Kuyera Uhupupu Mukutsigira Iropiyo
Intravenous immunoglobulin (IVIG) inorudzi rwechirwere umo musanganiswa wezvirwere (immunoglobulins) inorohwa muine mutezo nechinangwa chekuvandudza muviri wemunhu. Zvirwere zvirwere zvinodzivirira mapuroteni anobudiswa nemuviri mukupindura chirwere.
IVIG inofungidzirwa kuti inoshanda mune zvirwere zvehutano kuburikidza nekukurudzira dzimwe nhengo dzomuviri wechirwere chekuzvidzivirira uye kudzivisa vamwe.
Hapana anoziva kwazvo kuti inoshanda sei, uye, saizvozvowo, IVIG inorayirwa kure-label (pasina ruzivo rwakananga rweDAA) kune zvirwere izvo zvirwere zvemuviri zvemunhu zvakanyanyiswa.
Izvi zvinogona kusanganisira neonatal sepsis, HIV yevana, uye zvimwe zviitiko zvehutachiwana hweHIV . Inoshandiswawo sechipiri-linerapi kurapa kurapwa mukudzokazve -remitting multiple sclerosis (RRMS) .
Zvishandiso zveVIG mu Multiple Sclerosis
IVIG inoshandiswa mune multiple multiple sclerosis (MS) kuenderera mberi kunonoka kwechirwere uye kugadzirisa kuremara kunokonzerwa nechirwere chacho. Nepo pasina chibvumirano chakajeka chekuti kana IVIG yakakosha zvakadini, yakaratidza chivimbiso kune dzimwe nzvimbo dzakasiyana-siyana:
- Kuchengetedza MS kudzoka zvakare mumubereki wekupedzisira
- Kurapa vanhu vakakundikana mushonga wekutanga weRRMS uye havagone kuregerera mishonga yemagariro -inogadzirisa zvirwere
- Kurapa MS yechipiri yekufambira mberi (kunyange zvakadaro pane nharo hurukuro pamusoro pekushanda kwayo)
Zvimwe zvidzidzo zvakare zvakaratidza kuti IVIG inopiwa panguva yekutanga maitiro emagetsi eWS (anonzi chirwere chekliniki chega, kana CIS ) inogona kuderedza mukana wemunhu wekushandura kugadziriswa kweSMS. Zvakawanda zvekutsvakurudza zvakare zvakasangana nekusava nechokwadi kana kusava nechokwadi.
Kubudirira kweVIVI
Panguva ino, hapana anoziva kunyatsobudirira kweVIG mune mukurapa kana kuderedza kufambira mberi kweSMS.
Zvizhinji zvehuchapupu hwave hwakavakirwa pamigumisiro yadzo pane dzimwe zvirwere zvehupombwe , zvakadai saGuillain-Barré syndrome uye myasthenia gravi s. Zvidzidzo zvakarongedza zvakananga kuVIV uye MS zvakave zvakakanganiswa pane zvakanakisisa.
Imwe yedzidzo yeAustralia yakaratidza huwandu huri nani asi hunoti hunoita huri nani mukuremara sezvakaenzana nehuwandu hwechiremera chekuremara (EDSS) . Vamwe vakaratidza kuwedzera zvishoma muhukuru kana nhamba yezvipembenene zveuropi paMRI.
Vamwe, panguva iyo, havana kuratidza kusiyana kwehutano hweHIVI kuenzaniswa ne-placeboes mukurapa RRMS.
Zvichida imwe nzvimbo yechipikirwa ndiyo kushandiswa kweVIG mushure mekuberekwa, chiito chakaratidza kuti chinonyanya kuderedza kuwanda kwekudzokazve mumadzimai matsva.
Dosage uye Administration
Kunyange zvazvo kuwedzerwa uye kuwedzerwa kwemasero kusati kwave kwakagadzirirwa RRMS, vazhinji vanonyora vanorayira kuyerwa kwegamu imwe kirogiramu yehutatu hwehupi inopiwa mwedzi mumwe nomumwe. Vamwe vanozopa maitiro 400 mg / kg pazuva pazuva remazuva mashanu.
Migumisiro Yechiri
Nzira yakanyanya kufanana nayo yeVIG ndeyomusoro (iyo inowanzobatwa neye-over-the-counter painkiller seTylenol). Mimwe migumisiro yemigumisiro inosvibisa inosanganisira fivha, kurwadziwa pamwe chete, kurwadziwa kwepfupa, uye kushambidzika. Pashoma pfupi, kuputika kwechirwere chinogona kuitika.
Zvimwe zvakakomba asi zvisingabatsiri zvinokonzerwa zvakare zvakasanganiswa, kusanganisira aseptic meningitis , kurwisa kwemwoyo, kushungurudzika, zvakadzika mutsara, kushaya mafungiro, uye kushaya kwepvo.
Kuwirirana nekupindirana
IVIG haifaniri kushandiswa kune vanhu vane zvinetso zvepvo kana kushaya IgA (a genetic disorder inoratidzirwa nekushaikwa kwechirwere ichi chinodzivirira zvirwere mumuromo, mumhepo, uye munzira yekudya). A
Panguva iyi, IVIG inofanira kushandiswa nekuchenjerera kune vanhu vane:
- Zvinetso zvemwoyo
- Chirwere cheshuga
- Kutsigira ku immunoglobulins
- Kutsigira kune maltose kana sucrose (zvinoshandiswa zvinoshandiswa mune mamwe maitiro eVIG)
Iyo chete inotsanangurwa zvakajeka neVIV inosanganisira zvirwere zvehupenyu. Immunoglobulins inogona kupa chirwere chisingabatsiri uye chisingabatsiri chero chekudzivirira iyo mushonga unogona kuwana.
Mari yekurapa
IVIG yave inodhura zvikuru painofungidzirwa $ 100 per gramu. Kune munhu anorema makirogiramu makumi mana (70 kilograms), iyo inorayirwa miroji yemwedzi inoguma inodhura inodhura madhora 7,000 pamusana pekugadziriswa, kwete kusanganisira nzvimbo yekuchengetedza uye yekurapa mari.
Mamwe makambani einishuwarenzi anogona kuvhara mari yacho, asi kazhinji inonetsa kukurudzira kurapwa uye kazhinji inoda nzira yekukumbira kuti uwane kugamuchirwa. Kana yakagamuchirwa, inshuwaridho inobhadhara mari inogona kuva yakakwirira chaizvo. Zvisinei, vamwe vashandi veVIV vanopa zvirongwa zvekubatsira varwere (PAPs ) kuti vasiye kana kuvhara zvachose mari yekurapa.
Shoko Rinobva
Kana iVIV inokurudzirwa, iwe unogona kuzvidzivirira iwe pachako kuti uwane chibvumirano kubva kune inshuwarisi yako. Nezvo izvo zvataurwa, zvakakosha kunzwisisa zvinobatsira uye zvisingakwanisi kurapwa-zvakanyanya izvo zvitsvakurudzo zvinotitaurira uye hazvitiudze.
Kana iwe usina kunyatsojeka pamusoro peizvi, usazeza kutsvaka maonero echipiri kubva kune unyanzvi anoziva.
> Sources:
> Bayry, J .; Hartung, H ;; uye Kaveri, S. "IVIg yekudzokazve-kurega multiple sclerosis: zvipikirwa uye kusava nechokwadi." Trends Pharm Sci. 2015; 36 (7): 419-421.
> Gilardin, L .; Bayry, R ;; uye Kaveri, S. "Intravenous immunoglobulin semakiriniki emune-modulating therapy." CMAJ. 2015; 187 (4): 257-264.