Iko huchapupu huripo hunotsigira kushandiswa kwayo here?
Zvinokwanisika here kuti chirwere chinoshandiswa kuporesa opioid nekudhakwa kunwa doro kunogona kuvandudza hupenyu uye maonero evanhu vanogara ne multiple sclerosis (MS) ?
Imwe tsvakurudzo inoratidza kuti inogona. Kunyange zvazvo isingabvumirwi kushandiswa kwakadaro, chirwere chakanyanya naltrexone (LDN) chiri kuramba chichiendeswa kune-label kuti inobata kuneta kweMM-yakashata , chiratidzo chinowanzoonekwa uye chinowanzoodzadza chirwere chacho.
Kutenderwa Kushandiswa kweNaltrexone
Naltrexone yakagamuchirwa neU.S. Food and Drug Administration muna 1984 kuitira kurapwa kweapioid muropa uye muna 1994 kubata doro kushandisa dambudziko (AUD). Pakuzadzwa kwakakwana (50 kusvika 100 milligram pazuva), naltrexone inodzivirira maitiro eopioid uye inoita kuti munhu ashuke kunwa.
Mumakondomu maviri aya, naltrexone yakaratidzwa kuti inopa zvishoma kuti zvive nemigumisiro yakaipa mukuporesa kuwedzera asi inogona kubatsira kana inoshandiswa sechikamu chegadziriro yakarongeka, yakarongedzwa zvakananga.
Kubva-Kutora Kushandisa Naltrexone
Panguva iyo naltrexone yakatanga kukurudzirwa, vatsvakurudzi ve Penn Penn College College yeMishonga vakatanga kudzidza kushandiswa kwayo pakuchengetedza zvinetso zvekudzivirira muviri (uko maitiro ezvirwere zvekuzvidzivirira masimba anokanganisa masero emutumbi).
Multiple sclerosis inotendwa nevakawanda kuti inokonzerwa nemhinduro yekuzvimirira uye yaiva pakati pevadzidzi vepakutanga kutsvaga. Zvakawanikwa nevatsvakurudzi ndezvokuti kuderedza zvakanyanya kudhakwa kwechirwere kwakasimbisa kubudiswa kwehomoni endorphin, zvichiita kuti kuwedzerwa simba uye simba rinopesana nekuputika.
Izvo zvakafanana nezvinoitika panguva yekuzvimba apo yakawedzerwa endorphin mhizha inobatanidza nekuwedzerwa nguva dze MS remission.
Nepo kune imwezve inofanira kunge iine hutano hwakaoma hwechipatori inotsigira pfungwa, vamwe vanotsvakurudza vanodavira kuti LDN inogona kukwanisa kuderedza kusimba uye kuwandisa kwezviratidzo zveM MS zvakadai sokuneta, kurwadziwa, kupera , kuziva kusagadzikana , uye kuora mwoyo .
Mazano Okurapa
Kana yakatemwa mumatare maduku akadaro (pasi pe10 muzana yeiyo inoshandiswa mukurapa therapy), LDN inonzi yakachengeteka uye inobvumirwa zvakanaka.
Dhairiro inowanzotaurwa kune vanhu vane MS kubva kune 1.5 milligram kusvika ku 4.5 milligrams pazuva. Inorayirwa kuti vanhu vane chero nzira ipi zvayo yepasticity havatoreri mairigiramu matatu zuva rega rega sezvo zvingaita kuti musimba uomerwe.
LDN inogona kutorwa kana kuti isina kudya asi inofanira kutorwa pakati pe9: 00 masikati uye pakati peusiku kuti inyorerane kushanda kwomuviri wepanyama peak endorphin release.
Nyaya yakanyanya kufanana nayo yeLDD inoratidzirwa hope dzinowanzove dzichiderera shure kwevhiki yekutanga kana maviri. Pashoma zvishoma, kusagadzikana kwakave kuchizivikanwa kuti kunoitika.
