PMNs: Mhuri yeMachena Machechi
CHII CHINHU?
Polymorphonuclear leukocytes, kana PMNs, mhuri inokosha yemasero machena eropa. Mhuri yacho inosanganisira masero ezvirwere zvinonzi neutrophils, eosinophils uye basophils. Neutrophils, basophils uye eosinophils vose PMNs inogona kuwanikwa ichifamba mumaropa. Muchidimbu chemigumisiro yekuongororwa ropa, zvisinei, PMN inonyanyozivikanwa neyoti neutrophil.
Chii chinonzi P oly M orpho N uclear Zvinorevei?
Kunze kwe PMNs achitaura neboka rainzi ma cell, izwi racho rinorevawo maitiro avo. Peyumu + morph inoreva "maitiro akasiyana" uye nyukireya inoreva sero nuclei ye PMNs, kana yakasvibiswa uye ichionekwa pasi pekroscope. I-PMNs zvinozivikanwa nenzira yakasiyana-siyana isinganzwisisiki yemhando iyo nuclei yavo inogona kutora. Nuclei yeMDCN yeropa dema rega ine zvikamu zvakadzama zvakasarura kuitira kuti panzvimbo yekutarisa sekanaka, denderedzwa kumativi ose muchikamu chemuchinjikwa, vangaita sevari vaviri kana matatu. Izvi zvinokonzera kuti "mazai echando" aonekwe, akaenzana nemamwe masero evanhu, kuti ave pachena kuti asipo-pane kudaro, sero rinoratidzika sezai raive rakaputika rakagadzirwa panguva yekubika.
Ndivana PMNs Granulocytes?
Ehe. Mukuwedzera kune inonakidza nuclei, PMNs inewo granules iyo inogona kuonekwa kushandiswa mavara neatini; iyo granules yakafanana nemabhaluni emvura maduku mukati memusero, uye inopa PMNs maitiro avo.
Nokuda kwechikonzero ichi, PMNs inowanzonzi "granular leukocytes" kana granulocytes. Icho chiri mukati memagranules chinoenderana nemamwe maMPN aunotaura nezvazvo. Mune mhosho ye-neutrophils, iyo granules ine enzymes nezvinhu zvine maitiro antimicrobial ayo, kana akasunungurwa, anobatsira kurwisa utachiona.
Ndeipi PMNs Inobva kupi?
PMNs pamwe nemamwe marudzi emasero machena eropa, masero matsvuku eropa, uye maplatelets ose anoburuka kana kuwedzera kubva pa hematopoietic stem masero mumupfupa. Kubva pane hematopoietic stem masero, masero eropa anosiyanisa munzira mbiri mbiri, dzakasiyana-siyana: lymphoid cell line iyo inoramba iine lymphocytes, uye myeloid cell line , iyo inokonzera mhando dzakasiyana dzeMDCN, pamwe nemamwe masero eropa.
Ndeapi Ari Kuwanikwa?
PMNs masero eropa machena anogona kuwanikwa muropa. Zvisinei, masero machena anowanzokwanisa kutevera zviratidzo zvemakemikari, kuenda kune zvakasiyana-siyana mumutumbi uko paanenge achidikanwa, unogonawo kuwana PNN mune dzimwe nzvimbo, zvakadai pane zvikamu zvehutachiona kana kuputika.
Zvose zvinoshanda Pamwe Nenzira Iyoyo?
Kwete, mumwe wega akasiyana nemasero machena eropa ane maitiro akasiyana-siyana muhutano nehutano, uye anogona kuve akabatanidzwa mune zvakasiyana-siyana mukati mehutachiona hwehutachiona, kunyange kune zvimwe zvinobatana. Kufanana nemasero ese eropa, PMN imwechete iyo inogona kubatsira mukudzivirira uye pakurwisana nehutachiona, mune dzimwe mamiriro ezvinhu, inobatsira mune zvingangove zvinokuvadza kana kuti zvisina kuenzana mhinduro, zvakadai semishonga yepamusoro uye mhinduro dzakakura dzese.
VANOITEI?
Apo zvinouya kune vanorwara nekenza, neutrophils ndiyo PMN inonyanya kukosha mukurwisa utachiona. Zvechokwadi, ivo ndivo vakakosha zvikuru-kurwisa WBC, nguva, maererano neAmerican Cancer Society. Kuti uwane pfungwa yakanaka yehuwandu hweweetrophil, vanachiremba vanoshandisa chiyero chinonzi absolute neutrophil count, kana ANC. Munhu ane hutano ane ANC pakati pe 2,500 ne6 000.
Mabasa eeutrophils nemamwe PMNs anotsanangurwa pasi apa:
- Neutrophils - Neutrophils ndiyo nzira yekutanga yekuzvidzivirira kumabhakitiriya, mavairusi, uye zvirwere zvehutachiona, uye ndivo vekutanga kuonekwa panzvimbo. Apo pane kuora kwepanyama, zvinhu zvinonzi chemotactic zvinhu zvinosunungurwa zvinokwevera neutrophils.
