Maitiro Ekuti May Statins Angakanganisa Sei Vanhu Vanorwara Kanonzi?
Statin Zvinodhaka uye Lung Cancer
Iwe ungangodaro wakanzwa kuti mishonga yemamashini inogona kuvandudza kuponeswa kwekenza yemapapu, kubatsira pamushonga, kana mukana wechidiki wemukenza wemapapu. Pakati pezvinhu zvose izvi, zvidzidzo zvinoratidzei? Vari kutaura pamusoro pekudzivirira chirwere chemapapu vasati vatanga, kana kurapa chirwere chemapapu mushure mokunge watovapo? Iro rudzi rwemapapu emapapu ane dambudziko uye runoita here kuti ndeapi mamwe marapirwo aunoshandisa?
Masayendisiti dzimwe nguva anoshamisika apo kurapwa kwechimwe chimiro kunoratidzika kubatsira pakusagadzikana. Statins zvinodhaka zvinogona kuva chimwe chezvirapa izvi. Iyi mishonga inoderedza cholesterol pakati pemamwe mabasa ndeimwe yemishonga inowanzozivikanwa pasi pose. Vatsvakurudzi vakatorazve kufarira madhiragi aya mumakore achangopfuura mushure mekuona kuwirirana pakati pekushandisa kwemishonga iyi uye kupona kwekenza.
Chii chinonzi Statins?
Statins inhengo yemishonga inonzi HMG-CoA reductase inhibitors. Kunyange zvazvo vanhu vakawanda vachiona mishonga iyi se "cholesterol inoderedza madhiragi" chinangwa chavo chikuru ndechokuderedza ngozi yekushaya mwoyo. Mukuwedzera pakuderedza cholesterol, mishonga iyi inogadzirisa zvirongwa mumaroto e coronary , kuderedza ukuru hwemavara mumaroto e coronary, uye kuderedza ropa rekuvhara ropa mumakoronary coronary. Sezvakadaro, mazita emitemo anogona kuderedza ngozi yemwoyo kunyange neyekuri cholesterol.
Kune rumwe rutivi rwema equation, kurapa yakakwirira yeholesterol maitiro chete - kunze kwekuti ichiita mutsauko mune hutano nekupona - haisi chinangwa chemurapa unonzi statin.
Zvingaita sei kuti Statins Ive Nayo Ngozi yeCcercer?
Zvidzidzo zvezvipfuwo uye zvidzidzo zvemasero (kutarisa kenza kemumera yakadyarwa mundiro) yakaratidza kuti mitemo ine anti anti cancer.
Inofungidzirwa kuti inogona kudzivirira tumarara sekukura, kupindira, uye kukwanisa kwekenza masero kupararira (metastasize.)
Maererano neboka rimwe revatsvakurudzi, mitemo inowedzera lipophilic (mafuta-ane rudo) yaizobudirira zvikuru. Mamwe lipophilic zvinyorwa zvinosanganisira Lipitor (atorvastatin), Zocor (simvastatin), uye Mevacor (lovastatin). Pasina lipophilic (yakawanda hydrophilic kana "mvura-inoda") mitemo inosanganisira Pravachol (pravastatin), Crestor (rosuvastatin), uye Lescol (fluvastatin).
Statins uye Kuparara Kwechirwere Chechirwere
Kuongororwa kwemazuva ano kunoratidza kuti vanhu vanotora mishonga yemagetsi kare kana mushure mekunge vaongororwa nekenza yemapapu vangave nekuwedzera kwehupenyu hwekugara.
Mune chidzidzo chevanhu vanosvika 14 000 vane kenza yemapapu muUk pakati pe1999 na2009, vanhu vakanga vashandisa statin zvinodhaka vasati vaongororwa vaive nehuwandu hwekuderedza 12 muzana muhutano hwemapfupa emapapu.
Kune avo vakashandisa chimiro chemishonga mushure mokunge vawana chirwere , uye vakararama kwemwedzi inenge mitanhatu, pakanga pasina kuwandisa kusina kuwandisa mumapapu emapapu emapfupa gumi nezana. Kune avo vakazadza zvinyorwa zvavo kanenge kaviri (dzinoshandiswa kwegore kana kupfuura,) pakanga paine kuderedza kuwandisa kwepabonde mumapapu emapapu ema19 %.
Ichi chidzidzo chaive nevanhu vane muto wemukati wemapapu musati uri muduku uye mukenza mutsva wemapapu emapapu uye unoshandura kusvika ku3 638 varwere vemapapu emapapu avo vakave nekuderedza kuve nehutano hwemapapu emapapu. Kudai nhamba idzi dzaizoshanda kune vanhu vakawanda vane chirwere chemapapu, izvi hazvizove nhamba duku, sezvo zvinotarisirwa kuti vanhu 158.040 vachafa nemukenza wemapapu muna 2015 muUnited States chete. Sekuenzanisa nokukurumidza, vanenge 3 000 vanhu vanofa mumoto unofanirwa kumusha muUnited States gore negore.
Zvakakosha kucherechedza kuti kutsvakurudza uku kwakatanga , uye hatigoni kuva nechokwadi kuti iri mishonga yemademoni pachayo inokonzera kuderedzwa kwevakafa .
Semuenzaniso, panogona kunge kune chimwe chinhu (chimwe chinowanikwa) kuvanhu vanoshandisa zvinodhaka zvinoshandiswa asi zvinosanganiswa nekuvandudza kupona.
