Irritable Bowel Syndrome uye Nervous System
Kusagadzikana muhutano pakati peuropi uye chirwere chinogona kunge chiri chinhu chinokonzera kushungurudza chirwere chendumbu (IBS).
Zvimwe zvinetso zveutano zvakanaka chaizvo kunzwisisa. Kana iwe uine chirwere chinorwadza , chiremba wako achatora samuu yechipfupa kubva pamutsipa wako otanga muedzo kuti aone kana une strep infection. Rimwe rinotarisa rinotarisa paganda rako rinogona kuongororwa kuti rione kana iri kenza.
Zvinosuruvarisa, IBS haisi kure nyore. Kusiyana nehutano hunoonekwa, kuti vanzwisise zviri kuitika mu IBS, vatsvakurudzi vakawana kuti vanoda kutarisa kunze kwemukati uye kumatanho akaoma ekukurukurirana anowanidza maronda kuuropi.
Kunyatsokoshesa basa iri kuitwa munharaunda ino, iwe unoda kuva nedhigiri muurourosi. Kunyangwe pasina chidimbu chakadaro, zvinobatsira kuva nekumwe kunzwisisa kwekukurukurirana kwakaoma pakati peuropi uye chirwere uye kuti izvi zvinorevei neBS.
Biology Basics
Ona kana imwe yenhaurirano inotevera ichinyora bhero kubva munguva yako yaunopedza muchikoro chesekondari yebhaibheri. Kukurukurirana pakati pezvikamu zvose zvemitumbi yedu kunoitika kuburikidza nokupfuura kwemashoko kubva kune nerve kusvika kune nerve. Heino tsanangudzo yakajeka yemigwagwa yakasiyana-siyana iyo inokurukurirana inoitika:
- Central nervous system (CNS): uropi nemutsipa wepelinha
- Peripheral nervous system (PNS): nerve nzira dzinowedzera kunze kwouropi uye musipinha.
Izvo purogiramu yenheyo yenyoka inowedzera kugoverwa muzvikamu zviviri:
- Somatic nervous system: inotarisira kuzvidira kuzvidzora kwemisungo uye kugadziriswa kune kunze kwekunzwa.
- Autonomic nervous system : inotarisira motokari uye mhinduro dzekunzwa kwemuviri wedu ( viscera ).
Enteric Nervous System
Izwi rinonzi enteric nervous system (ENS) chikamu chehurongwa hwehutongi hwezvigadziro hunoita kuti utonge chirongwa chekudya. I-ENS inotora motility (kufamba kwemisungo), kuchengetedza kwehutachiona uye kubuda kweropa. Iyo ENS inotarisira basa rakawanda rayo pachake kuti dzimwe nguva rinopiwa zita rokuti "uropi hudiki." Zvichibva kune tsanangudzo iyi, zviri nyore kuona kuti kunzwisisa kuti nzira ye enteric inoshanda inokosha sei kunzwisisa chii chingave chakaipa mu mutumbi une IBS.
Kumusoro kweSite Staircase
Kukurukurirana inzira mbiri pamugwagwa paunouya kuuropi (pakati penheyo system) uye chirwere chekudya (enteric nervous system). Nzira dzakakomba dzinobatanidza uropi uye hutumbu nemashoko anoyerera mberi uye mberi nguva dzose. Ukama hukama hwepedyo hunoonekwa zvakajeka mukupindura kwedu kudzvinyirira (kuonekwa kunotyisidzika), izvo zvinoratidza kuti iyi yakaoma yekukurukurirana mitambo yakakosha zvikuru kuti tipone semhuka.
Vanotsvakurudza vari kuwana uchapupu hwokuti kusabatsirana kune izvi zvichikwira uye zvichidzika nzira zvinogona kunge zvichiita kuti pave nemarwadzo emimba , kuvimbiswa uye / kana chirwere chiri zviratidzo zveBS. Mitsipa mumatambudziko ari kunetseka zvakanyanya kunogona kukonzera kuchinja muuropi.
Pfungwa, manzwiro, uye kushandiswa kwezvikamu zvehuropi zvine chokuita nekuzvidya mwoyo kana kumutsa zvinogona kukurudzira kugadzirisa mhinduro dzegadzi. Kushanda kunogona kuwanikwawo munzira dzakawanda dzakasiyana dzinobatanidza uropi uye mutumbi. Semuenzaniso, kune uchapupu hwokuti kushanda kusina kumira nenzira mbiri dzakasiyana-siyana muhurongwa hwehutongi hwehutongi hunobatanidza nechiratidzo chehurwere pamwe nechiratidzo chekuvharwa. Muzhinji, zvinoratidzika kuti kusagadzikana muhutano-mukati yekutaurirana chirongwa kunopesana nekukwanisa kwemuviri kuchengeta homeostasis, nyika umo maitiro ese ari kushanda zvakanaka.
