Kutsvakurudza Kunotsanangura Zviratidzo
Tsvakurudzo mune zvisiri-celiac gluten senitivity - inozivikanwawo sekusagadzikana kwe gluten - kuwedzera kuri kuratidza kuti iwe unogona kuwana zviratidzo zvakakomba kubva kune gluten kudya kunze kwekushaya chirwere ichi .
Mukutsvakurudza kwakajeka pamusoro pekunzwisisa kwe gluten kwakabudiswa kutanga kwegore ra 2011, mutsvakurudzi akakurumbira wemudzimai weCleacac Dr. Alessio Fasano akagumisa kuti "senzwi" gluten inomiririra mamiriro akasiyana zvachose kubva kune chirwere ichi, uye vazhinji vevanhu vanotambura nekunzwisisa kweGluten havazombogadziri chinhu ichi.
Kunyange zvazvo tsvakurudzo yake iine chido kune vezvechipatara, zvakakosha kuziva kuti kutsvakurudza kwake kusati kwave kudzokororwa saka saka vezvechiremba vakawanda vari kufunga kuti iyi inyanzvi mukugadzirwa.
Dr Fasano uye boka rinoumbwa nevatsvakurudzi vezvechireyi vakakurumbira, kusanganisira Drs. Peter Green (mukuru weColumbia University Celiac Disease Center) naDr. Marios Hadjivassiliou (nyanzvi yezvechiremba uye nyanzvi mune gluten ataxia ), vakatevera chidzidzo chekutanga nekubvumirana kwakabudiswa munaFebruary 2012 vachiratidza nzira dzekusiyanisa pakati pezvirwere zvechiliac, gluten kunzwisisika, uye gluten ataxia.
Zvimwe vatsvakurudzi zvakare vane chimed mune nekuwana. Zvimwe zvidzidzo zvinoratidza kuti vamwe vanhu vane guten vane maitiro akafanana emagetsi ekuzivikanwa kuti celiacs, zvichiratidza kuti panogona kuva nemamiriro ekutanga asati asvika. Zvimwe zvidzidzo zvakare kuna Dr. Fasano zvakawanikwa kuti gluten inogona kuita zviratidzo kune vanhu vasina chirwere chechiiac classic.
Kutsvakurudza muhutu hwemagetsi kunowedzera nokukurumidza. Mukuwedzera, kakawanda, kakawanda, vanhu vane chirwere chekushaya ropa chechiliac asi chirwere chisina kunaka chiri kupiwa kuongororwa kwehutano hwehutu.
Mune zvimwe zviitiko, chiremba wavo anoti vanogona kudya gluten mukuenzanisa, kana kuti vanoudzwa kuti vatevere kudya kwema gluten asi kuti havadi kuti vave vakangwarira sevashandi veeceliac.
Vamwe vanoudzwa kuti "vanogona" chirwere chechiliac varwere, uye kutarisa zvakare mugore rimwe chete kana zvakadaro kuti vawedzere kuongororwa kuona kana vakagadzira chirwere chacho.
Kutsvakurudza kwakawanda kuchadiwa kuti uone kana vanhu vane gluten senzwive zvechokwadi vanogona kunwisa zvishoma zvishoma gluten pasina kukuvadza, kana kana rimwe boka reboka re-gluten-senzwi richapedzisira richienda kukura chirwere ichi.
Verenga zvakawanda pamusoro pengozi dzehutano hwehutano muhutano hwehutano: Gluten Sensitivity Health Risks
U. weMadgan Pegs 'Gluten Sensitivity' seChiratidzo Chaicho
Muna Dr. Fasano's initial gluten senitivity tsvakurudzo, yakabudiswa paIndaneti muna March 2011 muna BMC Medicine , vatsvakurudzi vakawana kusiyana kwakasiyana pakati pezvirwere zvechiliac uye senzwi re gluten pamaseroti, kunyange zviratidzo zvemamiriro maviri aya zvakanyanyisa.
Dr. Fasano uye imwe yunivhesiti yeMadganic vatsvakurudzi vakafananidza 42 vakawana ma-celiacs avo vaiva Marsh 3 kana Marsh 4 mumatambudziko ekuvhiringidza nevarume 26 vane mazamu avo vakaratidza zvishoma kana kusakanganiswa, asi avo vachiri pachena zvakajeka kune gluten.
Pamusangano mumwe nomumwe, vatsvakurudzi vakagadzirisa hutachiona hwepachivi (muchirwere chechiliac, matumbo ako anowedzera kubvumira, izvo zvinogona kubvumira mapuroteni kutiza muropa).
Vakatarisawo mazamu, pamwe nekutaura kwemajeni mumatumbo maduku.
Chidzidzo chacho chakawana kusiyana kwepachiviri chekudzivirira pakati pemapoka evanhu, pamwe nekusiyana kwekutaura kwemajeni anogadzirisa zvirwere zvemuviri. Izvozvo zvinoratidza kugunun'una kwejuten yakasiyana nedambudziko remhepo iyi , maererano naDkt Fasano.
