eropa, asi hunogonawo kuitika nekuda kweropa kurasikirwa, hutsika hwe hemoglobin, kushayikwa kwevhitamini B12, nezvimwe zvinokonzera.
- Nhamba yakaderera yemasero matsvuku eropa anonzi se leukopenia (unogona kunzwa nezve neutropenia, iyo inoreva kureba kwemaitiro chaiwo emasero machena anonzi neutrophils).
- Nhamba yakaderera yemaplatelet inonzi inonzi thrombocytopenia, yakadai seopune thrombocytopenia , uye chemotherapy-induced thrombocytopenia .
Kuumbwa Kwemajeri Eropa muPfupa Marrow kana Hematopoiesis
Masero eropa anobva kune imwe chete yerose mumupfu wemafuta anozivikanwa sehematopoietic stem cell (HSM) kana pleuripotential stem masero (zvinoreva kuti ine "simba" rekuve nemhando dzakasiyana dzemasero.
Aya masero akaparadzanisa uye anowedzera zvishoma nezvishoma muitiro anonzi hematopoiesis mune ose masero eropa mumuviri.
Dhiyabhorosi Miedzo
Pancytopenia inowanzoongororwa nekutarisa kuwandisa kwegore rose (CBC). Migumisiro icharatidza kusakwana kwezvikamu zvose zvemasero eropa zvinosanganisira:
- Rimwe sero tsvuku rine ropa risingapfuuri mamiriyoni 4.2 masero / cc kuvakadzi kana pasi pe4,7 Mamiriyoni / cc muvarume (Izvi zvingave zvakare zvinorondedzerwa nehana ye hemoglobin).
- Ropa rega rega riri pasi pe4000 seli / cc (rinowanikwa riri pakati pe 4,000 ne1000 masero / cc).
- Nhamba yeplatelet isiri pasi pe 150,000 seli / cc (inowanzo iri pakati pe 150,000 ne400,000 masero / cc).
Zvinokonzera
Pancytopenia inogona kukonzerwa nechinhu chipi zvacho chinopesana nekuumbwa kwemasero eropa mumapfupa emapfupa kana kuwanika muropa remvura (sekuti kana vakachengetwa mupleen).
Izvi zvinogona kusanganisira mapfupa emapfupa kuparadzwa nemishonga, kupisa kwemasese , zvakadai panguva yechemotherapy, kana kushandiswa kwemafuta emapfupa nedzimwe masero zvinokonzerwa nokuvhiringidzwa kweropa rekugadzirwa kweropa sezvinogona kuitika nemamwe makondombera. Kuparadzwa kana kudzingwa kunogona kuitika kubva pakuvhiringidza , kutapurika, kana mamiriro ezvinhu ega autoimmune .
Mazhinji emamiriro aya anowanikwa gare gare muupenyu, asi vashomanana vanogara nhaka uye varipo kubva pakuberekwa.
Inenge 50 muzana yenguva iyo hapana chikonzero chaicho-chimwe chiremba anotaura se "idiopathic ." Zvimwe zvezvikonzero zvinokonzera pancytopenia zvinogona kusanganisira:
- Chemotherapy-induced bone marrow suppression
- Zvinodhaka-zvinokonzerwa: Zvinodhaka kunze kwekemotherapy zvinodhaka, kubva pamishonga inorwisa mabhakitiriya kusvika kumishonga inoshandiswa nehutano hwepfungwa, zvakataurwa sechikonzero.
- Zvirwere zvakadai sehutachiona hwemotokari neHIV, pamwe nehutachiona hwehutachiona (sepsis).
- Aplastic anemia
- Kugadziriswa kweSplenic (kubata kwemasero eropa mupleen saka haigoni kusvika kune imwe muviri wose).
- Uturu uye makemikari anobudiswa zvakadai sekusvibisa arsenic kana benzene.
- Ropa rekenza mumapfupa emapfupa akadai seaukemia, lymphoma, myeloma, kana kenza yemastasti kuti ifukidze marora.
- Kupararira kwezvimwe zvipembenene zvakasimba kumapfupa emapfupa, kunyanya kenza yemazamu, kenza yeprostate, kenza yemaroni, kenza yemukati, uye melanoma. Nechipfupa chemasera metastases chiratidzo chinowanzozivikanwa chiropafadzo chinokonzerwa ne-thrombocytopenia.
- Myelodysplastic syndrome (a "pre-cancerous" mamiriro emapfupa emapfupa)
- Zvimwe zvinetso zvekuzvidzivirira zvakadai se lupus
- Radiation urwere
- Inherited syndromes, yakadai seFanconi anemia, Diamond Blackfan anemia .
