GP 120, GP 41, uye GP 160
HIV ndeyevhesi yakaputirwa. Izvo zvinoita kuti zvive zvakasiyana nemamwe akawanda ma- retroviruses . Iyo haina kungova neprotini jasi. Pane kudaro, apo HIV inobva pane imwe seni inotora inotora chikamu chema cell plasma membrane nayo. Izvozvo zvinyorwa zvinenge zvikava muhopepeti yeHIV. Kunyange zvakadaro, muhopepeyo yeHIV haisi kungoita chete yezvinhu zvinobva kumusha. Izvo zvakare inoumbwa nehutachiona hweHIV enveloppe.
Utachiona hweEVV envelopu hunoisa gp 41, gp 120, uye gp 160.
GP inomirira "glycoprotein". Glycoprotein ane carbohydrate, kana shuga, zvikamu pamwe neproteine backbone. Nhamba mushure megp inoreva urefu hweprotini.
Cherechedza: Haasi yose glycoprotein inobatanidzwa nemavirusi. Zvizhinji zvepuroteni zvakakosha zvikuru muzvirwere zvezvirwere zvezvirwere zvezvirwere zvinokonzerwa neglycoprotein. Saizvozvowo mamwe akawanda mapuroteni anowanikwa mumuviri womunhu.
Mapuroteni gp 120 zvichida ndiyo inozivikanwa zvikuru yehutachiona hweEVV. Mishonga yakawanda yeHIV yakaedza kuitsvaga. Izvo zvakakosha mukusunga kweHIV kune CD4 masero . Vatsvakurudzi vakawanda vanofunga kuti kana vakanyatsopindira gp 120 kusunga, vangagona kuderedza kutapurirwa kweHIV.
Mukuwedzera kune gp 120, gp 41 inokoshawo pakubatsira kupinda kweHIV mumasero anopinda. Iyo inobatsira membrane yevirusi uye sero membrane fuse. Ichi chikamu chinonyanya kukosha chekuita zvirwere. Iko kusanganiswa kwemasumbu maviri ndiyo danho rokutanga pakununura RNA yevirusi muchitokisi kudzokorora.
Ichokwadi kuti fusion inhibitor enfuvirtide inoshanda kuburikidza nekupindira gp 41. Gp 41 zvakare ipuroteni inochengetedza gp 120 inowanikwa kuvharopu yevirusi. Iyo inogara mu membrane uye inosunga kune gp 120. GP 120 haibatanidzi kumvupurupa zvakananga.
GP 160 haisi yechitatu yeprotepe inopirini.
Panzvimbo pacho, gp 160 ndiyo inomirira gp 120 uye gp 41. Puroteni yakakura inodhindwa neev envipe (gene) gene. Izvo zvino inoparadzaniswa muzvikamu zviviri zviduku nema enzyme mumusasa wemauto - 120 + 41 = 161. (GP 160 dzimwe nguva inotaurirwa kune imwe yega gp 120 uye gp 41. Zvisinei, izvo zvinotsausa.)
Basa rokutarisana neHIV Kupinda uye kushaya Infectivity
Utachiona hweEVV inoputika huine basa rinokosha mukupinda kweHIV uye kusagadzikana. Izvo zvinogona kunge zvakakosha mukudzivirira nekurapa. Zvisinei, zvinonakidza, nyaya ye HIV envelopu mapuroteni inowanzouya mukukurukurirana nezvekuongororwa kweHIV. Semuenzaniso, imwe yenyika yeWest Blot haina kufungidzirwa kuti ndiyo yakagadziriswa yeHIV kunze kwokuti munhu ane zvirwere zvinopesana nehutachiona hwe HIV nehutachiona hwepabonde.
Kunewo zvinetso zvekuti chirwere chekudzivirira HIV chingakanganisa sei zvirongwa zvekuedza. Nhamba inokura yevanhu vakabatanidzwa mumisungo iyi inogona kutungamirira kune dzimwe nhema dzakanaka dzeHIV antibody. Mishonga inowanzogadzirirwa kuita kuti muviri uite zvirwere zvinorwisana nemapuroteni chaiwo, akadai semapurojekiti ane HIV. Sezvo ma antibodies ari chaiwo asiri eRNA kuongororwa kweHIV, zvinogona kutungamirira kune nhema.
Ichi ndicho chimwe chinhu chiti kune mumwe munhu anogona kungova akanaka chete kana achibudisa zvirwere zvepisitini zvinogona kubatsira kudzivirira.
Kana iwe ukatora chikamu muhutachiona hweHIV, taurira chiremba wako. Iwe unofanirwawo kuchengetedza zvinyorwa zvine musoro zvekubata kwako. Zvinokwanisika kuti nzira dzose dzekuedza kuongororwa neHIV dzichazove dzisiri yakarurama kwauri.
Kunobva:
Cooper CJ, Metch B, Dragavon J, Coombs RW, Baden LR; NIAID HIV Vaccine Trials Network (HVTN) Chirwere-Inonzi Seropositivity (VISP) Task Force. Chirwere-chinokonzerwa nehutachiwana hweHIV / reactivity kune vaparidzi vasina kupindira vane HIV. JAMA. 2010 Jul 21; 304 (3): 275-83.