- Eosinophils - Eosinophils inoshandiswa mune zvinokonzerwa nemararamiro uye kunewo zvirwere zvakashata zvakadai sehonye. Izvo zvikamu zvepamusoro eosinophils muropa zvinogona kubva kune mamwe mamiriro ezvinhu, zvakare, zvakadai sekushandiswa kwemishonga.
- Basophils - Basophils inobatanidzwawo mune zvinokonzera , uye inoparidzira histamine nedzimwe mishonga dzinokonzerwa nekuputika uye kudzivirira ropa kubva pakuvhara. Basophils inopa ropa rinokwana mast cells, izvo zvizere zvakasungwa-zvisungo (basophils zviri muropa; mamasi masero ari mumatumbu).
Mast Maselo muTissues:
- Mast cells - Mumiviri, masasa mashese anoita basa rinokosha mukupema uye kushaya muviri . Mast masero anowanikwa mune 2 mazana subtypes: maitiro anobatana uye mucosal. Vose subtypes vanogona kusunungura preformed granules. Mucosal nzvimbo dzakabatana, zvakadai sedanda remukati, kana chigadziko chemhepo. Nhengo dzakagadzikana dziripo zvakadzika kudarika idzi linings uye mune dzimwe dzimba, zvakare. Muzvikamu zvose zviri zviviri, masiti mashoma anogona kushandiswa uye kubvumira, kana kusiya mubhadharo wavo wegranules. Zvinhu zviri mukati mazvigunwe zvadzo zvinoshanda semasero emagetsi uye zvinoshanda musangano nemamwe masero ezvirwere.
Zvimwe pane PMNs uye Immunity
PMNs chikamu chesingazivikanwi inonzi immate system system. Izvi zvinorevei kuti vanobata vese vanoita nenzira yakafanana. Izwi rinonzi innate rinoreva kuti urongwa huno huripo kubva pakuberekwa - masero haafaniri kudzidza kudzidza avo vanovhiringidza. Vanovaziva kubva pakuenda-kuenda.
Izvi zvinopesana nemasikirwo emunoda akawanikwa. Mune maune immune system yakawanikwa, masero ezvirwere zvemuviri anokwanisa kudzidza kuziva muvengi uye anopisa mhinduro dzekuzvidzivirira mumuviri. Mhinduro yacho inowanzooma uye yakawanda, inosanganisira masero ezvirwere anozivikanwa seB uye T lymphocytes, pamwe nemasero anogadzirwa an antigen, kana APCs, anonyanya kujekesa lymphocytes sekuonekwa kwekune dzimwe nyika antigen.
Mamiriro ezvinhu anosanganisira Mazinga Asina Kunaka eMDCN
- Musoro mazinga eetrophils muropa anowanzokonzerwa nehutachiona, sezvo aya masero anoshevedzwa kuti adzivirire muviri.
- Kana muviri usingakwanisi neutrophils yakakwana, izvi zvinogona kuwirirana nemukana wemunhu wekudzivirira utachiona. Mimwe mishonga yekenza inogona kukonzera maitiro eutrophil kuwira, zvichiita mune izvo zvinozivikanwa seveutroenia. Muchikwereti chemotherapy-induced neutropenia, vachengeti vehutano vanochengetedza pangozi yehutachiwana nenzira dzakasiyana-siyana.
- Kuwedzerwa kwezvinyorwa zvinonzi eosinophils zvinonzi eosinophilia , uye zvinowanzonzerwa nekugadzikana kwemaitiro, kushandiswa kwezvinodhaka, kana kutapurirana nemaronda, uye zvishoma nezvishoma nekenza nemamwe mamiriro. Kushayikwa kwemasero aya hakuwanzoitiki.
- Kuwedzerwa kwebasophils kunogona kuitika ne hypothyroidism uye nedzimwe zvirwere zvekenza. Zvimwe zvinetso zvakabatanidzwa nehuwandu hweasophil mazinga zvinosanganisira Crohn chirwere uye ulcerative colitis-iyo yose inonzi inoputira chirwere chechirwere.
Sources:
Kurashima Y, Kiyono H. Nguva itsva ye mucosal mast cells: mabasa avo mukuputika, zvirwere zvezvirwere zvezvirwere uye kugadzira adjuvant. Experimental & Molecular Medicine (2014) 46, e83.
Canadian Cancer Society. Anatomy uye physiology yeropa. Yakasvika 02/24/16. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/anatomy-and-physiology/?region=on
Williams, L. "Kuongorora kwakakwana kweHematopoiesis uye Immunology: Zvinokonzerwa neHematopoietic Stem Cell Transplant Acceptors" muEzzone, S. (2004) Hematopoietic Stem Cell Transplantation: Bhuku Rekuchengetedza Maitiro Oncology Inobatsira Vamukoti: Pittsburgh, PA (pp.1- 12)