Yakawanda Inowanzokonzera
Chidzidzo chegore cha2014 chakagadziriswa kuti chigadzirise zvikonzero zvinowanzoitika zvepancytopenia kune vanhu vakanga vasati vaongororwa vane chirwere. Somuenzaniso, hapana mumwe wevanhu vakuru ava vakagamuchira chemotherapy kana vane zvikonzero zvakajeka zvepancytopenia yavo. Pakati pevanhu ava:
- Vanopfuura makumi matanhatu kubva muzana vaiva nemhando yekenza yakabatana neropa. Nyaya dzakawanda dzaive dzakawanda dzine myelogenous leukemia , myelodysplasia, isingaiti Hodgkin's lymphoma, ine mvere masero eukemia, uye acute lymphocytic leukemia.
- Pakati peavo vakanga vasina kenza yakagadzikana neropa semhosva ye pancytopenia yavo, zvirwere zvinosanganisira aplastic anemia, megaloblastic anemia, uye HIV. anemia, uye HIV.
Zviratidzo
Zviratidzo zvepancytopenia zvinogona kusanganisira kushaya simba, kugunun'una, kana chirwere chakawedzerwa pane zviratidzo zvine chokuita nekushaikwa kwemasero eropa. Zvimwe zvezviratidzo izvi zvinosanganisira:
- Zviratidzo zvakabatana neanemia (aine tsvuku tsvuku yeropa kuverenga) kusanganisira pallor, kuneta, kukurumidza kwemwoyo, uye kupererwa kwemhepo.
- Zviratidzo zvine chokuita neukopenia kana neutropenia (aine white count) kusanganisira fivha uye zviratidzo zvehutachiona hwakadai sekukanganiswa kana kurwadziwa nekugunzva
- Zviratidzo zvinokonzerwa ne thrombocytopenia (pasi masaplateti) kusanganisira nyore kugunun'una, uye kubuda ropa kunorema.
Kuongorora uye Kuongorora
Mushure mokudzokorora basa renyu rebasa kuti musimbise kuti mune zvechokwadi pancytopenia, danho rekutanga rinowanzova mapfupa emarara.
Mushumo wepafupa wepuropa rinopa chiremba wako ruzivo rwakanyanya.
Kurapa
Chinangwa mukurapa pancytopenia ndechokuwana nekubata chikonzero chinokonzera. Kana chikonzero ichi chisingazivikanwi, kana kana chichitarisirwa, chakadai nekemotherapy, kurapwa kunangwa kugadzirisa zviratidzo zvine chokuita nekushaikwa kwemasero eropa. Mimwe mishonga inogona kushandiswa inosanganisira:
- Zvinodhaka zvinokurudzira marora emapfupa. Kune chemotherapy-induced neutropenia uye zvimwe zvinokonzera, kukura kwezvinhu zvinonzi Leukine, Neupogen, kana Neulasta inogona kushandiswa kusimbisa kuumbwa kwemasero machena eropa. Kune chemotherapy-induced anemia , kunewo mamwe mishonga inogona kuonekwa.
- Kuwedzerwa ropa
- Immunosuppressive drug if it is due to an autoimmune condition.
- Bhuna marora kudururira kana tsvina yesero kutengesa .
Prognosis
Kufanirwa kwepancytopenia kunoenderana zvikuru nemhosva yaro. Tinofara kuti iye zvino tine marapirwo akadai sekuisa ropa uye zvinhu zvinoita kuti tibatsire nehutachiona hwemasero eropa apo mamiriro ezvinhu ari kuongororwa uye kurapwa.
Pasi Pasi
Pane zvakawanda zvinokonzera zvinokonzera pancytopenia, asi zvose zvinotakura ngozi. Ne pancytopenia marudzi ose emasero eropa anoderedzwa, kunyange kuderedzwa mune vamwe kungava kwehanya kune vamwe.
Muenzaniso: Dhani akaumba pancytopenia-yakadzika masero matsvuku eropa, masero emachena eropa, uye maplatelets-mushure mekupedzisira kwechiropiotherapy.
> Sources:
> Devitt, K., Lunde, J., uye M. Lewis. New Onset Pancytopenia muVanhu Vakuru: Ongororo yePathologies Inobatsira uye Tsvakiridzo Yadzo Yakabatanidzwa neIra Laboratory. Leukemia uye Lymphoma . 2014. 55 (5): 1099-105.
> Miano, M., uye C. Dufour. Kuziva nekurapa kweAlastiki Anemia: Kuongorora. International Journal yeHematology . 2015. 101 (6): 527-35.
> Sharma, R., naG. Nalepa. Kuongorora uye Kutungamira kwePanycytopenia Isingaperi. Pediatrics in Review . 2016. 37 (3): 101-113.
> Weinzierl, E., uye D. Arber. Bone Marrow Kuongorora muNew-upt Pancytopenia. Human Pathology . 2013. 44 (6): 1154-64.
> Weinzierl, E., uye D. Arber. The Differential Diagnosis uye Bone Marrow Kuongorora kweNew-onset Pancytopenia. American Journal of Clinical Pathology . 2013. 139 (1): 9-29.