Basa raSerotonin
Zvimwe biology: Nzira iyo imwe nhengo yesero inotaurirana nayo inotevera ndeyemakemikari anonzi neurotransmitters . Imwe yeurotransmitter inokosha zvikuru yekushanda kwemaitiro inonzi serotonin (5-HT). Inofungidzirwa kuti kusvika kusvika 95 muzana ye serotonin mumuviri womunhu inowanikwa munharaunda yekudya. Serotonin inoonekwa sechikamu chinokosha chekutaurirana kwehutano pakati pehupi nehutu. Serotonin inoratidzika kunge inobatanidzwa mune motility , kunzwisisika , uye kuchengetedzwa kwemvura. Movement, kurwadziwa kwekunzwa uye chiyero chemvura muhombodo - unogona kuona kuti sei serotonin yave iri kuongororwa kuvatsvakurudzi veBS.
Kusiyana kwakawanikwa mumasero e-serotonin pakati pevarwere vanotambura nehurwere kune avo vane kuvimbiswa. Varwere vane chirwere chepachirwere vaiva nepamusoro pemasero evanhu vese serotonin mushure mekudya, asi varwere avo vakatambura nekuvhara ropa vakanga vashoma kudarika serredonin. Iyi misiyano iri pasi pemaitiro ekuvandudza mishonga iyo inowedzera kana inowedzera masero e serotonin nekutsvaga zvimwe zvakagadziriswa nzvimbo ( 5-HT3 uye 5-HT4) kuzobata IBS. Kune mishonga miviri yakadaro, asi zvose zviri zviviri zvinorega zvirevo pamashandisirwo avo kuitira kudzivirira zvakakomba migumisiro yakaipa:
- Lotronex : 5-HT3 blocker yekurapa kwehara
- Zelnorm: L 5-HT4 inokurudzira kurapa kubatwa
Imwe itsva IBS yekutsvakurudza ruzivo inotarisa boka reproteins rinonzi serotonin reuptake transporters (SERTs). SERTs inotakura kubvisa serotonin mushure mokunge yabudiswa. Pane humwe hunoratidza kuti kune kusiyana kune basa reSERT apo IBS kana kuputika kuripo. Chimwe chikoro chekufunga ndechekuti kuwedzera kwe serotonin kunovhiringidza nzira ye homeostasis, nekudzivirira kuti chirwere chekudya chirege kushanda nenzira yakasununguka.
Zivo is Power
Unogona sei kushandura ruzivo rwako rutsva pakukubatsira kutarisa zviri nani IBS yako? Zviri pachena, iwe hauna simba rekukanganisa zvakananga mazinga ako serotonin. Zvisinei, kune nzvimbo mbiri apo zviito zvako zvine simba zvakananga pahutano hwekukurukurirana pakati pehupi nehutu.
Nokushandisa kusununguka maitiro , iwe unogona kushingaira kubvisa kupinduka kwepfungwa, umo mararamiro anoshanduka anouya mukupindura mhinduro nemanzwiro. Iwe unogonawo kufunga nezvegastrocolic reflex umo zvipfeko zvekoloni zvinokurudzirwa nokudya kudya kukuru kana kudya kwemafuta paunosarudza kuti ndezvipi zvokudya zvinodyiwa. Nokuda kwezuva, zvinenge zviri nani kudya zvokudya zvishomanana, panguva yekudzivirirwa, kudya kukuru kwaizove kwakanakisa kutanga kufamba kwechirwere.
Kunzwisisa kuti matambudziko ari muBS anowedzera nzira kunze kwekuve ne "chirwere chisina kunaka" inogona kukubatsira iwe kukudziridza nzira dzakasiyana-siyana dzekutarisana nematambudziko aya.
> Sources
> Fukudo S. Kushungurudzika uye kurwadziwa kwemaziso: Kuisa pfungwa pahasha dzinotyisa. Pain . 2013; 154. doi: 10.1016 / j.pain.2013.09.008.
> Meerveld BG-V, Johnson AC, Grundy D. Matumbo Physiology, uye Basa. Handbook of Experimental Pharmacology . 2017. ini: 10.1007 / 164_2016_118.
> Norton, W. & Drossman, D. "Symposium Summary Report" (2007) Chirwere cheMagestive Matters 16: 4 -7.
> Oświęcimska J, Szymlak A, Roczniak W, Girczys-Połedniok K, Kwiecień J. Zvitsva zvinowanikwa mumapathogenesis uye kurapwa kwechirwere chemafupa. Kufambira Mberi mune Zvirwere Sciences . 2017; 62 (1): 17-30. doi: 10.1016 / j.advms.2016.11.001.