Kusiyanisa muCeliac, Gluten Sensitivity Stem Kubva kuImine System System Mhinduro
Kusiyana pakati pemamiriro maviri aya kunobva kune kusiyana kwezvirwere zvemuviri, Dr. Fasano anoti.
Mune hutachiona hwe gluten, iyo innate immune system - imwe yekare yezvirwere zvemuviri nemuviri wekutanga wezvidziviriro kune vanoparadza - inopindura gluten ingestion nekurwisa gluten zvakananga.
Izvo zvinokonzera kutuka mukati uye kunze kwegadziriro yekudya, maererano naDkt Fasano.
Munguva iyi, chirwere chechiliac chinosanganisira zvose zvirwere zvemuviri zvisinganzwisisiki uye iyo inogadzirisa immune system, anodaro. I-adaptive immune system ndiyo yakanyanyisa, yakanyatsogadzirisa chikamu chemuviri wechirwere chemuviri, uye kushamwaridzana pakati pemagadzirirwo emagadzirirwo emagetsi emasero anotungamirira masero aya kurwisa muviri wako maviri, zvichiita kuti mweya unotyisa uonekwe muchirwere ichi.
Vanhu vane kugunun'una kwe gluten havakwanisi kuora mwoyo, kunyange vachikwanisa kuwana zviratidzo zvinenge zvakafanana kune celiac, kusanganisira kubuda , kuputika, kurwadziwa mumimba, kurwadziwa pamwe chete , kuora mwoyo , uturu hwehupombwe uye migraines, maererano naDkt Fasano. (Verenga zvakawanda pamusoro pezviratidzo zviri pano: Gluten Sensitivity Symptoms .)
Zvisinei, vanhu ivavo chete vane mafungiro emagadzirirwo emagadzirirwo emagetsi echinokonzerwa nehosha yeecliac vari pangozi yekudzika mumatumbo lymphoma nemamwe mamiriro ezvinhu anosangana neecliac, zvakadai seansteoporosis , Dr. Fasano anoti.
Vamwe vevanhu vane guten vakabatanidzwa muDkt. Fasano yekudzidza vakanga vane hutano hwemucheche hutachiona (hwakarongerwa se Marsh 1 kana 2 ), asi kukuvadza ikoko kwaiva nemhando dzakasiyana-siyana kune iyo inowanikwa mune chirwere chechiliac.
'Zvingaita' Varwere Vechidiki Vanoparadzanisa Zvimwe Zvinyorwa Zvinyorwa Zvinyorwa NeCeliacs
Pane humwe tsvakurudzo inoratidza kuti vamwe vanhu vanonzi "gluten-sensitive" inogona, muzviri, kuva nekutanga kwepachirwere ichi.
Chimwe chidzidzo chakabudiswa munaDecember 2010 Journal of Proteome Research inowana kuti "vanokwanisa" varwere vecliac vane zviratidzo zvakanaka zvekutsvaga asi zvirwere zvisingaiti chaizvoizvo zvine zvimwe zvakafanana zvinyorwa zvemagetsi sezvinoonekwa kuti celiacs. Izvo "vanhu vane" gluten "vanogona kungomiririra danga rekare remamiriro acho ezvinhu zvisati zvakonzera kukanganisa kukuru kumatumbo, vatsvakurudzi vakati.
Chidzidzo chacho chakashandisa magnetic resonance magadzirirwo emagetsi ekuongorora mararamiro emakemikari mumuguta uye neropa revarwere 141: 61 vane chirwere chechiliac chakaongororwa, 29 vane maitiro akanaka ekutsvaga ropa asi akaipa biopsies, uye 51 utano hwakanaka.
Vakaona kuti avo vane zvinonzi "vanogona" chirwere chechiliac vakagovana maitiro ezvinyorwa zvehupenyu sezvakaonekwa kuti izvi zvakanyatsozivikanwa, asi nhoroondo dzehupenyu hwehutano hwakasiyana dzakasiyana.
"Zvigumisiro zvedu zvinoratidza kuti kushandiswa kwemagetsi kunogona kutangira kukura kwechidiki chepachivi chinokanganisa uye kuchipa chimwe chikonzero chekutanga kwechirongwa cheGFD [kudya zvisina kudya] mune varwere vane koneti ye [cecaac disease]," yakagumisa kudaro.
Gluten Sensitivity Inogona Kuitika Muvarwere NeBorderline Biopsies
Chimwe chidzidzo chakatarisa varwere vane zviratidzo zvehutachiona zvechiliac uyo mazamu emakumbo akaratidzwa zvisiri izvo zvishoma, zvakadai seMarsha I kana II mazonda .
Vanachiremba vazhinji havazogoni kuziva chirwere chechiliac kunze kwekunge muviri wekurwadza uchisvika Marsh III kana Marsh IV mazinga.
Muchidzidzo ichi, varwere 35 vaiva nehuwandu hwekukuvara uye vakaudzwa kuti vatevere kudya kusina guten chero zvakadaro. Vashandi 23 chete vanoteererwa kudya uye vatsvakurudzi vakatora maitiro ekutevera kubva kune wese munhu ari kutevera kudya shure kwemwedzi misere kusvika kune gumi nembiri.
