Nzira, Chinangwa, uye Matambudziko ePBSCT
Pfupiso yePBSCT
Peripheral blood stem cell transplants, kana PBSCT, ndiyo nzira dzinochengetedza masero emukati ayo akaparadzwa nemaitiro akakwirira emu chemotherapy. Masero emasero masero anomutsa masero eropa - masero matsvuku eropa anotakura okisijeni, masero eropa eropa anobatsira muviri kurwisa zvirwere, uye maplatelets anobatsira kuita ropa.
Yakanga yakashandiswa kuva iyo stem cell transplants yakauya kubva pakugoverwa kwemarara . Kunyange zvazvo akawanda emasero emukati aripo mumasese, mamwe ari kunze ari kubuda - mumharapara yeropa. Izvi zvinogona kuunganidzwa uye zvadaro kuwedzerwa kune varwere kuti vadzorere yavo stem cell kuchengetedzwa. Yakawanda shem cell cell transplants (asi kwete yese nokuda kwezvikonzero zvakawanda) ikozvino PBSCT. Vasati vapa masero emadzimai, vabatsiri vanopiwa mishonga inowedzera huwandu hwemasero emadzipa muropa. Purogiramu ropa remasero emasero rinoshanda zvakanaka kana richienzaniswa nemapfupa emapfupa anoputika, uye chaizvoizvo, pane dzimwe nguva zvinogona kuita kuti maplatelets uye rudzi rwemachena masero eropa anozivikanwa se "neutrophils" kutora "zviri nani, apo mupiro haafambidzani nomugamuchiri .
Chinangwa cheStem Cell Transplants
Kuti unzwisise zvakakwana kuti stem cell transplants inoshanda sei, inogona kubatsira kutaurira zvishoma nezvemasero emasero aripo.
Sezvakataurwa pamusoro apa, masero emadzimai - anonziwo hematopoietic stem masero - anomutsa kune marudzi akasiyana ese eropa mumutumbi. Nokuisa masero emukati anogona kugovera uye kuchinja mumarudzi akasiyana-siyana emasero eropa - chirongwa chinonzi hematopoiesis - kuiswa kunogona kutora kusakwana kwemarudzi ose eropa.
Kusiyana neizvi, kurapwa kwechiremba kunotsiva ose aya masero akaoma uye anotakura matambudziko mazhinji. Semuenzaniso, unogona kupa kuwedzerwa kweplatelet, ropa rekuisira ropa masero, uye kupa mishonga yekukurudzira zvose kuumbwa kwemasero matsvuku eropa uye masero eropa, asi izvi zvakanyanya, zvakaoma, uye ine migumisiro yakawanda uye zvinetso.
Zvikonzero zvePBSCT
Chemotherapy inowanikwa muhotera yakakura inouraya zvirwere zviri nani, asiwo inoparadza masero emadziva aripo mumapfupa emapfupa. Simba rekushandiswa kwemasero rinobatsira kugadzirisa marora emapfupa kuitira kuti murwere anokwanisa kutsungirira maitiro akakwirira emu chemotherapy.
Aina
Kune zvitatu zve stem cell transplant:
- Autologous transplants: apo varwere vanowana mazamu avo emawere.
- Kugadzirwa kweAllogeneic: apo varwere vanowana masero emadzimai kubva kune mukoma wavo, hanzvadzi, kana mubereki. Mumwe mupiki asingabatsiri anogonawo kushandiswa.
- Syngeneic transplants: apo varwere vanowana masero emadzimai kubva kumapatya avo akafanana.
Kupa Peripheral Blood Stem Cells
Mipiro yePBSC inosanganisira kutengesa masero emagazi eropa, pane masero anobva mumapfupa emasese, saka hapana marwadzo kubva pakuwana mafupa. Asi muPBSC, mishonga inopiwa kukurudzira nhamba yemasero emasero mukupararira kwevabatsiri inogona kusanganiswa nemuviri aches, musasa aches, misoro yepamusoro, uye zviratidzo zvakadai semvura.
