Vanhu Vakagadzirwa Nemaoko Masimba VHIV Kurwisa Kuedza Dummy Targets
Vatsvakurudzi vanobva kuHarvard Medical School uye Scripps Research Institute muFlorida vakazivisa kuti nhoroondo yegene gene, yakagadzirirwa intramuscularly, yakadzivisa kutapurirwa kweHIV-1 neHIV-2 mune rimwe boka re macaque mbongoro kakawanda rinoratidzirwa kurwere. Kuwanikwa kunoonekwa senhanho yekutanga yekuvandudza munhu anozvidzivirira muzvirwere anogona kukwanisa kudzivirira zvakafanana kuvanhu.
VaHarvard naVaScripps vatsvakurudzi vakakwanisa kuvaka ma molecule akaumbwa anonzi ECD4-Ig , iyo inofanidza mhando mbiri dzemapuroteni zvakagadziriswa zvinowanikwa pamusoro pemasero machena eAIDS anowanzobatanidza panguva yehutachiona. Mukuita kudaro, HIV ine "yakanyengedzwa" pakuzvichengeta pachayo paine maitiro ekugadzira, saka ichiipedza.
ECD4-Ig Works
eCD4-Ig yakaumbwa chidimbu cheCD4 uye chimwe chikamu cheCCR5 -ichocho chinogamuchirwa zvinogadzirisa zvinoita sekupinda "kuvhara" kune sero-iyo pamwe chete inosungirirwa pachikamu chechirwere . Iyo maitiro ekugadzira anobva aiswa mune adenovirus (rudzi rweutachiona husina hutachiona-hunokonzera zvirwere), hunoendeswa zvakananga mumashuga emasumbu. Kamwe apo, utachiona husina ngozi hunokurumidza kukonzera masero, kuisa DNA yacho mumusara, uye kuatendesa kuva mapuroteni mafukisi-kuwedzera huwandu hwehutachiona hunoshandiswa.
Mamwe mapepa ekushandisa "CD4-Ig" isingashandisi (kureva,, pasina chidimbu cheCCR5) yakangobatsira zvishoma.
Mune zvimwe zviitiko, kana kuwedzera kwezvirwere zvakashandurwa zvakanyanya kwazvo, basa reHIV rinongowedzera. Ichi ndechokuti HIV yakakwanisa kupukunyuka neutralization zvakakwana kuti iite mutende uye ikasungirire pane zvinyorwa.
Kunyange zvazvo HIV ichiri kukwanisa kupukunyuka uye kuchinja pamberi peECD4-Ig, iyo bivalent (kureva, inosanganisira maviri echromosomes) kubatana kunoratidzika kuisa mari inorema kune utachiona hutachiona, zvichiita kuti kuderedza kukwanisa kwayo kudzokorora.
Mune zvidzidzo zvezvipfuwo zvavanotungamirirwa, vatsvakurudzi vanotaura kuti mbongoro dzakaparadzaniswa neine genetically modified adenovirus dzakakwanisa kudzivisa matambudziko ose eHIV-1, HIV-2 uye SIV (iyo simi yehutachiona hweHIV), kunyange mushure mokunge uchinge uchinge uchinge uchinge uine huwandu hwakawanda hwe utachiona hwemavhiki makumi mana. Hapana imwe yemadhongi asina kuvhara yakatapukirwa, uye hapana inosangana neipi yakaipa kune eCD4-Ig (zvichida nokuti miviri yavo inoziva kuti mapuroteni seavo).
Mbongoro dzisina kupa eCD4-Ig inoculate dzose dzakapindwa.
Zvose Izvi Zvinorevei?
Kunyange zvazvo zvichiri kunyanya kutaurira kuti miedzo kuvanhu ichapa mhinduro imwe chete, nzira yacho inoratidza nzira inogona kuchinja-kutamba-mhanya mukugadzirwa kwechirwere chinopedza kubvisa HIV .
Vamwe vakatotanga kufungidzira kuti kukurudzirwa kwechirwere cheECD4-Ig chinobudirira, chinoshanda zvakanaka kubudirira kwenguva refu, chingava chakanaka mukuregeredza chirwere chetachiona mune varwere vane utachiona hweHIV, zvichida pachavo kana nevamwe vashandi. Kana izvi zviripo, chaizvoizvo, zvinobudirira, saka kunyange varwere vane zvakadzika, ma-multi-drug resistant vanogona kubatsirwa.
Kunyange zvakadaro, zvose izvi zvinoramba zvichiri kufungidzira. Kuwedzera kutsvakurudza kuchaita kuti zvive nemanzwisisiro akawanda mumwedzi inouya, zvichiratidza nzira yekutanga-miedzo yevanhu miedzo munguva inotevera.
Zvimwe Nhoroondo Inoenda kuGene Therapy
Mukuwedzera kune tsvakurudzo yeHarvard / Scripps, mumwe masayendisiti ari kutsvaga mune mamwe maitiro ekugadzirisa gadziriro kana kurwisa kana kudzivirira hutachiona hweHIV.
Imwe yakadaro mienzaniso kubva kuvasayendisiti paTech University yakatora zvikamu zveAIDS zvine utachiona hweHIV uye kubva muropa revarwere uye inoshandisa enzyme inonzi Cas9 kuti "snip" iyo HIV inoshandiswa kubva kune imwe DNA yemajeri. Nokuita kudaro, masero haakwanisi kutapukirwa neHIV.
Inotarisirwa kuti kuburikidza nekuvhara masero aya zvakare mumuviri wemurwere, kukwanisa kweHIV kubata kuchapera zvakanyanya, kunonoka kupfuurira kwezvirwere nekugonesa kuti masero zvakare akashandurwe ave chikamu chemuviri wemunhu (genetic makeup).
Saizvozvowo, masayendisiti kuUCLA ari kutsvaga kushandiswa kwemakemikari anogadzirwa anonzi CAR (chimeric antigen receptor), iyo inogona kuchinja sero rega rega muchitachiona chetsvuku chechiropa. Nokuisa CAR kuti ive ropa-kuumba masero emasero, masayendisiti akakwanisa kushandura masero mu "" mhondi "chaiyo" inoda kuregeredza kusununguka-kutenderera HIV.
Kunyange zvazvo zvidzidzo zvose zviri muchikwata chepamuviri chekuedza, izvo zvinoonekwa zvinonzi zvinokosha mukugadziriswa kwevanhu vanogona kuvhara HIV.
Sources:
Gardner, M ;; Kattenhorn, L .; Kondur, H .; et al. "AAV-inobudisa CD4-Ig inodzivirira zvakasimba kune dzakawanda SHIV Dambudziko." Nature. February 18, 2015; doi: 10.1038 / nature14264.
Kaminski, R; Chen, Y ;; Tedaldi, E .; et al. "Kuparadzaniswa kwema-genomes ane HIV-1 kubva kumunhu T-lymphoid cells ne CRISPR / Cas9 gene editing." Nature . March 4, 2016; rakabudiswa paIndaneti DOI: 10.1038 / srep22555.
Zhen, A .; Kamata, M .; Rezeki, V. et al. "Kusachengetedzwa Kwepabonde kweHIV Kwakatorwa Kubva kuChimeric Antigen Receptor-engineered Stem Cells." Molecular Therapy. August 2015; 23 (80): 1358-1367.