Cytotoxic Chemotherapy uye Dzimwe Cytotoxic Agents
Cytotoxic inoreva chinhu kana chigadzirwa chinokonzera kushandiswa kwesero kana sero rufu. Icho chirevo "cyto" chinoreva sero uye "chekisi" kune chepfu.
Cytotoxic Chemotherapy Zvinodhaka
Kazhinji nguva iyo izwi rokuti "cytotoxic" rinoreva kukanganisa kwemishonga yemakemikrasi ine kenza masero . Nenzira iyi, kemoto inonzi cytotoxic inogona kusiyaniswa kubva kune inonzi cytostatic.
Mishonga ye cytostatic yaizosiyana, inopesana nekuparadzanisa masero uye kukura asi haizomboiti kuti sero kufa zvakananga.
Cytotoxic zvinodhaka zvinoshanda nekuvhiringidza masero pane dzimwe nzvimbo munzvimbo yekukura. Cytotoxic zvinodhaka zvinowanzokonzera masero ari kukura nokukurumidza, somuenzaniso, masero ekenza, mapfupa emveredzi, bone marrow uye masero anovata mudumbu uye mumatumbo. Chikonzero chikuru chemhemotherapy chinoshandisa kusanganiswa kwezvinodhaka uye kuti maitiro akawanda emakemikirini anowirirana ndeokuti makamuri ari munzvimbo dzakasiyana-siyana mukuparadzanisa.
Cytotoxic Agents
Iko kune zvimwe zvinonzi cytotoxic zvinoshandiswa pane zvakasiyana-siyana zvemabasa. Sezvo ne cytotoxic chemotherapy mishonga, izvi zvinongoreva kuti vanouraya masero.
Cytotoxic T cells
Cytotoxic agents haisi kungosikwa kuparadza kenza uye kutarisa zvirwere. Miti yedu inogadzirawo cytotoxic T-seli (cytotoxic T lymphocytes). Cytotoxic T masero inhengo yezvirwere zvemuviri, izvo zvinotsvaga, zvinowana uye zvinoparadza masero anokonzerwa nemavirusi pamwe nemasero ekenza.
Imwe yenzvimbo dzinokurumidza kufambira mberi tsvakurudzo yekenza ikozvino inotarisa kugadzirisa nekusimudzira masero edu e cytotoxic kurwisa kenza mumitumbi yedu.
Cytotoxic Venom
Vanhu havasi ivo voga mukushandisa kwavo ma cytotoxic T masero. Dzimwe zvirwere, zvakadai sezvakabudiswa nenyoka, cobras uye violin spiders, zvakare cytotoxic.
Mechanism of Action
Cytotoxic vashandi vanogona kuuraya masero nenzira dzakawanda. Zvinogona kukuvadza sero kuitira kuti sero yechipfuva isapera uye sero rinoputika (lysis,) kana inogona kupindira nekuparadzaniswa kwemasero kuitira kuti sero rinorega kukura nekuparadzanisa.
Ngozi dzeCytotoxic Zvinodhaka neVashandi
Cytotoxic zvinodhaka zvinogona kuuraya masero emukenza asi zvinogonawo kukuvadza masero, masero ane utano.
Cytotoxic vs Genotoxic
Ikoko kune kupesana kukuru pakati pemashoko anonzi cytotoxic uye genotoxic. Izwi cytotoxic rinoreva kukwanisa kwechimwe chinhu kukonzera kukanganisa kwemasero. Izwi rokuti genotoxic rinoreva kukwanisa kwenyama kunokonzera zvakananga DNA mumasero.
Carcinogenicity / Mutagenicity
Mamwe mashomanana mamwe tsanangudzo anokosha kutsanangura kana achitaura nezve cytotoxicity. Izvi zvinosanganisira:
- Carcinogenic - Kuonekwa kune chinhu chinonzi cytotoxic chinokwanisa kukonzera kukanganisa kweDNA iyo inogona kutungamirira pakuvandudzwa kwekenza.
- Mutagenic - Kujekesa kune cytotoxic zvinhu zvinogona kutyisa ma kromosomes mumucheche.
Ichi ndicho chikonzero chakakosha zvikuru kuti vanhu vashandise kuchenjerera pavanobata cytotoxic zvinodhaka nezvinhu.
Cytotoxic Precautions
Kune avo vanoshanda nemishonga inonzi cytotoxic kana zvimwe zvinhu, matanho anorayirwa zvakananga kuti asave nehutachiona uye mutagenicity.
Izvo zvakanyatsochengetedzwa zvichasiyana zvakanyanya kubva mumugwagwa wekugona kuiswa asi zvinogona kusanganisira:
- Magirafu, ane micheka yakavhara pasi pejasi
- Sleeve yenguvo refu
- Zvishaya nguo
- Magirazi ekudzivirira
- Kudzivirira kupora
Sources:
California Institute of Technology. Mirayiridzo yeKushandiswa kweKytotoxic uye Chemotherapeutic Zvinodhaka. March 2011. https://www.safety.caltech.edu/documents/33-cytotoxic_drugs_guidelines.pdf