Izvi zvinowanzova nemisi mazuva mashomanana mushure mekupedzisira kwemaitiro ekudzivirira-masero.
Matambudziko ePBSCT
Kune dzakawanda zvinetso zvinogoneka zvePBSCT. Iko yakakura yemishonga inonzi chemotherapy musati yatorwa inoisa njodzi yakakomba yehutachiona nekuda kwekushayikwa kwemasero matsvuku eropa (immunosuppression) pamwe nezvinetso zvine chokuita nokushaikwa kwemasero matsvuku eropa (anemia) uye pasi platelets (thrombocytopenia.)
Kungozi inowanzoitika mushure mekushandura ndeyeyekubatanidza nekubatana nechirwere (GvH), iyo inowira kune imwe dhigiri munharaunda yese ye stem cell transplants. Mune zvirwere zveGvH zvinoshandiswa masero (kubva kune anopa) vanoziva mutambi (uyo anogamuchirwa mutambo) sekune dzimwe nyika, uye kurwisa.
Nokuda kwechikonzero ichi vanhu vanopiwa immunosuppresive drugs zvinotevera stem cell transplant.
Asi zvirwere zvekudzivirira muviri zvinowedzerawo ngozi. Kupera kwemaitiro ekudzivirira zvirwere nekuda kwezvinodhaka izvi kunowedzera njodzi yehutachiona hwakakomba, uye kunowedzerawo mukana wekuwedzera dzimwe kenza.
Alternatives
Kupinda PBSCT inzira huru. Handizvo chete zvinotangira nechisimba zvikuru chemotherapy, asi zviratidzo zvekubatanidza zvinokonzerwa nechirwere, uye zvinetso zvemishonga inorwisa zvirwere zvinouita iyo nzira inowanzochengeterwa vaduku, uye inowanzo hutano hwakanaka, vanhu.
Imwe nzira inogona kuongororwa kune varwere vakwegura kana muhutano husinganzwisisiki isiri myeloablative stem cell transplant. Mune nzira iyi, pane kubvating (kunyanya kuparadza) marora emapfupa ane chikwata chakakura chemotherapy, chirwere chepasi chemhemotherapy chinoshandiswa. Chinhu chakavanzika pamusana pezvipembenene izvi zvinonyanya kurara mumhando yekubatanidza nekusangana nechirwere. Asi, panzvimbo pekubatanidzwa - iyo inoshandiswa shina masero - kurwisa "zvakanaka" masero mumutumbi unogamuchirwa, masero ekutengesa emasero anokonzera masero anouraya mumutumbi unogamuchirwa. Iyi miitiro inonzi "kubatanidza kubvisa tumarara."
Uyewo Anozivikanwa Se:
PBSCT, Peripheral Blood Stem Transplantation
Related Terms:
HSCT = hematopoietic stem cell transplantation
HCT = hematopoietic cell transplantation
SCT = stem cell transplant
G-CSF = Granulocyte-coloni inokurudzira chikonzero - kukura, chinhu chinowedzera kushandiswa kwemishonga, dzimwe nguva kunopiwa kuvabatsiri kuunganidza hematopoietic stem masero kubva mumasese emapfupa kusvika mune imwe ropa.
Sources:
National Cancer Institute. Cell Cell Stp Transplant. Kusunungurwa 04/19/15. http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant
Singh, V., Kumar, N., Kalsan, M., Saini, A., naR. Chandra. Mechanism of Induction: Inobatsira Pluripotent Stem Cells (iPSCs). Nhamba yeStem Cells . 2015. 10 (1): 43-62.
Wu, S., Zhang, C., Zhang, X., Xu, Y., uye T. Deng. Inopera ropa kana mapfupa emapfupa zviri nani kune mamwe masero emagetsi ekugadziriswa mumamiriro ezvinhu eHLA-akabatana nevatsigiri vasingabatanidzi? A meta-analysis. Mazano Anotsoropodza muOnology uye Hematology . 2015. 96 (1): 20-33.