Pain ye nhengo dzomukati uye IBS
Kana iwe uine hutachiona hwekudzivirira hupenzi, zvinoreva kuti iwe wakaderedza chidziro chekumwadziwa kwepamuviri uye kusagadzikana mukupindura kumanikidziro, kukurudzira, kana kusimuka mukati memimba. Maziso ekuona nezvekuona (visceral hyperalgesia) ndiro izwi rinoshandiswa kurondedzera ruzivo rwekutambudzika mukati memitezo yomukati (viscera) pane imwe nzira yakanyanya kupfuura yakasikwa.
Kuonekwa kwehutachiona hwehutachiona hunhu hunoratidzika hunoita hutsinye hwehuwel syndrome (IBS). Zvisinei, visceral hypersensitivity inogonawo kuvapo kune vanhu vane:
- Kwete-kurwadziwa kwepfupa kwepfungwa
- Functional dyspepsia
- Kunetseka kurwadziwa mumimba
Kuyera Viseca Hypersensitivity
Vatsvakurudzi vanodzidza kuonekwa kwechirwere ichi kuti vaedze kunzwisisa kuti sei vanhu vane IBS. Nokuda kwechinangwa chekutsvakurudza, visceral hypersensitivity inowanzoyerwa uchishandisa bhoon distension test. Izvi zvinoedza mhinduro yemurwere kumanikidzi mukati me rectum.
Mubharoon distension chirongwa, bhaluni mu rectum uye zvishoma nezvishoma izere nemhepo. Vanhu vanoratidzika sevari kuonekwa neve visceral hypersensitivity apo vanotaura marwadzo pamadanho ekudzvinyirira kudarika vamwe vanogona kumira zvakanyanya kukosha kwekuwedzera kwemhepo pasina kuudza kusagadzikana. Mukutsvakurudza kwakadaro, vanhu vane IBS vanowanzova nechirwere chepamusoro chinorwadza.
Visceral Hypersensitivity uye IBS
Kunyange zvazvo visceral hypersensitivity inoratidzika seyobatanidza neBB, chete inenge 30 muzana kusvika makumi mana kubva muzana yevanhu vane IBS vakawanikwa vakave nekunzwa kwekuwedzeredza kune distension mukati mekoni. Uye, zvinonakidza, hakusi kureva kuwirirana zvakananga pakati pekuwedzera kunzwisisika uye kuoma kwezviratidzo zveBS zvemunhu.
Zvinoratidzika kuti iyo visceral hypersensitivity inowanikwa kune vamwe vashandi veBS semusana pekuchinja kwehutano hwemagetsi huchiita kumativi ose ematumbo uye neuropi. Nzira dzenzira mumatumbo emimba dzinokurudzirwa kuti dzikurudzire, zvichiita kuti pave-reactivity uye inokonzera kurwadziwa kukura. Muvanhu vasina IBS, rectal distension inokonzera mhinduro mune zvikamu zvehuropi zvinosanganiswa nekugadzirisa marwadzo. Muchirwere cheBIBS, izvi zvinokonzera kukurudzira kunokonzera mhinduro muzvikamu zvehuropi zvine chokuita nekuchenjerera uye kuzvidya mwoyo-zvikamu zvehuropi zvinoshingedza kuwedzera kunzwa kwekunzwa.
Zvinokonzera Visceral Hypersensitivity
Pane imwe nguva visceral hypersensitivity yakagadzwa sechinhu chinokosha muBS, vatsvakurudzi vakashandura pfungwa dzavo kuti nei izvi zvingava senzira yekuvandudza zviri nani kuvhiringidza kweBS.
Kune dzidziso dzakasiyana-siyana shure kwechiitiko che visceral hypersensitivity muBS. Zvinhu zvakawanda zviri kuongororwa, kusanganisira:
- Marwadzo anobva kumitsipa yemasero akanyura mumatumbo makuru
- Kuchinja kune micro RNA molecule yemasero aya
- Kuchinja mune yeurotransmitter nezvimwe zvinogamuchirwa mukati memasero aya
- Kuchinja muhutano pakati penheyo yenheyo (brain and spinal cord) uye purogiramu yeropa yenzira (nzira kuenda uye kubva kune nhengo nemisumbu)
- Kuwedzerwa mumukaka kunokwana (leaky gut)
- Kuvhiringidzika (pamwero uri pasi apa izvo zvinogona kuonekwa kuburikidza nekuongororwa kuongororwa)
Kunzwisiswa zviri nani pamusoro pekuti masangano aya akaoma sei anobatanidza achabvumira kukura kwemishonga inotarisa nzvimbo dzisina kushanda uye inounza kuponeswa kubva kuzviratidzo zveBS.
> Sources:
> Akbar A, Walters J, Ghosh S. Visceral hypersensitivity mune zvinokanganisa maronda epfungwa: maitiro e molecular uyerapautic agents. Alimentary Pharmacology & Therapeutics 2009 30: 423-435.
> Zhou C, Verne N. Zvitsva zvinowanikwa mune visceral hypersensitivity - kliniki zvinoreva muBS. Nature Reviews Gastroenterology & Hepatology 2011 8: 349-355.