Kufungisisa nekupikisa
Imwe yenharo huru mukushandisa DDN kusangana kwayo nemishonga yakawanda-inoshandiswa kurwara inoshandiswa kurapa MS. Kubva pamutemo we pharmacokinetic wemishonga, LDN haifaniri kushandiswa neAvonex , Rebif , kana Betaseron . Kusiyana neizvi, zvinoratidzika kunge pasina kukakavadzana neCopaxone .
Nemhaka yokuti yakanyanyisa kubva mumuviri kuburikidza nechiropa, LDN haina kukurudzirwa kune vanhu vane hepatitis, chirwere chechiropa, kana chirwere cheprhosis.
LDN haifaniri kuve yakabatanidzwa nemhando ipi neipi yeopiate-based iyo inosanganisira Oxycontin (oxycodone), Vicodin (hydrocodone). Kana kunyange codeine-based yakagunzva syrups.
Kudzokorora Uchapupu Hwezvino
Kunyange zvazvo kubvumirana kwakakurumbira kungaratidza kuti LDN inobatsira kuti hutano hwakanaka uye hupenyu huve nani hwevanhu vane MS, humwe uchapupu huripo hwave husanganiswa. Pakati pavo:
- Chidzidzo chekufambisa chiitiko chakaitwa paYunivhesiti yeCalifornia kuSan Francisco chaisanganisira vanhu 80 vane MS vakabatwa neLDN kwevhiki masere. Kunyange zvazvo LDN isina kuchinja basa remuviri kana kukwanisa kwevatori vechikamu, yakapa huwandu hwezvakawanda hunovandudzwa muhupenyu hwavo hwehupenyu (kusanganisira kuderedza marwadzo uye kuora mwoyo uyewo kuwedzerwa mukugadzirisa basa).
- Chiitiko cheChipiri II chakaitwa muItaly mugore ra2008 chakatarisa vanhu makumi mana nemasere ekutanga-shandura MS pamusoro peLDN mishonga kwemwedzi mitanhatu. Pakupedzisira, pakanga paine nhamba yekuvandudzwa kwepasticity (47 muzana yakavandudzwa, 11 muzana yakasuruvara) asi hapana kuvandudza pane kuora mwoyo (56 kubva muzana yakagadziriswa, 33 muzana yakawedzera) kana kuneta (33 muzana yakavandudzwa, 41 muzana yakawedzerwa). Kusiyana neizvi, LDN yakabatanidzwa nehuwandu hwekuwedzera kwekutambudzika (28 muzana yakagadziriswa, 56 muzana yakaipisisa).
- Mavhiki gumi nemazana makumi maviri nemasere akadzidziswa, akadzidziswa kudzidza muna 2010 haana kuwana nhamba yakasiyana pakati pevanhu vanotora LDN kana placebo kana chero humwe huri nani huri nani hwehupenyu hwehupenyu, hunosanganisira kurwadziwa, simba, kugona, uye mafungiro akanaka.
> Sources
> Cree, B ;; Kornyeyeva, E ;; naGoodin, D. "Chiremba chekuongorora chirwere chakashata naltrexone uye hupenyu hwehupenyu mune multiple sclerosis." Annals Neurol . 2010; 68 (2): 145-150.
> Gironi, M .; Martinelli-Boneschi, F .; Sacerdote, P. et al. "Mutyairi wechipurisa wepasi-dose naltrexone mu primary primary multiple multiple sclerosis." Mult Scler . 2008; 14 (8): 1076-83.
> Sharaaddinzadeh, N .; Moghtederi, A .; Kashipazha, D. et al. "Izvozvo zvinokonzera kuderedza-dose naltrexone pamusoro pehupenyu hwevarwere vane multiple sclerosis: chirongwa chisingatarisirwi chinonzi controlbo". Mult Scler. 2010; 16 (8): 964-9.