Emerging Treatment Shows Promise
Overview
Naltrexone imishonga iyo, pamutengo unowanikwa we 50 kusvika ku100 mg, inodzivisa migumisiro yeopioid. Panyaya yakaderera zvikuru, zvisinei, vamwe vatsvakurudzi vanodavira kuti mishonga inogona kubatsira kune vanhu vane fibromyalgia uye vasina kukanganisa zvirwere ; zvirwere zvekudzivirira / zvirwere zvinoputika zvinosanganisira multiple sclerosis , yakaoma nzvimbo yekurwadziwa chirwere, uye Crohn's disease; uye dzimwe zvirwere zvine utachiona, zvakadai seHIV / AIDS .
Low-dose naltrexone (LDN) mishonga isingadhuri yakatova pamusika, iyo yakaita kuti kufara pamusoro pekushandisa kwayo kunogona kushandiswa. Kutsvakurudza kuri kufamba zvishoma nezvishoma, zvisinei, zvichida nokuti hapana mari yakawanda inokurudzira.
DDN inoshanda sei?
Vatsvakurudzi havasati vanyatsonzwisisa mishonga yacho chaiyo yekuita. Vamwe vatsvakurudzi vanotaura kuti LDN inodzivirira mamwe mapepa mumutambo wenheyo unokonzera zviratidzo zve fibromyalgia uye isingagumi kuneta.
Humwe humwe humwe hunoratidza kuti LDN inoshanda se-anti-inflammatory mukati nepakati pese nheyo dzenharo, zvichida nekudzivirira basa remasero anonzi microglia.
Kutsvakurudza kunoratidzawo kuti LDN inogona kubatsira kusimbisa maitiro ezvirwere zvezvirwere zvezvirwere, izvo zvinogona kunge zvichiita kuti zvionekwe kubatsira vanhu vane hutachiona uye mamwe zvirwere zvezvirwere zvezvirwere.
Dzidza zvakawanda pamusoro pekuputika uye autoimmunity mu fibromyalgia uye kusingaperi kuneta kwechirwere:
For Fibromyalgia
Chikwata cheStanford zvidzidzo zvakaratidza migumisiro yakanaka-yakawanda se 30% inoderera muzviratidzo zvichienzaniswa ne placebo. Vanotsvakurudza vanoti migumisiro yakanakisisa kune vanhu vane zvakanyanya sedimentation rates, iyo inoratidza kupikisa kwemuviri mumuviri.
(A high sed rate inogona kuratidza mamiriro ekuputika sezvo isingawanzosimudzirwa mu fibromyalgia.)
Migumisiro inoratidza zvakare kuti mushonga wacho unobvumirwa zvakanaka.
Kunyange zvakadaro, zvidzidzo izvi zvose zvave zviduku uye basa rinoda kuitwa musati taziva kuti DD yakachengeteka uye inobudirira ndeyeiyo mamiriro ezvinhu.
LDN haisi FDA inogamuchirwa zve fibromyalgia asi dzimwe nguva inorayirwa kure-label.
For Chronic Fatigue Syndrome
Kusvika ikozvino, LDN haina kuongororwa pamusoro pekusingaperi kuneta kwechirwere. Zvisinei, vamwe vanachiremba nevarwere vanoti vanoti vakashandisa zvakanaka.
Nehuchapupu huchangobva kuitika hunoratidza kuti mukana wekuti chirwere chisingaperi chine utachiona uye chirwere cheLDN chinokonzerwa nekuputika mumamiriro emagetsi, tingave tichiona kuti nei ichi chiri kurapa kune vamwe.
Sezvo ne fibromyalgia, LDN dzimwe nguva inorayirwa kure-label kune chisingagumi kuneta.
Dosage
Kuti ishandiswe mukurapa fibromyalgia kana kusagadzikana kunetseka, chirtrexone inowanzopiwa mumitambo ye 4.5 mg kana pasi. Kazhinji, iwe unotanga pa 1.5 mg, unoshanda kusvika 3 mg, uye uwedzere kusvika ku4,5.
Migumisiro inobatanidzwa pamutsetse uyu wakaderera haisi kuonekwa pamadhora akawanda.
Migumisiro Yechiri
Kunyange zvazvo LDN ichiita seyakabvumirwa zvakanaka, zvinokonzerwa nemigumisiro ye naltrexone inosanganisira:
- chizoro & syncope (kuneta)
- headache
- kusuruvara
- kushushikana nekutya
- kurara uye kuneta
- kushungurudza, kurutsira, chirwere, marwadzo emimba / kuponda, kuderedza chido
- injection site site pain & gleaning
- joint pain
- kunyanyisa musimba kuputika
- kumusoro kupumhidza marwadzo
- huro inorwadza
Muchidzidzo cheStanford, migumisiro yakasvibiswa yakasarudzwa sevasingawanzi, zvinyoro, uye zvishoma.
Vanhu vane kidyo kana chirwere chechiropa vangada zvirongwa zvakananga kana madhaseti kuti vakwanise kutora LDN. Izvi zvinogona kuve zvinokuvadza kumwana asati aberekwa. Hatisati taziva kana inopinda mumukaka wemukaka.
LDN uye Opioid Painkillers
Mune mazamu makuru, naltrexone inoshandiswa kune vese vanobva kune opiate (narcotic) painkillers dzakadai saVicodin (hydrocodone acetaminophen) uye OxyContin (oxycodone) nokuti inodzivisa kushanda kwavo muuropi.
Izvozvo zvinoshandiswa pakushandiswa kweipiate pakaderera maitiro zvisingazivikanwi zvakadaro, asi zvinoonekwa sechinhu chakaipa chokubatanidza mishonga iyi. Iva nechokwadi chekutaura nachiremba wako nezvekureba kwei iwe unofanira kunge uine opioid usati watanga LDN.
Zvakakunakira Here?
Kana iwe uchifarira kuedza LDN, taura nachiremba wako pamusoro pezvinogona kuitwa uye zvakashata. Nepo vamwe vanachiremba vanopa LDN kune vanhu vane zvirwere izvi uye nevamwe vakawanda, zvichiri kuonekwa sechirwere chinotanga kubuda, saka chiremba wako angave asingadi kuzvifungisisa.
Sources:
Ablin JN, Buskila D. Maonero emudzidzisi pamusoro pemishonga inotanga kubuda. 2010 Sep; 15 (3): 521-33. Emerging therapies for fibromyalgia: an update.
Plesner KB, Vaegter HB, Handberg G. Ugeskrift ye laeger. 2015 Nhasi 9, 177 (43): V03150248. Low dose naltrexone yekurapa marwadzo. [Abstract referenced. Chirevo muDanish.]
Muduku J, Mackey S. Pain mishonga. 2009 May-Jun; 10 (4): 663-72. "Fibromyalgia Dhiyabhorosi Inoderedzwa neA-Low Dose Naltrexone: A Pilot Study."
Muduku J, et al. Arthritis uye rheumatism. 2013 Feb; 65 (2): 529-38. Iko-dose nealterxone yekurapa kwefromromyalgia: kuwanikwa kwediki, randomized, double-blind, testboo-controlled, counterbalanced, test-crossover kuongorora maitiro emarwadzo ezuva nezuva.
Muduku J, Parkitny L, McLain D. Clinical rheumatology. 2014 Apr; 33 (4): 451-9. Kushandiswa kwepasi-dose naltrexone (LDN) senhoroondo inozvidzivirira-kupisa simba yekutambudzika kusingaperi.