Statins uye Chirwere Chechirwere Chekufa
Kuongorora kwezvidzidzo zvakabudiswa munaApril 2015 (zvidzidzo makumi maviri nemashanu) zvichicherechedza kuitika kwemasimoni pamusoro pehutano hwehutano hwekenza, zvinoita sekutsigira pfungwa yokuti mitemo inogona kukanganisa kurarama kwekenza. Izvi zvidzidzo, zvinosanganisira vanhu vanosvika mamiriyoni evanhu zvachose, zvinoratidza kuti kushandiswa kwemasimoni mushure mekuongororwa kwekenza kunobatanidzwa ne 19% kuderedzwa kwezvose-zvinokonzera kufa uye 23 muzana kuderedzwa kwevanhu vanofa nekenza. Mhedziso yevanotsvakurudza kutarisa idzi zvidzidzo ndeyekuti "kushandiswa kwemashini mushure mokunge uye mushure mekuongororwa kunobatsira mukurarama zvachose nekurarama-kukanganisa-zvakananga kupona." Zvakakosha kuziva, zvisinei, kuti kenza yemapapu chete inopera shure mune dzimwe dzedzidzo idzi, uye nedzidzo dzakawanda dzakatarisa kenza yemazamu, kenza yemaronda, uye kenza yeprotate.
Migumisiro yeStatines pamusoro peChirungu cheKenza Cancer
Hazvisi zvakawanda zvinozivikanwa pamusoro pekuti mitemo inobata sei kurapwa kwemunhu kune kenza, asi kumwe kuongorora kwechidiki kwakawana kuti kuwedzerwa mutemo kumishonga yakafanana neTarceva kwakaguma nokuwedzera kunokosha mukupfuura-kusina kusununguka kune vanhu vane kamudiki kadiki kenza yemapapu kweKRAS mutation. Nyaya ino inokurukura kuongororwa kwemashanduko emagetsi muvanhu vane mutsa wemapapu .
Nenzira, vanhu vanoedza kuti vawane mutsauko weKRAS havapinduriwo nemishonga inonzi epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR-TKIs ). Mishonga munharaunda iyi (yakarongwa nemishonga) inoshandiswa mumukenza wemapapu inosanganisira Tarceva (erlotinib) uye Iressa (gefitinib). Mune vanhu vane chirongwa chechitatu 3B uye nhanho 4 isina kechidiki chekenza yemapapu yemapapu inobatsira pakuchinja mutauro weKRAS, kuwedzerwa kwechimiro kwakapetwa kaviri urefu hwekupona kusina-kusununguka.
Pakutanga zvidzidzo pamasero emukenza wemapapu evanhu zvakawanawo kuti kuwedzera maitiro emagetsi emukenza asina kukodzera. Zviri nyore, zvinofungidzirwa kuti iyo statin inoguma nekuderera kwe isoprenoids iyo inobatsira paRAS - saka zvinoita pachena pamasero emapapu emapapu ane mutsauko weKRAS.
Statins uye Muchengetedzo WeKenza Kudzivirira
Kunyange zvazvo zvidzidzo zviduku zvakakura zvisina kuwana hukama pakati pekudzivirirwa kwekenza nemapapu, kuongorora kwechangobva kuitika kuTaiwan kwakaratidza kuti zvinogona kuitwa, kunyanya kuvakadzi, kunyanya avo vane dzimwe mamiriro ekufema zvakadai seCOPD uye mapirmaria tuberculosis . Vatsvakurudzi vakaenzanisa vakadzi vanopfuura 17 000 vasina kenza yemapapu nevakadzi vanopfuura 17 000 avo vakaonekwa kuti vane kenza yemapapu pakati pe2005 na2010. Kushandiswa kwenguva refu kweZocor (simvastatin) kwakabatana ne 20% mucheche wepamusoro wekenza yemapapu zvichienzaniswa nevakadzi vasina kushandisa mishonga. Kushandiswa kwenguva refu kweMevacor (lovastatin) kwakanga kusina, asi, kunobatanidza nehuwandu hwehutachiona hwechirwere.
Dzidza nezvekukakavara kwechangobva kuitika pamusoro pekushandiswa kwemasimoni kuvakadzi .
Chii Chaunofanira Kuita Nemashoko Aya?
Sezvakataurwa pamusoro apa, kutsvakurudza uku kuchiri muhucheche, uye mazano pamusoro pemutemo anoshandiswa zvakananga kune kenza haina kuitwa. Kune avo vave vachishandisa mishonga yemasitini yekolestori yakakwirira munguva yekurapa kwekenza yemapapu, zvidzidzo izvi zvinogona kuva zvinyaradzo. Unogonawo kufarira kukurukura mamiriro ako chaiwo kusanganisira iwe unhu hwepachivi uye wako oncologist uye kumubvunza kuti chii chaanofunga nezvemashoko aya.
Iyi ruzivo inouyawo nenguva iyo mazano ekare pamusoro pekushaira kwekutsvaira yakagadziriswa. Muna December wegore ra2014, gwaro rakanyorwa reDetary Guidelines Advisory Committee rakataura kuti cholesterol yezvokudya haisati yaonekwa sechinhu chinokonzera kukanganisa. Izvi zvakajeka hurukuro inoda kuzokurukurwa uye iwe pachako pakati pako newe oncologist yako.
Zvitsva Zvitsva
Kune zvimwe zvinhu zvakajeka vanhu vanogona kuzviita ivo pachavo nekuvandudza kupona nemukenza wemapapu. Tarisa zvinhu izvi gumi zvinogona kuvandudza kupona kwako kubva mumukenza wemapapu .
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