Vose 23 varwere vaitevera kudya kwaiva ne "kunakidza kwekurapa kwezviratidzo," uye vazhinji vakaona kupora kwakakwana kana kusarura kwemukati mavo villi.
Vane vanomwe nevarwere 11 vakaramba kutevera kudya kweguten vakaongororwa mwedzi misere kusvika 12, zvakare. Pakati idzi, zvitanhatu zvakanga zvisingashanduki zviratidzo uye muviri wekukuvara uye zvakare vakaramba kutanga chironga chisina-gluten. Mumwe akaona kuwedzera kukuvadzwa mumukati wake villi (kubva Marsh I kusvika Marsh IIIa) uye akasarudza kutanga kudya.
Vanyori vekudzidza vakagumisa kuti varwere vasina kukwanisa kugadzirisa zvirwere zvechiliac zvakadaro zvakadaro zvakajeka kuti gluten yakagadzikana uye yakabatsirwa nechirwere chisina-gluten.
"Kunyange zvazvo Marsh I-II zvipembenene hazvikwanisi kuiswa sezvilonda zveecliac, zviratidzo zvevarwere pahurukuro uye kujekesa kwakanaka kwezviratidzo apo paGFD [kudya-gluten-isina kudya], kana pasina kana kugadziridzwa kwezvipembenene zve histologic, zvinotsigira pfungwa yokuti varwere ava vanonzwisisa gluten uye vanogona kururamisa kurapwa neGFD, "vakatsvakurudza vakapedzisa.
Gluten Sensitivity May Inogona Kuita Munhu Muvanhu 14
Gluten senitivity (kana kusawirirana) kunogona kukanganisa 6 kusvika ku7% yevanhu, maererano naDkt Fasano. Vamwe vari munharaunda yezvokurapa vakaisa huwandu hwevamwe vanhu vane hutano-husingawirirani-ndakaona kuongororwa kubva kubva pa10% kusvika kune mammoth 50% evanhu.
Verenga zvakawanda pamusoro pezviwero izvi: Vanhu Vangani Vane Gluten Sensitivity?
Hazvibviri kutaurira kuti vanhu vangani vechokwadi vane gluten senitivity pasina tsvakurudzo uye vakagamuchira gluten senitivity test . Asi zvakajeka, kunyange kana nhamba dziri kurutivi rwepasi, dzichawedzera nhamba yeeceliacs, inoumba inenge 1% yevanhu.
Vakawanda vari munharaunda yeeceliac / gluten vanofunga kuti zvirwere zvinokonzerwa ne gluten vanozvienzanisa pachavo "nezvimwe" zvinokonzerwa ne-gluten, nechirwere cheecyac, gluten ataxia (kukuvara kwehutano kubva kune gluten) uye kugunun'una kweGututen yose inowira pane imwe nzvimbo pachiitiko ichocho.
Dr Fasano anoti danho rinotevera nderokuzivikanwa kwechirwere chezvinyorwa, kana "biomarker," nokuda kwekunzwa kwehutano. Chirwere chemakiriniki kuita izvozvi zviri kuitika iye zvino, uye Dr. Fasano anoti "ane chivimbo" vatsvakurudzi vacharatidza kuti biomarker. Kubva ipapo, vatsvakurudzi vanogona kukura muedzo kuti vaone kutaridzika kwe-gluten - iyo inogona kuwanikwa mune zvekutengeswa mukati memakore akawanda akatevera.
> Sources:
> Bernini P. et al. Vaya Varwere Vane Zvimwe Zvirwere zveCeliac Zvechokwadi Zvinogona Here? Mhinduro yeMetabonomics. Zvinyorwa zveProteome Research. Yakabudiswa paIndaneti Nov. 19, 2010. DOI: 10.1021 / pr100896s.
> J. Biesiekierski et al. Gluten Inokonzera Maviri Ezviratidzo Muzvidzidzo Pasina Celiac Disease: A Double-Blind Randomized Placebo-Controled Trial. American Journal yeGastroenterology inotanga kubudiswa muIndaneti, Jan. 11, 2011; doi: 10.1038 / ajg.2010.487.
> A. Fasano et al. Kutengesa kweGuin Permeability uye Mucosal Gene Immune Zviratidzo muZviri Mamiriro Akabatanidzwa neClubuten: Celiac Disease uye Gluten Sensitivity. BMC Medicine 2011, 9:23. doi: 10.1186 / 1741-7015-9-23.
> Fasano A. et. al. Spectrum yematambudziko anokonzerwa neG Gluten: Consensus pamusoro peNew Nomenclature nekutsvaga. BMC Medicine. BMC Medicine 2012, 10:13 ini: 10.1186 / 1741-7015-10-13. Yakabudiswa: 7 February 2012
> Tursi A. et al. Mhinduro yeAchimptomatic and Histologic kune kudya kweGluten-Pasina zvirwere neBorderline Inopathy. Zvinyorwa zveKliniki Gastroenterology. 2003 Jan; 36 (1): 6-7.